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41.
Global change, i.e. the mega-process radically transforming the relationship between nature and human civilization since
the end of World War II, is investigated from the point of view of systems analysis. It is argued that this unbridled process
should rather be domesticated by planetary control strategies transpiring from a new science called “geocybernetics”. The
formal aspects of geocybernetic theory are sketched and illustrated in a tutorial theatre world reflecting the overall environment
and development problematic. Within this setting a straightforward operationalization of the sweeping “sustainable development”
ideal through a set of concise paradigms can be achieved. Evidence is provided that geocybernetics is actually feasible on
the basis of earth system modelling and fuzzy-control techniques. 相似文献
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H. T. Schreuder 《Environmental monitoring and assessment》1994,33(3):237-245
Simplicity and efficiency in design and estimation are all important in deciding on sampling strategies. A simple model is given and illustrated for four practical situations to show how a good sampling strategy should be selected.The U.S. Government right to retain a non-exclusive, royalty free licence in and to any copyright is acknowledged. 相似文献
44.
This study examines 45 cases of trisomy 13 and 59 cases of trisomy 18 and reports an algorithm to identify pregnancies with a fetus affected by trisomy 13 or 18 by a combination of maternal age fetal nuchal translucency (NT) thickness, and maternal serum free β-hCG and PAPP-A at 11–14 weeks of gestation. In this mixed trisomy group the median MoM NT was increased at 2.819, whilst the median MoMs for free β-hCG and PAPP-A were reduced at 0.375 and 0.201 respectively. We predict that with the use of the combined trisomy 13 and 18 algorithm and a risk cut-off of 1 in 150 will for a 0.3% false positive rate allow 95% of these chromosomal defects to be identified at 11–14 weeks. Such algorithms will enhance existing first trimester screening algorithms for trisomy 21. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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47.
A. Coulomb L'Herminé A. Aboura S. Brisset L. Cuisset V. Castaigne P. Labrune R. Frydman Dr G. Tachdjian 《黑龙江环境通报》2003,23(11):938-943
Prader–Willi syndrome (PWS) results from either paternal deletion of 15q11–q13, or maternal uniparental disomy (UPD) of chromosome 15 or imprinting center mutation. Prenatal diagnosis of PWS is currently indicated for chromosomal parental translocation involving chromosome 15 and for decreased fetal movements during the third trimester of gestation. Here we present the prenatal diagnosis of PWS during the first trimester of gestation and autopsy findings. Chorionic villus sampling (CVS) was performed for advanced maternal age at 13 weeks' gestation. CVS showed mosaicism including cells with a normal karyotype and cells with trisomy 15. Amniocentesis showed cells with a normal karyotype. Molecular analysis demonstrated that the fetus had a typical PWS abnormal methylation profile and maternal disomy for chromosome 15. Fetal ultrasound examination showed slightly enlarged lateral ventricles and hypoplasic male external genitalia without intra-uterine growth retardation. The autopsy showed a eutrophic male fetus with facial dysmorphy, hypoplasic genitalia, abnormal position of both feet and posterior hypoplasia of the corpus callosum. This report points out that in a karyotypically normal fetus with ambiguous male external genitalia and cerebral anomalies, extensive cytogenetic and molecular biology studies are strongly recommended because of risk of PWS. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
48.
Mamoru Morikawa Kazutoshi Cho Soromon Kataoka Emi H. Kato Takashi Yamada Hideto Yamada Hisanori Minakami 《黑龙江环境通报》2005,25(3):250-252
Two cases with a large cystic mass within the placenta are reported. By ultrasonography, it was found that both women had a subchorionic hypoechoic lesion (11.0 × 4.8 × 4.0 cm and 6.6 × 3.7 × 2.2 cm, respectively) at 24 and 35 weeks of gestation, respectively. In both cases, turbulent blood flow generated by a pulsatile jet flow (pulse rate; 40 to 60 beats per minute) into the cystic lesion seen on real-time imaging and lesions being low intensity on T1-weighted and isointensity on T2-weighted magnetic resonance image suggested that they contained fresh maternal blood. In both cases, the sonolucency of the lesions did not change until cesarean deliveries of females, both of whom were small-for-gestational-age infants (1940 g at 37 weeks and 2195 g at 37 weeks, respectively). Biochemical analysis of the fluid in the cystic lesion sampled during the cesarean section in the latter case confirmed that the fluid had originated from the maternal blood. These lesions histologically corresponded to large avillous areas surrounded by normal villi. Thus, a huge placental lake was diagnosed in both cases. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
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50.
Stéphanie Couvreur-Lionnais Thierry Rousseau Nicole Laurent Christel Thauvin-Robinet Eve Senet-Lacombe Anne Lise Delezoïde Francine Mugneret Christine Durand Laurence Faivre Paul Sagot 《黑龙江环境通报》2005,25(2):172-175
Juberg–Hayward syndrome is a rare autosomal recessive syndrome characterised by the association of growth retardation, microcephaly, cleft lip and palate, and thumb and radial ray abnormalities. To date, no prenatal cases have been reported. Here, we report on the first prenatal case of Juberg–Hayward syndrome. The diagnosis was established following fetopathological study. Besides the cardinal features of the syndrome, this prenatal case was remarkable for the severity of the short arm malformation and by the finding of big toe agenesis and cerebral abnormalities including hydrocephalus, agenesis of corpus callosum, and cerebellar hypoplasia. We conclude that the diagnosis of Juberg–Hayward syndrome can be discussed prenatally following ultrasound diagnosis of the association of intrauterine growth restriction, microcephaly, thumb/radial anomalies, and cleft lip/palate. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献