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Theresa Reischer Sandra Liebmann-Reindl Dieter Bettelheim Sukirthini Balendran-Braun Berthold Streubel 《黑龙江环境通报》2020,40(12):1532-1539
Objective
In this retrospective study, we describe the clinical course, ultrasound findings and genetic investigations of fetuses affected by fetal akinesia.Materials and Methods
We enrolled 22 eukaryotic fetuses of 18 families, diagnosed with fetal akinesia between 2008 and 2016 at the Department of Obstetrics and Feto-Maternal Medicine at the Medical University of Vienna. Routine genetic evaluation included karyotyping and chromosomal microarray analysis. Retrospectively, exome sequencing was performed in the index case of 11 families, if stored DNA was available. Confirmation analyses and genetic diagnosis of siblings were performed by using Sanger sequencing.Results
Whole exome sequencing identified pathogenic variants of CNTN1, RYR1, NEB, GLDN, HRAS and TNNT3 in six cases of 11 families. In three of these families, the variants were confirmed in the respective sibling.Conclusions
The present study demonstrates a high diagnostic yield of exome sequencing in fetuses affected by akinesia syndrome, especially if family history is positive. Still, in a large part the underlying genetic cause remained unknown, whereas precise clinical evaluation in combination with exome sequencing shows to be the best tool to find the disease causing variants. 相似文献146.
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Dr Ingo Kennerknecht Sabine Krämer Dieter Grab Rainer Terinde Walther Vogel 《黑龙江环境通报》1993,13(4):257-269
Data in the literature suggest that confined placental mosaicism might be associated with intrauterine growth retardation. However, this association may be coincidental and due to bias of ascertainment. We therefore started a prospective study based on the cytogenetic evaluation of placentae derived from growth-retarded newborns. We further minimized possible bias by excluding those small-for-date infants displaying findings which already could explain intrauterine growth retardation (mothers who are smokers, multiple pregnancies, gestosis, dysmorphic infants). In a collection of 71 small-for-gestational age newborns, we did not see a single case of true confined placental mosaicism. 相似文献
148.
Elisabeth Brandes Maria Mitu Dieter Pawel 《Journal of Loss Prevention in the Process Industries》2007,20(4-6):536-540
It is well known that explosive mixtures can exist at temperatures below the flash point (FP). Experiments show that the difference between the FP and the lower explosion point (LEP) may be up to 15 K and in some special cases even more. Consequently, an industrial process even running a few Kelvin below the FP may operate in an explosive vapour/air-atmosphere. Operating at temperatures below the LEP gives sufficient safety. Calculated LEPs are discussed and compared with experimental results. 相似文献
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