Effect of hydrogen sulfide in comparison to atorvastatin on endothelial damage in cholesterol-fed rabbits

Hydrogen sulfide (H₂S) is an endogenous gaseous molecule, functioning as a physiological regulator. This study aimed to investigate the role of H₂S in atherosclerosis. Rabbits receiving high cholesterol were given atorvastatin (10 mg/kg/day, orally) or sodium sulfide (1.1 mg/kg/day, intramuscular) 2 weeks after commencement of high-cholesterol diet and continued for 4 weeks. Serum lipid profiles, lipid peroxidation indexed as malondialdehyde, glutathione, superoxide dismutase, the vascular adhesion molecule-1, and aortic vascular endothelial growth factor were determined. Rabbits receiving a high-cholesterol diet showed elevated levels of total serum cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde and vascular adhesion molecule-1, and aortic vascular endothelial growth factor expression and lower levels of high-density lipoprotein cholesterol, glutathione, and superoxide dismutase. Treatment with atorvastatin and sodium sulfide has beneficial effects on serum lipid profile, oxidative damage, vascular adhesion molecule-1, and aortic expression of vascular endothelial growth factor.     

The Ergonomic Program Implementation Continuum (EPIC): Integration of health and safety - A process evaluation in the healthcare sector

IntroductionThis article presents a health and safety intervention model and the use of process evaluation to assess a participatory ergonomic intervention.MethodThe effectiveness of the Ergonomic Program Implementation Continuum (EPIC) was assessed at six healthcare pilot sites in Ontario, Canada. The model provided a framework to demonstrate evaluation findings.ResultsParticipants reported that EPIC was thorough and identified improvements related to its use. Participants believed the program contributed to advancing an organizational culture of safety (COS). Main barriers to program uptake included resistance to change and need for adequate funding and resources. The dedication of organizational leaders and consultant coaches was identified as essential to the program's success.Impact on IndustryIn terms of impact on industry, findings contribute to the evidence-based knowledge of health and safety interventions and support use of the framework for creating a robust infrastructure to advance organizational COS and link staff safety and wellness with patient safety in healthcare.     

Transformation of copper oxide and copper oxide nanoparticles in the soil and their accumulation by Hordeum sativum

Environmental Geochemistry and Health - In recent years, the study of the influence of nanoparticles (NPs) on the environment has attracted much interest as nanotechnology is becoming the key...     

离子迁移谱检测化学战剂的研究进展

环境及生物样品中化学战剂的分析检测一直是禁化武领域的研究热点.离子迁移谱因具有分析快速、灵敏、可小型化等优点,成为现场快速检测化学战剂的有效手段.本文首先说明了离子迁移谱的基本原理和设备结构,阐述了非放射性离子化源的发展对检测对象广谱化的影响,介绍了离子迁移谱与热解吸、闭管采样、固相微萃取、吸气式冷凝器等前处理装置的结...     

Application of XAFS and XRD methods for describing the copper and zinc adsorption characteristics in hydromorphic soils

Environmental Geochemistry and Health - Modeling metal sorption in soils is of great importance to predict the fate of heavy metals and to assess the actual risk driven from pollution. The present...     

Assessing the impact of converting roundabouts to traffic signals on vehicle emissions along an urban arterial corridor in Qatar

The type of control at intersections has a major effect on the operation of any urban corridor. Different predefined procedures are available to calculate some of the main operational characteristics, such as capacity, delay, and level of service, in order to select the best type of control. However, there are other important factors that affect major arterials operational characteristics, factors that are not fully addressed, such as the impact of emissions. In this study, a microscopic simulation approach using VISSIM and MOVES was developed to assess the environmental effect of converting four three-lane roundabouts to signalized intersections along a heavily congested urban corridor in Qatar. A decision was made to switch all roundabouts to traffic signals for better operations. Preliminary results indicated that the signal control outperformed the roundabout in the range of 37% to 43% reduction in emissions. A more detailed analysis revealed that roundabout corridor operations’ effects on emission rates are divergent from those of signalized corridors, particularly upstream and downstream of the intersections. Immediate roundabout upstream approaches are driver behavior dependent, characterized by substantial coasting at lower speeds and subsequent re-accelerating with less idling, described as acceleration events, which resulted in high emission rates, while signalized corridors are signal timing dependent, characterized by ample idling with less coasting and re-acceleration, resulting in reduced emission rates. The results also revealed that there was no significant difference between emission rates in the vicinity of the two types of control. Both recorded nearly the same emission rate.

Implications: A microscopic simulation approach using VISSIM and MOVES was developed to assess the environmental effect of converting four three-lane roundabouts to signalized intersections along a heavily congested urban corridor in Doha, Qatar. Intersection geometries along with the control type have significant impact on emission rates and play a major role in assessing environmental impacts. US EPA MOVES was calibrated to Qatar conditions which can be used to estimate emission factors and quantify vehicular emissions along other corridors in the country. The results can also be beneficial for other countries within the region.     

Bioindication of soil pollution in the delta of the Don River and the coast of the Taganrog Bay with heavy metals based on anatomical,morphological and biogeochemical studies of macrophyte (Typha australis Schum. & Thonn)

Environmental Geochemistry and Health - The results of biogeochemical and bioindication studies on the resistance of natural populations of macrophyte plant—cattail (Typha australis Schum....     

Economic and financial aspects of mine closure

Today, mine reclamation is a key component to a successful mine plan. Most of the industrialized nations have recognized the need to make mining activities relatively environmentally friendly, if they want to continue to benefit from the economic gains from mineral resource development. Countries such as the United States, Canada, Australia and South Africa are leaders in the field and have implemented relatively sophisticated legislation to ensure environmentally correct mine closure. These countries rely on a combination of strict control strategies and economic penalties to ensure compliance. Yet, from the firm's perspective, reclamation activities are counterproductive as they cut into profits. In order to attract economic development and earn much needed economic capital, most of the rest of the world, particularly the developing countries, lack effective mine closure legislation. The traditional command and control type of legislation that is sometimes used is either vague and therefore avoided, or not enforced appropriately, resulting in an undesirable level of environmental degradation. With the use of case studies from Brazil, this article shows that direct controls are effective in some instances and not in others. It proposes that economic and financial tools may be more effective than the traditional direct controls in getting firms to comply with environmental standards, particularly in developing countries where environmental compliance is more difficult to achieve. It explains the use of performance bonding as one type of economic incentive that has proven to be an effective environmental policy in mine planning and closure. The authors additionally push beyond the typical style of performance bonds to introduce a flexible bonding and insurance system that allows governments to maintain strict environmental standards but limits firms financial exposure during the mining process. Such a system learns from the successes of the industrialized countries that use performance bonding and is sensitive to the needs of developing nations to attract investment yet maintain environmental integrity.