Objective: Older drivers are somewhat more likely to be involved in car crashes than middle-aged drivers but less likely to be involved than younger drivers. This study aimed to assess the extent of drug use in older suspected drunk and drugged drivers, with respect to which drugs were detected and at which concentrations.
Methods: Blood samples from older suspected drunk and drugged drivers taken between February 1, 2012, and May 22, 2013, were identified from the database at the Norwegian Institute of Public Health and were retrospectively analyzed for a broad repertoire of drugs relevant for impairment. The prevalence of different drugs among the suspected drunk and drugged drivers was studied. Regarding drug concentrations, the findings in older drivers (>65 years) were compared to a reference group of apprehended drivers aged 20–40 years.
Results: Four hundred and ten older suspected drunk and drugged drivers were included. Any drug (including ethanol) was detected in 92% of blood samples, and ethanol was detected in 81%. Benzodiazepines were found in 15% of the older drivers and z-hypnotics (zopiclone or zolpidem) were detected in 13%. The most frequent single legal drugs found in blood samples taken from older impaired drivers were zopiclone (9.8%) and diazepam (9.3%). Regarding drug combinations, older drivers used a mean number of 1.4 drugs, and 20% of ethanol-positive cases showed at least one other drug. High drug concentrations of clonazepam and diazepam were more frequently seen in the younger group.
Conclusions: This study showed that drugs were detected in the vast majority of older drivers suspected for drunk or drugged driving. Ethanol was the most frequent drug detected, followed by zopiclone and diazepam. Older drivers combine drugs to a lesser degree than younger drivers, but their combination of ethanol and other drugs represents a considerable traffic risk. Lower concentrations of benzodiazepines are seen in older compared to younger drivers. 相似文献
A field method is described, which allows the qualitative estimation of pesticide contamination in the edgeof-field runoff. The method employs cheap and easy-to-use runoff sampling bottles, which were installed in an agricultural stream catchment over a period of three growing seasons. During this time 18 runoff events were detected, in nine of which insecticide contamination was measured (maximum concentrations: lindane 0.7 μg l−1 and 12.7 μg kg−1, parathion 20 μg l−1 and 728 μg kg−, fenvalerate 18.4 μg 1-1 and 924 μg kg−1). These insecticides were detected mainly as particle-bound chemicals. On about 80 % of the occasions the presence or absence of runoff measured in the field was in agreement with a simulation of runoff presence or absence using the runoff model KINEROS. 相似文献
Summary. The capacity of benzoxazolinone metabolization of dicotyledonous species characteristic for the former vegetation classes
Secalietea (grain field weed communities) and Chenopodietea (hoed vegetable communities) was estimated by the production of
BOA-6-OH, BOA-6-β-O-glucoside, and BOA-N-glucoside. Except for Urtica urens, Galinsoga ciliata, and Polygonum aviculare (Chenopodietea), all species tested were able to synthesize BOA-6-OH, its glucoside, and BOA-N-glucoside, but effectiveness
of BOA metabolism differed highly depending on species and plant organ. There was no correlation between bacterial phenoxazinone
production and appearance of metabolites in the plants. Bioassays demonstrated that N-glucosylation is more efficient in BOA
detoxification than O-glucosylation. The intermediate BOA-6-OH, however, is more harmful than BOA itself. It is therefore
assumed that the ability to synthesize BOA-N-glucoside reduces the sensitivity to BOA strikingly. Since the detoxification
capacity did not correlate with the taxonomic position, the affiliation of the species tested with the corresponding plant
communities was taken into consideration. Evidently, the ecobiochemical potential of species to detoxify benzoxazolinone,
regarded as an essential secondary compound in rye and wheat fields, reflects their occurrence in those plant associations.
The ability to cope with the compound could be the result of co-evolutionary processes and presents a hidden aspect of allelopathic
interaction.
Received 4 January 1999; accepted 14 June 1999. 相似文献
Since 2007, the ecosystem of the Gulf of Lions has shifted to a different regime, characterised by a low anchovy (Engraulis encrasicolus) and sardine (Sardina pilchardus) biomass and a remarkably high sprat (Sprattus sprattus) biomass. Surprisingly, the abundance and recruitment of anchovy and sardine remained high. To understand which processes (bottom-up or top-down control, etc.) could have caused this shift, we studied the changes in body condition, growth and size and age of anchovy, sardine and sprat over 1984–1985 and 1992–2012, using data from scientific surveys. The annual age structure of anchovy and sardine was estimated using Bayesian mixture models based on size frequency data with priors on the age–length relationship derived from independent otolith readings. The results indicated periods during which anchovy and sardine were in an average (1992–2004), good (2005–2007) or poor (2008–2012) overall state of condition. For sardine, the shift towards smaller fish observed during these past 4 years was explained by a combination of slower growth and the disappearance of older individuals (ages 2+). Despite the increase in biomass of sprat since 2008, indications were found that sprat was also smaller than in the past. As growth and condition decreased and overexploitation has not been documented or suspected for those three species in this area, we propose that the current decline in sardine and anchovy biomass could be due to qualitative and/or quantitative modifications in the planktonic production (i.e. a bottom-up control) or mass mortalities of adults due to an epidemic disease. 相似文献
Song is used as a signal in sexual selection in a wide range of taxa. In birds, males of many species continue to sing after pair formation. It has been suggested that a high song output after pair formation might serve to attract extra-pair females and to minimise their own partner’s interest in extra-pair copulations. A non-exclusive alternative function that has received only scant attention is that the amount of song might stimulate the own female’s investment into eggs in a quantitative way. We address these hypotheses in a captive population of zebra finches, Taeniopygia guttata, by relating male undirected song output (i.e. non-courtship song) to male egg siring success and female reproductive investment in two different set-ups. When allowed to breed in aviaries, males with the highest song output were no more attractive than others to females in an analysis of 4,294 extra-pair courtships involving 164 different males, and they also did not sire more offspring (both trends were against the expectation). When breeding in cages with two different partners subsequently, females produced larger eggs with more orange yolks when paired to a male with a high song output. These findings suggest that singing activity in paired zebra finch males might primarily function to stimulate the partner and not to attract extra-pair females. 相似文献
Next to predator detection, primate vigilance also serves to keep track of relevant conspecifics. The degree of vigilance towards group members often reflects the dominance rank of an individual: subordinates pay attention to dominants. Although it has been suggested that subordinates' vigilance may result in spatial centrality of dominants, this has not been addressed in either empirical or modeling studies. Using agent-based models, we determined how social vigilance affects socio-spatial properties of primate groups. A basic model without social vigilance, where individuals avoid potential aggressors (avoidance model), was contrasted with two models that each additionally included a different type of social vigilance: a) monitoring a specific potential aggressor to remain informed on its whereabouts (monitoring model) or b) scanning the whole group to detect potential aggressors (scanning model). Adding monitoring or scanning behavior to the avoidance model reinforced spatial centrality of dominants, a pattern often observed in primates, and resulted in more spread out groups. Moreover, variation in scanning tendency alone was already sufficient to generate spatial centrality of dominants: frequently scanning subordinates could move further away from the group center than dominants, before losing sight of group members. In the monitoring model, two mechanisms caused decreased encounter frequencies among subordinates: a) increased inter-individual distances, and b) frequent monitoring of central dominants. In the scanning model, encounters among subordinates decreased due to increased inter-individual distances. This agent-based model study provides a clear indication that individual variation in social vigilance may be an important structuring feature of primate social groups. 相似文献