Effect of TRF1 rs3863242 polymorphism on telomere length in omethoate-exposed workers

Abstract

Telomere length was found to be associated with omethoate exposure and polymorphisms in certain genes among occupational workers. However, whether the polymorphisms in telomere-binding protein genes influence telomere length remains unclear. To explore the correlation between telomere length and polymorphisms in telomere-binding protein genes, telomere length in peripheral blood leukocytes was determined by real-time quantitative polymerase chain reaction in 180 omethoate-exposed workers and 115 healthy controls. Polymorphisms in 10 pairs of alleles were detected using flight mass spectrometry or polymerase chain reaction–restriction fragment length polymorphism technique. The results showed that individuals with GG genotype in TRF1 rs3863242 had longer telomere lengths than those with AG?+?AA genotype in the control group (p?=?0.005). The multiple regression analysis suggested that both omethoate exposure (b?=?0.526, p?<?0.001) and TRF1 rs3863242 GG (b?=?0.220, p?=?0.002) were related to a longer telomere length. In conclusion, GG genotype in TRF1 rs3863242 is linked to prolongation of telomere length, and individuals with GG genotype are recommended to strengthen health protection in a Chinese occupational omethoate-exposed population.     

熔盐蒸发器管板封口焊缝泄漏原因分析

某光热电站熔盐蒸发器入口侧管板封口焊缝发生泄漏,通过表面检测和观察,发现裂纹是从封口焊缝根部发展,并从根部向外扩展的。根据裂纹扩展方向和运行数据进行综合分析认为,熔盐蒸发器在未正确操作下导致在极短时间内管板下部表面升温过快,造成封口焊缝局部热应力过大。在焊缝残余应力、工作应力和热应力共同作用下,管板下部封口焊缝根部产生裂纹并扩展至焊缝表面,形成贯穿性裂纹,造成蒸发器管板泄漏。     

Research on targeted land poverty alleviation patterns based on the precise identification of dominant factors of rural poverty: a case study of Siyang County,Jiangsu Province,China

Environment, Development and Sustainability - Poverty is a common problem faced by various social and economic forms. Eliminating poverty is a major issue of common concern and research all over...     

“阳光体育”背景下学校体育管理变革利益分析

从"阳光体育"助推学校体育管理变革出发,借鉴和运用利益相关者理论,分析我国学校体育管理变革的逻辑基础以及划分出不同的利益相关者,指出学校体育管理变革实质上就是各利益相关者之间利益博弈或行为协作的制度变迁过程,其结果是各利益相关者对学校体育资源及其附属品的再分配,其中利益冲突是变革的核心内容,而造成利益冲突的原因是多方面的。走向利益均衡是学校体育管理变革的基本价值取向。     

A field study of the relationship between sulfide-bound metals and bioaccumulation by Limnodrilus sp. in a heavily polluted river

Acid volatile sulfide (AVS) has been regarded as an important factor controlling metal bioavailability in anoxic sediments, but its effect on metal accumulation under natural conditions is poorly understood. Here, a field study of the influence of AVS on metal accumulation by Limnodrilus sp. in a heavily polluted river is provided. Most of the study area was subject to anaerobic and strongly reducing conditions, and the concentration of trace metals in surface sediments was high, as were the concentration of AVS and simultaneously extracted metals (SEM; average AVS?=?20.3 μmol g^?1, average ∑SEM₅?=?9.42 μmol g^?1; ∑SEM₅ refers to the sum of SEM_Cd, SEM_Cu, SEM_Pb, SEM_Ni, and SEM_Zn). Only a few species and small quantities of benthic invertebrates were found, and Limnodrilus sp. was dominant. There was no correlation between trace metal accumulation and (SEM-AVS), and in stations where (SEM-AVS) <0, the absolute value of bioaccumulation was high (average ∑BIO₅?=?4.07 μmol g^?1; ∑BIO₅ refers to the sum of BIO_Cd, BIO_Cu, BIO_Pb, BIO_Ni, and BIO_Zn), indicating that there was no relationship between (SEM–AVS) and metal accumulation in Limnodrilus sp. This was likely because Limnodrilus sp. ingest sediment particles as their main food source, so pore water metals play a minor role in their bioaccumulation (BIO) of materials. However, ∑BIO₅ was significantly correlated with ∑SEM₅ (r?=?0.795, p?<?0.01), revealing that the large number of sulfide-bound metals (SEM) in sediments may play an important role in metal accumulation in Limnodrilus sp., which can assimilate sulfide-associated metals by the help of the digestive fluids in the digestive systems.     

Grey optimization Verhulst model and its application in forecasting coal-related CO2 emissions

Environmental Science and Pollution Research - Energy saving and emission reduction are the most concerned issues in the world. Objective and accurate prediction of carbon emissions can provide...     

Environmental significance of biogenic elements in surface sediments of the Changjiang Estuary and its adjacent areas

Biogenic elements and six phosphorus(P) fractions in surface sediments from the Changjiang Estuary and adjacent waters were determined to investigate the governing factors of these elements, and further to discuss their potential uses as paleo-environment proxies and risks of P release from sediment. Total organic carbon(TOC) and leachable organic P(Lea-OP) showed high concentrations in the estuary, Zhejiang coast and ofshore upwelling area. They came from both the Changjiang River and marine biological input.Biogenic silicon(BSi) exhibited a high concentration band between 123 and 124°E. BSi mainly came from diatom production and its concentration in the inshore area was diluted by river sediment. Total nitrogen(TN) was primarily of marine biogenic origin. Seaward decreasing trends of Fe-bound P and Al-bound P revealed their terrestrial origins. Influenced by old Huanghe sediment delivered by the Jiangsu coastal current, the maximum concentration of detrital P(Det-P) was observed in the area north of the estuary. Similar high concentrations of carbonate fluorapatite(CFA-P) and CaCO3 in the southern study area suggested marine calcium-organism sources of CFA-P. TOC, TN and non-apatite P were enriched in fine sediment, and Det-P partially exhibited coarse-grain enrichment, but BSi had no correlation with sediment grain size. Diferent sources and governing factors made biogenic elements and P species have distinct potential uses in indicating environmental conditions. Transferable P accounted for 14%-46% of total P. In an aerobic environment,there was low risk of P release from sediment, attributed to excess Fe oxides in sediments.     

辽河源头区畜禽养殖粪便处理处理现状及对策初探

本文以畜禽养殖较为集中、污染问题较为突出的辽河源头区为研究区域,通过流域内畜禽污染物排放方式,污染物排放总量,总结流域内畜禽养殖污染特点,在次基础上提出切实可行的畜禽污染防治对策,为相关政策的制定提供依据。     

基于水质模型的污染监控预警和应急管理研究

地表水环境的治理和改善受到社会、经济、环境等多方面因素的共同影响,如何合情、合理地制定地表水污染防治政策、规划,在复杂的水环境污染突发事件中及时掌握事态的发展和正确的处理处置方法是我国各级环境保护管理部门面临的一大难题。本论文以建立水质污染扩散模型为基础,结合我国地表水环境管理现状提出了一套地表水污染监控预警和应急管理体系,旨在建立废水污染源与地表水环境质量的内在联系,用科学的方法为地表水污染防治管理工作提供技术支撑。     

Insight into removal of dissolved organic matter in post pharmaceutical wastewater by coagulation-UV/H2O2

The removal of four dissolved organic matter (DOM) fractions, non-acid hydrophobics, hydrophobic acids, hydrophilics and transphilics, was achieved by coagulation-UV/H₂O₂ oxidation in post-pharmaceutical wastewater (PhWW). Coagulation with Polyferric chloride (PFC), Polymeric ferric sulfate (PFS) and Polymeric aluminum ferric chloride (PAFC) was studied separately to evaluate the effects of the initial pH and coagulant dosage. The coagulation-UV/H₂O₂ oxidation method resulted in much higher reduction rates for dissolved organic carbon (DOC) (by 75%) and UV₂₅₄ (by 92%) than coagulation or UV/H₂O₂ oxidation alone. The proportion of non-acid hydrophobics, hydrophobic acids, transphilics and hydrophilics removed by coagulation was 54%, 49%, 27% and 12 %, while the combined treatment removed 92%, 87%, 70% and 39%, respectively. Parallel factor analysis (PARAFAC) of fluorescence measurements revealed that the humic-like fluorescent component C4 showed the highest removal (by 44%) during the coagulation stage. After coagulation-UV/H₂O₂ treatment, the humic-like fluorescent component C3 had the highest removal (by 72%), whereas xenobiotic organic fluorescent components C1 and C4 remained recalcitrant to decomposition. Significant correlations (R² > 0.8) between C1 and the hydrophobic acids and non-acid hydrophobics suggested the possibility of using fluorescence spectroscopy as an effective tool to assess variations in DOM fraction treatment efficacy in coagulation-UV/H₂O₂ systems. After the combined treatment, toxic inhibition of cellular activity by post PhWW decreased from 88% to 47% and biodegradability increased from 0.1 to 0.52.