Accommodation of climate change in coastal areas of cameroon: selection of household-level protection options

Coastal areas are threatened under climate change because of factors related to vulnerability of society and sensitivity of the environment. Protection and adaptation may mitigate the adverse consequences. This research reviews and assesses the options of protection by homeowners in the coastal zone in the southwest region of Cameroon. The coastal zone of Cameroon is studied because of the observed deleterious effect of recent extreme climatic events. From a research sample of 400 households, the house types and protection strategies - which are of two main types: reactive measures and preventive measures taken to offset adverse effects on property, are studied. A multinomial logit function reveals that income, education, age and gender are significant factors determining household’s probability on the selection of protection measures. The study concludes that there are strong implications for adaptation to future climate change, and the ability of homeowners to extensively respond will have to be reinforced not only by communal and public works projects but also through an active government policy to promote climate change adaptation.     

Prognostic accuracy of factors associated with poor outcome in prenatally diagnosed sacrococcygeal teratoma: A systematic review and meta-analysis

Several factors associated with poor outcome in patients with prenatally diagnosed sacrococcygeal teratoma (SCT) have been found. However, the prognostic accuracy of these factors has not been well established. Therefore, we aimed to systematically review the prognostic accuracy of factors associated with poor outcome in these patients. We queried Search Premier, COCHRANE Library, EMCARE, EMBASE, PubMed, ScienceDirect, and Web of Science databases to identify studies regarding patients with prenatally diagnosed SCT. Poor outcome was defined as termination of pregnancy (TOP), intrauterine fetal death (IUFD), or perinatal death. We estimated the odds ratio of factors associated with poor outcome. Eleven studies (447 patients) were included. Overall mortality, including TOP, was 34.9%. Factors associated with poor outcome in fetuses with prenatally diagnosed SCT were cardiomegaly, hypervascular tumor, solid tumor morphology, fetal hydrops, and placentomegaly. A tumor volume to fetal weight ratio (TFR) of >0.12 before a gestational age of 24 weeks is predictive of poor outcome. The prognostic accuracy of factors associated with poor outcome in fetuses prenatally diagnosed with SCT seems promising. Factors associated with cardiac failure such as cardiomegaly, hypervascular tumor, solid tumor morphology, fetal hydrops, placentomegaly, and TFR >0.12 were found to be predictive of poor outcome.     

The imprecision in rates of down syndrome by 1-year maternal age intervals: A critical analysis of rates used in biochemical screening

Current algorithms to determine eligibility for prenatal cytogenetic diagnostic services depend critically on the accuracy and precision of the underlying rates of cytogenetic abnormality used in the calculations. We examine the maternal age-specific rates of Down syndrome livebirths in eight studies of European-origin populations, pooled rates from which are widely used for baseline calculations in biochemical screening. These studies vary significantly in such factors as methods of ascertainment of cases, likelihood of complete ascertainment, and methods of correction, if any, for underascertainment. Restriction of analysis to those two studies among the eight whose methods suggest the greatest likelihood of complete ascertainment for Down syndrome generates rates significantly higher than those in widespread use. Confidence intervals about previously reported and currently derived rates indicate that even with large-scale data, there is considerable residual uncertainty in derived rates.     

Book Reviews

CARCINOGENESIS AND MUTAGENESIS, by Myron A. Mehlman, Morris F. Cranmer and Raymond E. Shapiro, from the Journal of Environmental Pathology and Toxicology (Official Organ of the American College of Toxicology), 388 pages and 135 tables and figures, 1977, linen, format 261 × 178 mm, ISBN 0–930376–02–1, printed by Pathotox Publishers, Inc., Park Forest South, Illinois 60466, $23.00

WASTE TREATMENT AND UTILIZATION (Theory and Practice of Waste Management) by Murray Moo‐Young and Grahame J. Farquhar, University of Waterloo, Ontario, Canada; 574 pages, 211 illustrations and 513 literature references, linen, format 256 × 182mm, ISBN 0–08–023831–9, printed by Pergamon Press Ltd., Oxford OX3 OBW, England 1979, US$ 70.00 or £32.00.

HANDBOOK ON THE TOXICOLOGY OF METALS by Lars Friberg (S‐10401 Stockholm), Gunnar F. Nordberg (DK‐5000 Odense) and Velimir B. Vouk (WHO, CH‐1211 Geneva), and sponsored by the U.S. Environmental Protection Agency 1979, 709 pages, linen, format 246 × 173 mm, ISBN 0–444–80075–1, printed by Elsevier/North‐Holland Biomedical Press, Amsterdam NL, $117.00/Dfl. 240.00     

Perfluorocarbon background concentrations in Europe

Five studies of the background level of several perfluorocarbon compounds in Europe are here presented together with measurements from the European Tracer Experiment (ETEX). The tracers used during the two ETEX tracer releases were the perfluorocarbons (PFCs); perfluoromethylcyclohexane (C₇F₁₄, PMCH) and perfluoromethylcyclopentane (C₆F₁₂, PMCP). Their background concentrations were detected by using both passive and active sampling techniques, to define the spatial and temporal variation of the PFCs over Europe. Also the background variations of four isomers of the PFC compound perfluorodimethylcyclohexane (C₈F₁₆, PDCH) were studied. The results were compared to other PFC tracer studies in the U.S.A. and Europe. The mean and median values of the measured PFCs were found to vary slightly and randomly in space and time. They were found to be higher and to have a larger standard deviation than the measurements from the American studies. The background concentrations were still found to be low and stable enough for PFCs to be highly suitable for use in tracer studies. The following concentrations were found: PMCP; 4.6±0.3 fl ℓ^-1, PMCH: 4.6±0.8 fl ℓ^-1, ocPDCH: 0.96±0.33 fl ℓ^-1, mtPDCH: 9.3±0.8 fl ℓ^-1, mcPDCH: 8.8±0.8 fl ℓ^-1, ptPDCH: 6.1±0.8 fl ℓ^-1. A study of the correlation between the measured PFC compounds showed a significant correlation between most of the compounds, which indicate that there are no major PFC sources in Europe.     

Proposed guidelines for diagnosis of chromosome mosaicism in amniocytes based on data derived from chromosome mosaicism and pseudomosaicism studies

Currently, accepted protocol which has been developed at the Prenatal Diagnosis Laboratory of New York City (PDL) requires that when a chromosome abnormality is found in one or more cells in one flask, another 20–40 cells must be examined from one or two additional flasks. Chromosome mosaicism is diagnosed only when an identical abnormality is detected in cells from two or more flasks. In a recent PDL series of 12 000 cases studied according to this protocol, we diagnosed 801 cases (6.68 per cent) of single-cell pseudomosaicism (SCPM), 126 cases (1.05 per cent) of multiple-cell pseudomosaicism (MCPM), and 24 cases (0.2 per cent) of true mosaicism. Pseudomosaicism (PM) involving a structural abnormality was a frequent finding (2/3 of SCPM and 3/5 of MCPM), with an unbalanced structural abnormality in 55 per cent of SCPM and 24 per cent of MCPM. We also reviewed all true mosaic cases (a total of 50) diagnosed in the first 22000 PDL cases. Of these 50 cases, 23 were sex chromosome mosaics and 27 had autosomal mosaicism; 48 cases had numerical abnormalities and two had structural abnormalities. Twenty-five cases of mosaicism were diagnosed in the first 20 cells from two flasks, i.e., without additional work-up, whereas the other 25 cases required extensive work-up to establish a diagnosis (12 needed additional cell counts from the initial two culture flasks; 13 required harvesting a third flask for cell analysis). Our data plus review of other available data led us to conclude that rigorous efforts to diagnose true mosaicism have little impact in many instances, and therefore are not cost-effective. On the basis of all available data, a work-up for potential mosaicism involving a sex chromosome aneuploidy or structural abnormality should have less priority than a work-up for a common viable autosomal trisomy. We recommend revised guidelines for dealing with (1) a numerical versus a structural abnormality and (2) an autosomal versus a sex chromosome numerical aneuploidy. Emphasis should be placed on autosomes known to be associated with phenotypic abnormalities. These new guidelines, which cover both flask and in situ methods, should result in more effective prenatal cytogenetic diagnosis and reduced patient anxiety.     

A simple model for describing the concentration of 212Pb in the atmosphere

The implementation of the Comprehensive Test Ban Treaty is resulting in the construction of a world-wide system of 80 monitoring stations that will be able to detect air-borne radioactivity, not only from atomic bombs but also from other anthropogenic and natural sources. A prototype monitoring station has been operating since April 1996 in Vancouver, BC, Canada. This station provides daily reports of natural radioactivity, including 7Be and decay products of 220Rn (thoron). Data for 212Pb concentrations have been analyzed over a 6-month period. The concentration is reduced by rainfall, high wind velocity, and low temperatures and it also depends on the wind direction, but atmospheric inversions appeared to have little impact. We present a relatively simple model, which is easy to use and which offers predictive powers that can be applied to other similar environmental situations.