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A. H. El‐Shaarawi 《Environmetrics》2002,13(7):801-802
I welcome this article as it sheds new light on the important but difficult problem of the identification of pollution sources and the estimation of their contributions from field monitoring data. The article raises a number of technical issues, which are pertinent to the use of its methods in applications. In particular, a number of assumptions are used but without indicating how they can be tested from the data. I will confine my comments to: (a) the model specification and how it might be used in practice; (b) the estimation of the model's parameters. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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The present paper reviews the important contributions of Ian MacNeill to the theory and methodology of change‐point analysis and environmental statistics. The review concentrates on four areas of change‐point analysis: sequences of independent random variables; linear regression models with independent as well as serially correlated random errors; regression models with continuity constraints and spatial models of change‐points. Copyright © 1999 John Wiley & Sons, Ltd. 相似文献
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A wide spectrum of genetic causes may lead to nonimmune hydrops fetalis (NIHF), and a thorough phenotypic and genetic evaluation are essential to determine the underlying etiology, optimally manage these pregnancies, and inform discussions about anticipated prognosis. In this review, we outline the known genetic etiologies of NIHF by fetal organ system affected, and provide a systematic approach to the evaluation of NIHF. Some of the underlying genetic disorders are associated with characteristic phenotypic features that may be seen on prenatal ultrasound, such as hepatomegaly with lysosomal storage disorders, hyperechoic kidneys with congenital nephrosis, or pulmonary valve stenosis with RASopathies. However, this is not always the case, and the approach to evaluation must include prenatal ultrasound findings as well as genetic testing and many other factors. Genetic testing that has been utilized for NIHF ranges from standard chromosomal microarray or karyotype to gene panels and broad approaches such as whole exome sequencing. Family and obstetric history, as well as pathology examination, can yield additional clues that are helpful in establishing a diagnosis. A systematic approach to evaluation can guide a more targeted approach to genetic evaluation, diagnosis, and management of NIHF. 相似文献
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