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541.
The identification of cell-free fetal DNA circulating in maternal blood combined with technological developments, in particular next-generation sequencing, is enabling the development of safer prenatal diagnosis. While this technology has been widely applied as a highly sensitive screening test for aneuploidy, there has been relatively little clinical application for the diagnosis of monogenic disorders. In the UK, we have established non-invasive prenatal diagnosis (NIPD) as a clinical service for a range of inherited disorders. The results from NIPD do not require confirmation by invasive testing and are welcomed by patients and health professionals alike. Here, we describe the technical approaches used, current practice and outline recommendations for best practice when delivering an NIPD service from an accredited laboratory. © 2017 John Wiley & Sons, Ltd. 相似文献
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With increased outsourcing and environmental consciousness, this paper presents an analytic network process (ANP) approach to incorporate the issue of hazardous substance management (HSM) into supplier selection. In this study, identification of criteria of HSM competence is categorized into four dimensions, a multi-criteria decision model is proposed. ANP is then applied to supplier selection and is characterized by interdependencies among decision structure components. An illustrative example in an electronics company is presented to demonstrate how to select a most appropriate supplier in accordance with the requirements of hazardous substance for environmental regulations. 相似文献
544.
Kevin W. King R. Daren Harmel H. Allen Torbert James C. Balogh 《Journal of the American Water Resources Association》2001,37(3):629-640
ABSTRACT: Turfgrass systems are one of the most intensively managed land uses in the United States. Establishment and maintenance of high quality turfgrass usually implies substantial inputs of water, nutrients, and pesticides. The focus of this work was to quantify the concentration and loading of a typically maintained municipal turfgrass environment on surface water. Water quantity and quality data were collected from a golf course in Austin, Texas, and analyzed for a 13‐month period from March 20, 1998, to April 30, 1999. Twenty‐two precipitation events totaling 722 mm, produced an estimated 98 mm of runoff. Nutrient analysis of surface runoff exiting the course exhibited a statistically significant (p < 0.05) increase in median nitrate plus nitrite nitrogen (NO3+NO2‐N) concentration compared to runoff entering the course, a statistically significant decrease in ammonia nitrogen (NH4‐N), but no difference in orthophosphate (PO4‐P). During the 13‐month period, storm runoff contributed an estimated 2.3 kg/ha of NO3+NO2‐N and 0.33 kg/ha of PO4‐P to the stream. Storm flow accounted for the attenuation of 0.12 kg/ha of NH4‐N. Baseflow nutrient analysis showed a statistically significant increase in median NO3+NO2‐N, a significant reduction in NH4‐N, and no change in PO4‐P. Estimated NO3+NO2‐N mass in the baseflow was calculated as 4.7 kg/ha. PO4‐P losses were estimated at 0.06 kg/ha, while 0.8 kg/ha of NH4‐N were attenuated in baseflow over the study period. Even though nutrient concentrations exiting the system rarely exceeded nutrient screening levels, this turfgrass environment did contribute increased NO3+NO2‐N and PO4‐P loads to the stream. This emphasizes the need for parallel studies where management intensity, soil, and climate differ from this study and for golf course managers to utilize an integrated management program to protect water quality while maintaining healthy turfgrass systems. 相似文献
545.
Patterns of species turnover may reflect the processes driving community dynamics across scales. While the majority of studies on species turnover have examined pairwise comparison metrics (e.g., the average Jaccard dissimilarity), it has been proposed that the species-area relationship (SAR) also offers insight into patterns of species turnover because these two patterns may be analytically linked. However, these previous links only apply in a special case where turnover is scale invariant, and we demonstrate across three different plant communities that over 90% of the pairwise turnover values are larger than expected based on scale-invariant predictions from the SAR. Furthermore, the degree of scale dependence in turnover was negatively related to the degree of variance in the occupancy frequency distribution (OFD). These findings suggest that species turnover diverges from scale invariance, and as such pairwise turnover and the slope of the SAR are not redundant. Furthermore, models developed to explain the OFD should be linked with those developed to explain species turnover to achieve a more unified understanding of community structure. 相似文献
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Rochelle Constantine Debbie Steel Judy Allen Megan Anderson Olive Andrews C. Scott Baker Peta Beeman Daniel Burns Jean-Benoît Charrassin Simon Childerhouse Michael Double Paul Ensor Trish Franklin Wally Franklin Nick Gales Claire Garrigue Nadine Gibbs Peter Harrison Nan Hauser Amanda Hutsel Curt Jenner Micheline-Nicole Jenner Greg Kaufman Anne Macie David Mattila Carlos Olavarría Adrian Oosterman David Paton Michael Poole Jooke Robbins Natalie Schmitt Peter Stevick Alden Tagarino Kirsten Thompson Juney Ward 《Marine Biology》2014,161(5):1087-1093
Understanding the dynamics of population recovery is particularly complex when an organism has multiple, remote breeding and feeding grounds separated by one of the longest known migration routes. This study reports on the most comprehensive assessment of humpback whale (Megaptera novaeangliae) movements between remote Antarctic waters south of New Zealand and east Australia (EA), and the migratory corridors and breeding grounds of Australia and Oceania. A total of 112 individual whales were identified; 57 from microsatellites and 61 by fluke with 23 % (n = 26) matched to sites outside Antarctica. Despite large datasets from other southern regions being included in the comparison, the whales were predominantly linked to EA (n = 24). Only two matches to the Oceania catalogues directly north was surprising; therefore the primary feeding grounds of these endangered whales still remain unknown. The confirmation of the Balleny Islands as an important feeding ground for EA whales could provide an insight into reasons behind the rapid recovery of this population. Determining the feeding grounds of Oceania’s whales may explain whether prey energetics or migration length are limiting factors to their recovery and will allow an understanding of future ecosystem changes in these whales. 相似文献
549.
Karen A. Bjorndal Barbara A. Schroeder Allen M. Foley Blair E. Witherington Michael Bresette David Clark Richard M. Herren Michael D. Arendt Jeffrey R. Schmid Anne B. Meylan Peter A. Meylan Jane A. Provancha Kristen M. Hart Margaret M. Lamont Raymond R. Carthy Alan B. Bolten 《Marine Biology》2013,160(10):2711-2721
In response to a call from the US National Research Council for research programs to combine their data to improve sea turtle population assessments, we analyzed somatic growth data for Northwest Atlantic (NWA) loggerhead sea turtles (Caretta caretta) from 10 research programs. We assessed growth dynamics over wide ranges of geography (9–33°N latitude), time (1978–2012), and body size (35.4–103.3 cm carapace length). Generalized additive models revealed significant spatial and temporal variation in growth rates and a significant decline in growth rates with increasing body size. Growth was more rapid in waters south of the USA (<24°N) than in USA waters. Growth dynamics in southern waters in the NWA need more study because sample size was small. Within USA waters, the significant spatial effect in growth rates of immature loggerheads did not exhibit a consistent latitudinal trend. Growth rates declined significantly from 1997 through 2007 and then leveled off or increased. During this same interval, annual nest counts in Florida declined by 43 % (Witherington et al. in Ecol Appl 19:30–54, 2009) before rebounding. Whether these simultaneous declines reflect responses in productivity to a common environmental change should be explored to determine whether somatic growth rates can help interpret population trends based on annual counts of nests or nesting females. Because of the significant spatial and temporal variation in growth rates, population models of NWA loggerheads should avoid employing growth data from restricted spatial or temporal coverage to calculate demographic metrics such as age at sexual maturity. 相似文献
550.
Allen H. Hu Ching-Yao Huang Chi-Fu Chen Chien-Hung Kuo Chia-Wei Hsu 《国际发展与全球生态学杂志》2013,20(4):313-323
The accommodation sector is the most demanding energy consumer among all building stock categories. This study quantifies an international tourist hotel in Taiwan to holistically estimate the greenhouse gas emissions of hotel accommodation services through a complete life cycle inventory. The study also investigates the difference between the carbon emissions of the baseline and reduction years to understand the effects of carbon emission reduction on the hotel industry. Results show that energy consumption is the main source of carbon footprint. However, the carbon emissions of other activities, such as the production and transportation of hotel amenities and laundry services, are 15.90% for the baseline year and 16.03% for the reduction year. These values are larger than the 5% cutoff rule according to PAS 2050. Thus, these factors should also be considered in assessing the carbon emissions of accommodation services. Hotel occupancy rate significantly affects carbon emissions during a one-night stay in a standard room as the functional unit. The selection of the functional unit should be considered in the hotel strategy. Although this case study involves an international tourist hotel in Taiwan, the findings and recommendations for improvements can be applied elsewhere. 相似文献