Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien

Bacterial cell wall components such as lipopolysaccharide, a variety of membrane proteins, murein, and lipoprotein can act as immunoadjuvants for bacterial vaccines, thus enhancing protection from bacterial infections. Synthetically prepared N-terminal parts of the lipoprotein from Enterobacteria carrying three fatty acid residues or lipopeptide analogs containing one to four aminoacids bound to S-glycerylcysteine act as potent immunoadjuvants in vivo in combination with or covalently linked to antiges. Here we demonstrate that the supplementation ofSalmonella vaccines with these synthetic lipopeptides significantly enhances their vaccine efficiency in mice. Variations in the native lipopeptide structure regarding chain length and amino acid sequence of the peptide moiety, as well as modifications of the lipoamino acid, lead to reduction or even complete loss of the adjuvant activity. The immunoadjuvant properties of the lipopeptides as described here are mediated by an enhancement of the humoral immune response.     

Nachhaltige Entwicklung von Managementstrategien: Multikriterielle Bewertungs- und Entscheidungshilfe-Instrumente im Umweltbereich

Zur Unterstützung von Bewertungs- und Entscheidungsprozessen über die Nachhaltigkeit von Managementstrategien, deren Auswirkungen durch unterschiedlich dimensionierte Indikatoren gemessen werden, gibt es verschiedene mathematische Methoden. In diesem Beitrag werden die Prinzipien dieser sog. multikriteriellen Bewertungs- und Entscheidungshilfeinstrumente beispielhaft anhand einer Auswahl von Strategien für ein Nachhaltiges Wassermanagement vorgestellt, sowie Vor- und Nachteile herausgearbeitet. Es wird gezeigt, dass sich die Verfahren insbesondere in Transparenz, Objektivit?t und durch den Grad an Partizipation durch Akteure z.T. erheblich unterscheiden. W?hrend die Hassediagrammtechnik sich an den naturwissenschaftlich begründbaren Datenmatrix orientiert und somit eine objektive und transparente Bewertung und Datenanalyse liefert, haben Konkordanzanalyse, Nutzwertanalyse, PROMETHEE und AHP ihre St?rken in der M?glichkeit, Akteure bzw. Stakeholder am Entscheidungsprozess partizipieren zu lassen. *** DIRECT SUPPORT *** A00OI029 00003     

Genetic engineering for practical application

Genetic engineering has ushered in a new era in biology. Although many problems are still to be solved, there are examples that point to a possible later application for the benefit of mankind: Bacteria can be manipulated to degrade crude-oil spillages, to produce human insulin and to bind nitrogen from the air. If all the bacteria that are indigenous to agricultural soils could be made to bind nitrogen, an increase in soil fertility might well result.     

Quantitative Bestimmung des lokalen Flusses mit elektrochemisch erzeugtem Wasserstoff

The Science of Nature -     

Sekundärrohstoffe aus Abfall-Lösungen

Every year about 40 000 m³ of waste solutions from photographic fixing and developing processes are produced in Germany. A new method of reclaiming some base chemicals (silver, fixing salt, gypsum and ammonia) from these solutions has been developed for black and white photographic processes. The remaining waste water has a low COD-value and low concentration of dissolved salts. This method is considered further to develop the state-of-the-art technique and is economically feasible.     

A critical review of the water quality classification system in Turkey: A case study on Meric Basin

An 11-year period of water quality data, collected by the Directorate of Sate Water Works of Turkey are thoroughly analyzed for the purpose of implementing water quality classes to water resources in the Meric Basin, located on the European land mass of Turkey. Water quality parameters are divided into four groups as physical, organic, inorganic, and bacteriological. The quality class of each group is evaluated by taking into account the poorest quality of any parameter in the group, after which a quality rank is assigned to the sampling station and the waterbody in question. This method of water quality classification imposed by the Turkish Water Quality Act, is then criticized with respect to a statistical approach.