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41.
Bo B. Bet Maartje C. Snoep Elisabeth van Leeuwen Ingeborg H. Linskens Monique C. Haak Lieke Rozendaal Ingmar Knobbe Joost van Schuppen Carlijn E. L. Hoekstra David R. Koolbergen Sally-Ann Clur Eva Pajkrt 《黑龙江环境通报》2023,43(5):629-638
Objectives
To determine the proportion of children that require surgery in the first year of life and thereafter in order to improve the counseling of parents with a fetus with a right aortic arch (RAA).Methods
Fetuses diagnosed with isolated RAA, defined as the absence of intra- or extracardiac anomalies, between 2007 and 2021 were extracted from the prospective registry PRECOR.Results
In total, 110 fetuses were included, 92 with a prenatal diagnosis of RAA and 18 with double aortic arch (DAA). The prevalence of 22q11 deletion syndrome was 5.5%. Six pregnancies were terminated and five cases were false-positive; therefore, the follow-up consisted of 99 neonates. Surgery was performed in 10 infants (10%) in the first year of life. In total, 25 (25%) children had surgery at a mean age of 17 months. Eight of these 25 (32%) had a DAA. Only one child, with a DAA, required surgery in the first week of life due to obstructive stridor.Conclusions
Children with a prenatally diagnosed RAA are at a low risk of acute respiratory postnatal problems. Delivery in a hospital with neonatal intensive care and pediatric cardiothoracic facilities seems only indicated in cases with suspected DAA. Expectant parents should be informed that presently 25% of the children need elective surgery and only incidentally due to acute respiratory distress. 相似文献42.
Fleur Zwanenburg Arend D. J. Ten Harkel Maartje C. Snoep Bo B. Bet Ingeborg H. Linskens Ingmar Knobbe Eva Pajkrt Nico A. Blom Sally-Ann B. Clur Monique C. Haak 《黑龙江环境通报》2023,43(5):620-628
Objective
We aimed to assess current prenatal detection rate (DR) of aortic coarctation (CoA) and its impact on neonatal outcome in the Netherlands to evaluate the efficacy of the Dutch screening protocol in which the cardiac four-chamber view, outflow tracts and three-vessel view are compulsory.Methods
All prenatally and postnatally diagnosed CoA cases between 2012 and 2021 were extracted from our PRECOR-registry. Annual DRs were calculated with a focus on the trend over time and attributing factors for detection. Postnatal outcome was compared between prenatally detected and undetected cases.Results
49/116 cases (42.2%) were detected prenatally. A higher chance of detection was found for cases with extracardiac malformations (71.4%; p = 0.001) and the more severe cases with an aortic arch hypoplasia and/or ventricular septal defect (63.2%; p = 0.001). Time-trend analysis showed no improvement in DR over time (p = 0.33). Undetected cases presented with acute circulatory shock in 20.9% and were more likely to have severe lactic acidosis (p = 0.02) and impaired cardiac function (p < 0.001) before surgery.Conclusion
Even in a well-organized screening program, the DR of CoA still requires improvement, especially in isolated cases. The increased risk of severe lactic acidosis in undetected cases stresses the need for urgent additions to the current screening program, such as implementation of the three-vessel trachea view and measurement of outflow tracts. 相似文献43.
The lower troposphere is an excellent receptacle, which integrates anthropogenic greenhouse gases emissions over large areas. Therefore, atmospheric concentration observations over populated regions would provide the ultimate proof if sustained emissions changes have occurred. The most important anthropogenic greenhouse gas, carbon dioxide (CO(2)), also shows large natural concentration variations, which need to be disentangled from anthropogenic signals to assess changes in associated emissions. This is in principle possible for the fossil fuel CO(2) component (FFCO(2)) by high-precision radiocarbon ((14)C) analyses because FFCO(2) is free of radiocarbon. Long-term observations of (14)CO(2) conducted at two sites in south-western Germany do not yet reveal any significant trends in the regional fossil fuel CO(2) component. We rather observe strong inter-annual variations, which are largely imprinted by changes of atmospheric transport as supported by dedicated transport model simulations of fossil fuel CO(2). In this paper, we show that, depending on the remoteness of the site, changes of about 7-26% in fossil fuel emissions in respective catchment areas could be detected with confidence by high-precision atmospheric (14)CO(2) measurements when comparing 5-year averages if these inter-annual variations were taken into account. This perspective constitutes the urgently needed tool for validation of fossil fuel CO(2) emissions changes in the framework of the Kyoto protocol and successive climate initiatives. 相似文献
44.
Anne Ingeborg Myhr 《Journal of Agricultural and Environmental Ethics》2010,23(6):501-525
The commercial introduction of genetically modified organisms (GMOs) has revealed a broad range of views among scientists
and other stakeholders on perspectives of genetic engineering (GE) and if and how GMOs should be regulated. Within this controversy,
the precautionary principle has become a contentious issue with high support from skeptical groups but resisted by GMO advocates.
How to handle lack of scientific understanding and scientific disagreement are core issues within these debates. This article
examines some of the key issues affecting precaution as a legal standard and as an approach to the use of science in decision-making
processes. It is pointed out that there is a need for reflection over the level of scientific evidence required for applying
the precautionary principle as well as who should have the burden of proof when there are uncertainties. Further, an awareness
of the broader scientific uncertainties found in GMO risk assessment implies that a precautionary approach must be elaborated:
both for acknowledging uncertainties and for identification of scientific responses. Since precaution is an important issue
within the sustainable development framework, it is suggested that sustainability can provide a normative standard that can
help to reveal the influence and negotiate the importance of the various forms of uncertainty. Wise management of uncertainties
and inclusion of normative aspects in risk assessment and management may help to ensure sustainable and socially robust GMO
innovations at present and in the future. 相似文献