Assessment of the toxicity of mixtures of halogenated dibenzo-p-dioxins and dibenzofurans by use of toxicity equivalency factors (TEF)

In March 1988 the authors completed a report on the risk assessment of mixtures of halogenated dibenzo-p-dioxins and dibenzofurans at the request of the National Institute of Public Health and Environmental Protection in the Netherlands. Based on a study of the current knowledge of these compounds, a set of toxicity equivalency factors was proposed for use in such risk assessments. This paper presents the section of this report that deals with the literature on the effects of these compounds and the choice of toxicity equivalency factors. The uncertanties in the selection and application of toxicity equivalency factors are discussed.     

A challenge to the assumed generalizability of prediction and countermeasure for risky driving: different factors predict different risky driving behaviors

In road safety, it may be debated whether all risky behaviors are sufficiently similar to be explained by similar factors. The often assumed generalizability of the factors that influence risky driving behaviors has been inadequately tested. Study 1 (N=116) examined the role of demographic, personality and attitudinal factors in the prediction of a range of risky driving behaviors, for young drivers. Results illustrated that different driving behaviors were predicted by different factors (e.g., speeding was predicted by authority--rebellion, while drink driving was predicted by sensation seeking and optimism bias). Study 2 (N=127) examined the generalizability of these results to the general driving population. Study 1 results did not generalize. Predictive factors remained behavior-specific, but different predictor-behavior relationships were observed in the community sample. Overall, results suggest that future research and practice should focus on a multi-factor framework for specific risky driving behaviors, rather than assuming generalizability across behaviors and driving populations.     

The respiratory metabolism of Tilapia mossambica (Teleostei)

In a series of experiments 174, 120 and 139 individuals of the teleost Tilapia mossambica (Peters), were acclimated to 30°C and to salinities of 0.4, 12.5 and 30.5, respectively. The effect of temperature and salinity upon oxygen consumption was studied by abruptly transferring fish of different wet weights to temperatures from 15° to 40°C at an average initial pO₂ of 250mm Hg. At each salinity, the proportionate response to temperature is size-independent. The metabolic rate increases as a function of temperature at 15° and 30°C but not at 40°C. Oxygen consumption is, however, salinity dependent; maximum rates are obtained at 12.5S. This salinity is isotonic in the 80 g fish and, to a lesser extent, in the 5 g fish. Reduction in osmotic load is suggested as the probable cause for a greater scope for activity and greater rate of oxygen consumption in 12.5 salinity.