II. Enhancement of gas transport in inositol hexaphosphate-loaded red blood cells

The gas-transport function of red blood cells which have incorporated inositol hexaphosphate is significantly improved by fusion with effector-loaded lipid vesicles. “Right-shifts” of the O₂-binding curves of inositol hexaphosphate-loaded red blood cells with half-saturation pressures at 37 °C up to 98 mmHg are observed. The transformation of 56% of the intracellular haemoglobin into the low affinity state corresponds to an optimum increase of the O₂-release capacity of 270%. The CO₂ transport is also correspondingly enhanced. The treated red blood cells show no inositol hexaphosphate depletion during a reasonable time.     

Better regulation by new governance hybrids? Governance models and the reform of European chemicals policy

The EU is presently in a transition phase from environmental policy-making by law towards other governance approaches based upon networking, voluntary commitments, benchmarking and other forms of “soft law”. Those new governance approaches often claim to lead to “better regulation”, while adopting a more consensus-oriented and participatory style, taking economic aspects more seriously into account, allowing for more flexibility and autonomy for the private sector and Member States alike, mobilising a broader knowledge base or adopting more integrated and holistic approaches than previous sectoralised and compartmentalised policies.While the limitations of traditional regulatory approaches are widely accepted and cited, it is far from evident, that “new modes of governance” have greater capacity to solve problems than the old ones. There is an argument, that “better regulation” might by synonymous to a withdrawal and weakening of the regulatory state and hence effectively of the aspirations and objectives of environmental policies.An interesting case for an approach, combining the strengths of the old and the new approaches is the ongoing reform of chemicals policies. While some observers claim, that the proposed directive, “REACH” might belong to the outdated category of overcomplex and bureaucratic regulation, a closer look shows that there are many new forms of governance in REACH. This mixture or old and new may open a more realistic and promising perspective on the reform of European policy-making.In our paper we assess the effects and the interplay of the combination of different modes of governance using the example of REACH. We are particularly concerned with the question in how far the representation of interests may change when new modes of governance are introduced.     

Ökologische Situation der Region Leipzig-Halle

Air pollution in the region Leipzig-Halle was investigated using two-year-old pine needles (Pinus sylvestris L.) at 39 sites of a biomonitoring net covering an area of ca. 7 500 km². The concentration values of Al, Ca, Cr, Fe, K, Mg, Mn, Pb and V characterize the immission patterns of the period 1990/91. The method is less suited for Cu, Ni and Zn due to the transfer route soil-pine, and for Cd due to the small total content. There are significant spatial and element-specific variations which require distinct evaluation of the pollution situation. The city of Leipzig itself is a significant source for Pb, Cr, Fe and V emission. Mainly as far as the centre of the region is concerned, the Pb concentration values are beyond those of heavily contaminated reference sites. The bioindication system is also applicable for comparable regions in Eastern Europe where the pine is the dominating conifer type. Immission trends can be monitored over ecologically relevant periods of time.