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101.
45,X/46,XX mosaicism was found in only one of four primary amniotic fluid cultures. Repeat amniocentesis revealed 45,X/46,XX mosaicism in all four primary cultures. Mosaicism was confirmed in tissues from the abortus. 相似文献
102.
This prospective study investigates the relationship between insulin-dependent diabetes and maternal serum levels of alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotropin (hCG). It also examines the potential impact on screening for Down syndrome. The population-based cohort included 20 321 pregnant women in Maine who underwent routine serum screening for Down syndrome in the second trimester. The cohort included 52 women with insulin-dependent diabetes. Maternal serum AFP levels are now routinely adjusted for insulin-dependent diabetes. These adjustments, therefore, were made routinely in the diabetic women, but no equivalent adjustments were made for uE3 and hCG values. The initial false-positive rate (using all three markers) among the women with diabetes was not significantly different from that in the non-diabetic population (7·7 and 5·4 per cent, respectively). Prior to adjustment for insulin-dependent diabetes, the median AFP level in the 52 women was 0·73 multiples of the median (MOM); the median levels of uE3 and hCG were 0·93 and 0·98 MOM, respectively. When the uE3 and hCG levels were adjusted, the initial false-positive rate was unchanged. Median serum levels of uE3 were significantly higher in the 33 women whose onset of diabetes was prior to 19 years of age (0·99 MOM) than in the 19 women whose onset of diabetes was at age 19 or older (0·84 MOM). This is the first population-based study to investigate the relationship between diabetes and serum levels of AFP, uE3, and hCG, and confirms earlier observations from a case—control study that found only slightly lower uE3 and hCG levels. 相似文献
103.
Glenn E. Palomaki B.S. James E. Haddow George J. Knight Nicholas J. Wald Anne Kennard Jacob A. Canick Devereux N. Saller Jr Miriam G. Blitzer Lois H. Dickerman Rachel Fisher Dagmar Hansmann Manfred Hansmann David A. Luthy Anne M. Summers Philip Wyatt 《黑龙江环境通报》1995,15(8):713-723
Nine centres collaborated to examine the feasibility of a screening method for trisomy 18 that was based on assigning individual risk, using a combination of maternal age and measurements of alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotropin (hCG). Second-trimester measurements of these analytes were obtained from 94 trisomy 18 pregnancies. In the 89 pregnancies without an associated open defect, the median levels for AFP, uE3, and hCG were 0.65, 0.43 and 0.36 multiples of the unaffected population median, respectively. The strongest individual predictor of risk for trisomy 18 was uE3, followed by hCG, AFP, and maternal age, in that order. Using a method of individual risk estimation that is based on the three markers and maternal age, 60 per cent of pregnancies associated with trisomy 18 would be detected at a risk cut-off level of 1:100, with a false-positive rate of about 0.2 per cent. One in nine pregnancies identified as being at increased risk for trisomy 18 would be expected to have an affected pregnancy. This risk-based screening method is more efficient than an existing method that is based on fixed analyte cut-off levels. Even though the birth prevalence of trisomy 18 is low, prenatal screening can be justified when performed in conjunction with Down syndrome screening and when a high proportion of women offered amniocentesis have an affected fetus. 相似文献
104.
Channel incision is a widespread phenomenon that results in stream and riparian habitat degradation. Fishes and physical habitat
variables were sampled at base flow from three incised stream channels and one reference stream in northwest Mississippi,
USA, to quantify incision effects on fish habitat and provide a basis for habitat rehabilitation planning and design. Incised
channels were sampled in spring and autumn; the reference channel was sampled only in the autumn. Incised channel habitat
quality was inferior to the reference channel despite the presence of structures designed to restore channel stability. Incised
channels had physical habitat diversity levels similar to a nonincised reference channel, but contained fewer types of habitat.
At base flow, incised channels were dominated by shallow, sandy habitats, moderate to high mean local Froude numbers, and
had relatively little organic debris in their beds. In contrast, the reference stream had greater mean water depth, contained
more woody debris, and provided more deep pool habitat. Fish assemblages in incised channels were composed of smaller fishes
representing fewer species relative to the reference site. Fish species richness was directly proportional to the mean local
Froude number, an indicator of the availability of pool habitat. 相似文献
105.
106.
Andrew T. Knight 《Conservation biology》2009,23(3):517-517
107.
Russell E. Keenan James W. Knight Elizabeth R. Rand Mary M. Sauer Bruce W. Found Frank H. Lawrence 《Chemosphere》1990,20(10-12)
Potential human and wildlife exposures to TCDD in landspread pulp and paper mill sludge in the State of Maine were evaluated by means of a human health and an ecological risk assessment methodology. The highest historical concentrations of TCDD reported for these sludges do not present a risk to American woodcock, selected as an indicator species for this analysis. Concentrations of TCDD as high as 50 ppt in soil are not likely to produce adverse effects in the embryonic/hatchling stage of the woodcock. This soil concentration of TCDD does not present a significant risk to sportsmen and their families that may consume birds which inhabit these sites. 相似文献
108.
109.
110.
Alexis Knight Satyendra P. Bhavsar Brian A. Branfireun Peter Drouin Ram Prasha Steve Petro Moustapha Oke 《环境科学学报(英文版)》2019,31(6):137-145
The use of biopsy plugs to sample fish muscle tissue for mercury analyses is a viable alternative to lethal sampling; however, the practice has yet to be widely implemented in routine monitoring due to concerns about variability of mercury concentrations in fish muscle tissues. Here we examine distribution of mercury in fillets of four fish species (Walleye, Northern Pike, Smallmouth Bass and Lake Trout), suitability of left/right side of fillet for biopsy sampling, and appropriateness of re-using a biopsy punch. The results showed that average mercury concentrations in left and right fillets of fish are similar. Mercury concentrations in biopsy plug samples, taken from the anterior dorsal area of the fish fillet, were statistically equivalent to the mercury concentrations in homogenized fillets. There was no discernible cross contamination between samples when a biopsy punch was reused after washing in hot soapy water, and as such, biopsy punches can be recycled during sampling to reduce the sampling cost. If a tissue mass collected from a specific site on the fillet is insufficient, then we suggest sampling corresponding locations on the other fillet rather than sampling two adjacent sites on one fillet to obtain more tissue. The results presented here can improve the accuracy of fillet biopsy plug sampling, minimize fish mortality for mercury monitoring, and reduce labor and material costs in monitoring programs. 相似文献