Is the Newly Described Vietnamese Bovid Pseudonovibos spiralis a Chamois (Genus Rupicapra)?

 The “Linh Duong” (Pseudonovibos spiralis), a newly described Vietnamese bovid, has been shown to be related to the Caprinae on the basis of the mitochondrial cytochrome b gene sequencing from horn fragments. To integrate the greatest available biodiversity we performed a new phylogenetic analysis including all genera of Caprinae. Unexpectedly, Pseudonovibos is found to be robustly associated with Rupicapra, and closer to the Alpine than to the Pyrenean chamois. Several clues led us to interpret this result as a carry-over DNA contamination of Pseudonovibos by Rupicapra. Received: 19 July 1999 / Accepted in revised form: 20 October 1999     

Glycine/serine ratio and the prenatal diagnosis of non-ketotic hyperglycinaemia

We describe our experience of prenatal diagnosis of non-ketotic hyperglycinaemia in four at-risk pregnancies using the glycine/serine ratio in amniotic fluid obtained between 18 and 20 weeks of gestation. All glycine levels were in the normal range. Serine levels were normal in two patients and borderline in the others. Glycine/serine ratios were normal in two patients, moderately increased in one patient ( + 3 SD), and highly increased in one patient ( + 8 SD). All the children were perfectly normal at birth. Because of this false-positive prediction and the false-negative prediction recently reported, we suggest that this unreliable method should not be used.