Prenatally diagnosed non-immune hydrops caused by congenital transient leukaemia

Congenital transient leukaemia (CTL) is a haematological disorder characterized by proliferation of myeloblasts within the bone marrow and peripheral blood of affected newborns. Infants with Down syndrome are most frequently affected and although the disorder can result in fetal death due to hydrops, it typically resolves spontaneously after birth. We present a case of prenatally diagnosed fetal hydrops accompanied by splenomegaly and an enlarged, echogenic liver in a fetus identified with CTL after birth.     

Volatile emissions from the flea beetle Altica litigata (Coleoptera: Chrysomelidae) associated with invasive Ludwigia hexapetala

The flea beetle Altica litigata (Chrysomelidae) is an insect herbivore to plants within the families Lythraceae and Onagraceae, including ornamentals such as crape myrtle, Lagerstroemia spp. This insect is important both as a pest species and as a naturally occurring biological control agent due to its aggregate feeding behavior, which typically results in severe defoliation of the host plant. Despite the negative economic impact to ornamentals and contrary benefits as a biological control agent, there are few reports on the semiochemical communication of this family of insects. Uruguayan primrose-willow (Ludwigia hexapetala) is an invasive aquatic weed in California and serves as a host to A. litigata. To better characterize this association, the volatile emissions of A. litigata were collected while the flea beetles were: in containers by themselves, in containers with L. hexapetala leaves, in situ on L. hexapetala leaves in a growth chamber, and in situ on L. hexapetala leaves in the field. For comparison, the volatile emissions of A. litigata associated with two subspecies of creeping water primrose (L. peploides) were also evaluated. Two himachalene-type sesquiterpenes, showing the same carbon skeleton as compounds previously reported from Aphthona flava and Epitrix fuscula, were detected as volatiles from A. litigata.     

Religious harassment in the workplace: An examination of observer intervention

Religious harassment claims in the United States have risen sharply over the past decade. However, victims of religious harassment may not always report harassment, and true rates may be higher. Hence, actions taken by third parties present (observers) are important in combating harassment in the workplace. The purpose of this paper is to extend a previous model of observer intervention and related research by testing it empirically in the context of religious harassment and identify factors that influence observers' decision to intervene (intervention), when they intervene (level of immediacy), and how much they intervene (level of involvement). Across two studies, we find evidence that verbal harassment, ambiguity of intent, relationship to target/harasser, recurrence belief, religious commitment, pro‐social orientation, and the interactive effect of shared religion and religious commitment predict intervention. Furthermore, individuals show higher levels of involvement and immediacy in intervention when costs are low and emotional reactions are high. Implications of these findings for engaging observers in combatting harassment are discussed. Copyright © 2015 John Wiley & Sons, Ltd.     

Thiourea leaching of gold from processed municipal solid waste incineration residues

Incineration is one of the key technologies in disposal of municipal waste, which produces municipal solid waste incineration (MSWI) residues with high valuable metal contents. The recycling strategy for the MSWI residues is typically focused on the recovery of scrap metals yielding processed municipal solid waste incineration residues (PIR) as the main byproduct. However, the PIR still contains valuable metals, particularly gold, which cannot be extracted by conventional methods. Here, we evaluated the feasibility of using the 0.5–2.0 mm grain size fraction of PIR containing 28.82 ± 1.62 mg/kg of gold as raw material for a two-stage extraction process. In the first stage the alkalic fine-grained PIR was acidified with a solution of 20% (v/v) of HCl-containing flue gas cleaning liquid that is obtained by the municipal waste incineration plant itself as a waste product. In the second stage we leached the acidified fine-grained PIR by thiourea with Fe³⁺ as an oxidant. Application of the thiourea-Fe³⁺ leaching system resulted in recovery of 16.4 ± 1.56 mg/kg of gold from the fine-grained PIR within 6 h of incubation. Due to high gold market prices, upscaling of the suggested technology can represent a suitable strategy for gold recovery from PIR and other MSWI residues.

     

Factors affecting the severity of injuries among young motorcyclists--a Swedish nationwide cohort study

OBJECTIVES: To determine factors affecting the severity of motorcycle injuries, considering variables related to the individual, the environment, the vehicle, and the crash. METHODS: This is a register-based retrospective cohort study. All individuals born in 1970-1972 (n = 334,070) were extracted from the Swedish Population and Housing Census of 1985 and followed up from 1988 to 2000, when aged 16-30. All subjects whose records indicated an injury as a motorcycle driver in the Swedish National Road Administration Accident Database were selected, and constituted the study population (n = 1,748). Factors related to the individual, the environment, the vehicle, and the crash were considered as exposure measures, whereas the outcome measure was the level of injury severity, based on assessments made on-site by police officers, in two categories: fatal/severe and minor. Associations between individual, environmental, vehicle and crash factors and injury severity were measured, using Chi-square, and through univariate and multivariate stepwise logistic regression. RESULTS: Factors such as alcohol consumption, traffic environment, speed limit, and type of crash were significantly associated (p < 0.0001) with injury severity. More specifically, a positive suspicion of alcohol consumption, driving in a rural area, and a posted speed limit over 50 km/hour were all factors positively associated (OR > 1.0) with the likelihood of being severely injured. On modeling all the variables together through stepwise logistic regression, positive suspicion of alcohol emerged as the strongest determinant (adjusted OR = 2.7) of a severe outcome. CONCLUSIONS. Motorcycle crashes still place a heavy burden on young drivers. Increased efforts are needed to prevent alcohol-related crashes-through law enforcement and a multiplicity of policies at local and national levels.     

Noninvasive prenatal screening for cystic fibrosis using circulating trophoblasts: Detection of the 50 most common disease-causing variants

Objectives

Cystic fibrosis (CF) is one of the most common severe autosomal recessive disorders. Prenatal or preconception CF screening is offered in some countries. A maternal blood sample in early pregnancy can provide circulating trophoblasts and offers a DNA source for genetic analysis of both the mother and the fetus. This study aimed to develop a cell-based noninvasive prenatal test (NIPT) to screen for the 50 most common CF variants.

Methods

Blood samples were collected from 30 pregnancies undergoing invasive diagnostics and circulating trophoblasts were harvested in 27. Cystic fibrosis testing was conducted using two different methods: by fragment length analysis and by our newly developed NGS-based CF analysis.

Results

In all 27 cases, cell-based NIPT provided a result using both methods in agreement with the invasive test result.

Conclusion

This study shows that cell-based NIPT for CF screening provides a reliable result without the need for partner- and proband samples.