The effect of humic acid in chronic deoxynivalenol intoxication

Environmental Science and Pollution Research - The most common mycotoxin found in European foodstuffs, especially unprocessed grains, is deoxynivalenol (DON), which inhibits proteosynthesis and...     

Microplastic abundance in beach sediments of the Kiel Fjord,Western Baltic Sea

Environmental Science and Pollution Research - We assessed the abundance of microplastics (0.2–5 mm) in drift line sediments from three sites in Kiel Fjord, Western Baltic...     

Effect of diosmin on lipid peoxidation and organ damage against subacute deltamethrin exposure in rats

Environmental Science and Pollution Research - The aim of this study was to investigate the protective efficacy of diosmin against subacute deltamethrin exposure. For this purpose, 40 male Wistar...     

Concentrations of selected trace elements in surface soils near crossroads in the city of Bratislava (the Slovak Republic)

Environmental Science and Pollution Research - It is well known that road transport emits various trace elements into the environment, which are deposited in soils in the vicinity of roads,...     

Ameliorative effects of deferiprone and tetraethylammonium salt of salinomycinic acid on lead-induced toxicity in mouse testes

Environmental Science and Pollution Research - In this study, we compare the effects of deferiprone (Def) and tetraethylammonium salt of salinomycinic acid (Sal) on lead (Pb)-induced toxicity in...     

Small-scale on-site treatment of fecal matter: comparison of treatments for resource recovery and sanitization

Environmental Science and Pollution Research - On-site small-scale sanitation is common in rural areas and areas without infrastructure, but the treatment of the collected fecal matter can be...     

Renewables as a pathway to environmental sustainability targets in the era of trade liberalization: empirical evidence from Turkey and the Caspian countries

Environmental Science and Pollution Research - The quest for improved environmental quality through low-carbon emission has been explored in this study in the wake of the growing call for a...     

Metabolomic analysis of the selection response of Drosophila melanogaster to environmental stress: are there links to gene expression and phenotypic traits?

We investigated the global metabolite response to artificial selection for tolerance to stressful conditions such as cold, heat, starvation, and desiccation, and for longevity in Drosophila melanogaster. Our findings were compared to data from other levels of biological organization, including gene expression, physiological traits, and organismal stress tolerance phenotype. Overall, we found that selection for environmental stress tolerance changes the metabolomic ¹H NMR fingerprint largely in a similar manner independent of the trait selected for, indicating that experimental evolution led to a general stress selection response at the metabolomic level. Integrative analyses across data sets showed little similarity when general correlations between selection effects at the level of the metabolome and gene expression were compared. This is likely due to the fact that the changes caused by these selection regimes were rather mild and/or that the dominating determinants for gene expression and metabolite levels were different. However, expression of a number of genes was correlated with the metabolite data. Many of the identified genes were general stress response genes that are down-regulated in response to selection for some of the stresses in this study. Overall, the results illustrate that selection markedly alters the metabolite profile and that the coupling between different levels of biological organization indeed is present though not very strong for stress selection at this level. The results highlight the extreme complexity of environmental stress adaptation and the difficulty of extrapolating and interpreting responses across levels of biological organization.