Polybrominated diphenyl ethers (PBDE) in serum: findings from a US cohort of consumers of sport-caught fish

Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in foams, fabrics and plastics, and are common contaminants of household air and dust and bioaccumulate in wildlife, and are detectable in human tissues and in fish and animal food products. In the Great Lakes Basin sport fish consumption has been demonstrated to be an important source of PCB and DDE exposure. PBDEs are present in the same sport fish but prior to our study the contribution to human PBDE body burdens from Great Lakes sport fish consumption had not been investigated. This study was designed to assess PBDE, PCB and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (DDE) serum concentrations in an existing cohort of 508 frequent and infrequent consumers of sport-caught fish living in five Great Lake states. BDE congeners 47 and 99 were identified in the majority of blood samples, 98% and 62% respectively. summation operatorPBDE levels were positively associated with age, hours spent outdoors, DDE, summation operatorPCB, years of sportfish consumption, and catfish and shellfish intake, and negatively associated with income and recent weight loss. Other dietary components collected were not predictive of measured summation operatorPBDE levels. In multivariate models, summation operatorPBDE levels were positively associated with age, years consuming sport fish, shellfish meals, and computer use and negatively associated with recent weight loss. Having summation operatorPBDE levels in the highest quintile was independently associated with older age, male gender, consumption of catfish and shellfish, computer use and spending less time indoors. summation operatorPCB and DDE were strongly associated suggesting common exposure routes. The association between summation operatorPBDE and summation operatorPCB or DDE was much weaker and modeling suggested more diverse PBDE sources with few identified multi-contaminant-shared exposure routes. In our cohort Great Lakes sport fish consumption does not contribute strongly to PBDE exposure.     

Partial stroke testing of process shutdown valves: How to determine the test coverage

Partial stroke testing (PST) has recently been introduced as a semi-automatic means to test process shutdown valves. Normally, this type of testing does not disturb the process and can detect many of the failures that traditionally have been revealed only by functional testing. The fraction of all dangerous failures that are detected by PST is called the PST coverage and is decisive for the effectiveness of the PST. So far, limited guidance on how to determine the PST coverage has been given. This paper discusses the application and limitations of PST and suggests a new procedure for how to determine the PST coverage factor.     

Dispositional and contextual determinants of organizational citizenship behavior

This study of 402 professional and administrative employees of a VA hospital addressed the question of whether certain dispositional factors (Agreeableness, Conscientiousness, and Equity Sensitivity) could account for the relationship between contextual work attitudes and organizational citizenship behavior (OCB). Findings indicate this not to be the case. Fairness/satisfaction had independent effects on OCB. Additionally, Conscientiousness predicted some forms of OCB. Neither Agreeableness nor Equity Sensitivity affected OCB. Implications are noted for further inquiry into OCB.     

Overview of particulate exposures in the US trucking industry

As part of a large epidemiologic study of lung cancer, 55,000 subjects, we have conducted a nation-wide survey of particulate exposures in the US trucking industry. The goal is to differentiate the risks from various types of particulate exposures, such as traffic emissions and general air pollution. We hypothesize that exposures defined by job and work site characteristics can be linked with subjects using their personal job histories. This report covers exposures at 36 randomly chosen large truck freight terminals in the US. Measurements were made of PM2.5, elemental carbon (EC), and organic carbon (OC) upwind of the terminal (background) and in work areas, and by personal samples. Significant differences in exposure intensity, microg m(-3), were found for work locations and jobs relative to background levels (GM[GSD]) at terminal sites: PM2.5 9.8[2.34], EC 0.5[3.24], and OC 5.0[1.76]. Using EC as a marker for diesel particles, work locations varied significantly: office 0.3[3.7], dock area 0.7[2.89] and shop area 1.5[3.52]), as did job titles (non-smokers): clerk 0.1[9.98], dock worker 0.8[2.13], and mechanic 2.0[3.82]. Cigarette smoking contributed substantially to personal exposures, approximately doubling PM2.5 and OC, but having less of an effect on EC. Large differences were seen across the terminal sites due to differences in local regional air pollution levels from traffic and other sources. We conclude that it will be possible to estimate current exposures of the cohort using an exposure assignment matrix based on job title, work location, and terminal site. This distribution overlaps substantially with the general public's exposure to these sources.     

Estimating the effects of urban residential development on water quality using microdata

In this study, we examine the impact on water quality of urbanization using disaggregate data from Wake County, North Carolina. We use a unique panel data set tracing the conversion of individual residentially zoned land parcels to relate the density of residential development and the change in residential land use to three measures of water quality. Using a spatial econometrics model, we relate spatially and temporally referenced monitoring station readings to our measures of residential land use while controlling for other factors affecting water quality. We find that both the density of residential land use and the rate of land conversion have a negative impact on water quality. The impacts of these non-point sources are found to be larger in magnitude than those from urban point sources.     

Storage and metabolism of radioactively labeled pyrrolizidine alkaloids by butterflies and larvae of Mechanitis polymnia (Lepidoptera: Nymphalidae,Ithomiinae)

Summary. Tracer feeding studies with radioactively labeled pyrrolizidine alkaloids (PAs) were performed to attain experimental information about the specificity and mechanisms of uptake, metabolism and storage of PAs in the alkaloid sequestering ithomiine butterfly Mechanitis polymnia. Adult butterflies easily ingest the tracers offered dissolved in a saturated sugar solution. Feeding of [¹⁴C]rinderine (free base) confirmed that M. polymnia is well adapted to sequester and maintain PAs of the lycopsamine type. Approximately 80% of the ingested radioactivity can be recovered in methanol extracts of the butterflies over a period of at least 6 hours. Labeled rinderine is efficiently N-oxidized and transformed into a metabolite of still unknown structure. These two metabolites are formed in almost equal amounts and account for more than 90% of total radioactivity. After four hours the toxic free base is only detectable in traces. Radioactively labeled senecioylretronecine (free base), a PA that often accompanies PAs of the lycopsamine type in plants, is metabolized in a different manner. The toxic free base disappeared as fast as the tertiary rinderine, but the final products which accumulated in a stable ratio after 12 hours were mainly two polar metabolites of unknown structure; senecioylretronecine N-oxide accounts for less than 10% of total PAs. Labeled senecionine a macrocyclic PA, which never has been found in wild caught M. polymnia is only slowly N-oxidized. In females ca 50% of the ingested senecionine is still present as free base after 24 hours, whereas under the same conditions in males this percentage is only ca 20%. This difference in N-oxidation was the only significant sex-specific difference observed in various experiments. Larvae of M. polymnia which feed on Solanum tabacifolium, a plant that does not contain PAs, are able to sequester and partly N-oxidize labeled senecioylretronecine and senecionine. However, the storage is not very efficient; with the two tracers less than 5% of radioactivity remained in the bodies after 24 hours. Received 19 October 1999; accepted 24 November 1999     

Agricultural Production Monitoring in the Sahel Using Remote Sensing: Present Possibilities and Research Needs

The main objective is to review the current status of research related to the monitoring of agricultural production in the Sahel (west Africa). The Sahel suffers from frequent shortages of food. It is therefore important to have a tool to monitor environmental variables, and thus crop production, during the agricultural season. Satellite remote sensing can contribute significantly to such a system by collecting information on crops and on environmental variables at a sub-continental geographical scale and with a high temporal frequency. One part of the problem is to estimate crop acreage. The technique of area-sampling frame has to adapted to the Sahelian landscape, which is dominated by traditional farming systems. The second part is to estimate crop yields. Three main approaches exist: statistical, semi-deterministic or deterministic. The use of vegetation indices is discussed as well as techniques to derive biophysical variables from remotely-sensed data. Finally, the integration of these remote-sensing techniques with crop-growth models is discussed and some research needs are identified. It is argued that the quantitative assessment of agricultural production in the Sahel should be based on the integration of remotely-sensed data with semi-deterministic agrometeorological models. This approach will allow a regionalization of the production estimates.