Abschätzung des umweltchemischen und ökotoxikologischen Verhaltens von Stoffen durch computergestützte Analyse von Struktur und Verhalten sowie von Struktur und Wirkung

Risk assessment of chemicals requires comprehensive data material, which often is not available. To provide substitutes for the lacking experimental ecotoxicological and physico-chemical data, a software-system (SAR-System) has been developed comprising more than 90 estimation models for relevant endpoints. The approach is based on quantitative structure-activity relationships (QSAR). Two major aspects characterize the SAR-System:

1. The implemented models were tested for their validity and application range.
2. The QSARs are accessible by a menu-driven programme package.

The following endpoints are included: Thysico-Chemical Data: 1-Octanol/water-partition-coefficient log P_ow, vapour pressure, water solubility, pK_a-value, boiling point Biological Data: Toxicity towards fish, daphnia, tetrahymenae, algae, bacteria and mammals, mutagenicity. Distribution: soil sorption, bioconcentration, Henry-Constant, Mackay (Level I). Degradation: photodegradation, biodegradability.     

Epidemiological studies on bicycle manufacturing industrial workers

Studies involving health status of bicycle manufacturing industrial workers exposed to chemicals and unexposed workers of the same industry who formed control were conducted at Sonepatin Haryana State, India. Negligence of industrial hygiene and personal protection affected the health of exposed workers adversely Epidemiological spectrum of exposed subjects showed much variation from control. Some unique disorders, such as nail impairments, nasal septum perforation and metal fume fever were observed in exposed workers against their absence in unexposed workers. Data showed occurrence of following diseases in the order of asthma>skin disorders>allergic disorders>bronchitis>all other respiratory diseases>nail disorders and acute pharyngitis>pulmonary tuberculosis and loss of smell and hearing>nasal septum perforation showing high risk factor for 'all other respiratory diseases' and skin disorders. Importance of occupational health surveillance has been highlighted.     

Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics

In order to assess potential risks of exposure to environmental chemicals, more information on concomitant exposure to different chemicals is needed. We present data on chemicals in human milk of a cohort study (2004, 2005, 2006) of 54 mother/child pairs, where for the first time, cosmetic UV filters, synthetic musks, parabens and phthalate metabolites were analyzed in the same sample along with persistent organochlor pollutants (POPs), i.e., organochlor pesticides and metabolites, polybrominated diphenylethers and polychlorinated biphenyls (PCBs). The two groups of chemicals exhibited different exposure patterns. Six out of seven PCB congeners and a majority of pesticides were present in all milk samples, with significant correlations between certain PCB congener and pesticide levels, whereas the cosmetic-derived compounds, UV filters, parabens and synthetic musks, exhibited a more variable exposure pattern with inter-individual differences. UV filters were present in 85.2% of milk samples, in the range of PCB levels. Comparison with a questionnaire revealed a significant correlation between use of products containing UV filters and their presence in milk for two frequently used and detected UV filters, 4-methylbenzylidene camphor and octocrylene, and for the whole group of UV filters. Concentrations of PCBs and organochlor pesticides were within ranges seen in Western and Southern European countries. For several POPs, mean and/or maximum daily intake calculated from individual concentrations was above recent US EPA reference dose values. Our data emphasize the need for analyses of complex mixtures to obtain more information on inter-individual and temporal variability of human exposure to different types of chemicals.     

Discourses of Place: Environmental Interpretation about Vermont Forests

Motivated by a lack of scholarly attention to the substance of interpretive messages and materials, this study examines discursive aspects of interpretative brochures available at forest recreation and tourism sites in Vermont, United States. Directive statements that instruct and guide visitor experiences—and the discourses to which they contribute—were analyzed for content, form, and meaning. Across the interpretive brochures, four broad discourses were identified: the natural forest, the recreational forest, the productive forest, and the dependent forest. Consideration of intertextuality revealed a fifth, hybrid discourse that linked forests to meanings of Vermont as a distinctive place. The convergence of these discourses across the set of brochures gives insight into the ways interpretation serves to both direct individual visitor experiences at particular sites, and to influence the development of larger-scale place meanings.     

Phenolic compounds in leaves of Salix species and hybrids growing under different soil conditions

The leaves of eight Salix species/hybrids were collected from two sites with different soil conditions including metal concentrations to investigate the concentration of Cu, Zn and Pb, phenolic profile and antioxidant scavenging activity. Cu, Zn and Pb, phenolic content and scavenging activity in leaves from the control area (lower concentration of metals in soil) (site C) were lower than in plants cultivated in site G (higher concentration of metals in soil). The content of Cu, Pb and Zn in leaves was in the range 9.21 (site G)–52.36 (site G), 0.41 (site C)?12.03 (site C) and 27.23 (site C)–214.44 (site G) mg?kg^?1, respectively. Total phenolic content ranged between 18.19 (site C) and 84.71 (site G) mg gallic acid equivalent per gram of dry matter. Total flavonoid content was between 7.98 (site C) and 54.48 (site G) mg catechin g^?1?d.m. The scavenging effect on 2,2-diphenyl-1-picrylhydrazyl˙ ranged between 33.6% (site C) and 56.3% (site G). Phenolic acids, myricetin and quercetin were quantified in leaves. The results show that phenolics are involved during adaptive mechanisms under elevated content of Cu, Pb and Zn in soil. Changes in the phenolic composition in leaves can be suggested as indicators of metal stress in Salix plants.     

A landscape vulnerability analysis method proposal and its integration in the EIA

Landscape is the area primarily affected by proposed human projects. The prediction and evaluation of the potential anthropogenic impacts under Environmental Impact Assessment (EIA) is therefore one of the major environmental tools for prevention of any deteriorative or destructive actions. To conduct EIA properly requires inclusion of a determination of landscape vulnerability which expresses the possible landscape reaction to impacts of any exogenous factors. When it is designated correctly, the suitable human activities are determined more accurately. Even though many techniques for this have been suggested worldwide, lots of deficiencies have surfaced in their application. This paper presents a method for landscape vulnerability analysis which consists of qualitative evaluation of landscape receptors, their scoring, the vulnerability degree calculation, and overall reliability evaluation. The method proposed can improve the impact objectivity of prediction and evaluation and the suggestion of precise mitigation measures with the purpose of achieving sustainable landscape management.     

Evaluation of potential genotoxic/cytotoxic effects induced by epoxiconazole and fenpropimorph-based fungicide in bovine lymphocytes in vitro

Potential genotoxic/cytotoxic effects of the epoxiconazole/fenpropimorph-based fungicide were investigated using single cell gel electrophoresis and cytogenetic assays: chromosomal aberrations, sister chromatid exchanges, micronuclei and fluorescence in situ hybridization in cultured bovine lymphocytes. No statistically significant elevations of DNA damage and increases in cytogenetic endpoints were seen. However, evident cytotoxic effect presented as a decrease in mitotic and proliferation indices were recorded after exposure of bovine lymphocytes to the fungicide for 24 and 48 h at concentrations ranging from 3 to 15 µg mL^?1 (P < 0.05, P < 0.01, P < 0.001). Similarly, for 24 h an inhibition in the cytokinesis block proliferation index (CBPI) was obtained after exposure to the fungicide at concentrations ranging from 1.5 to 15 µg mL^?1 (P < 0.01, P < 0.001) in each donor.     

Application of physicochemical data for water-quality assessment of watercourses in the Gdansk Municipality (South Baltic coast)

The paper presents water-quality evaluation based on an 8-year monitoring programme in the Gdansk Municipality region, on the Southern coast of the Baltic Sea. The studies were carried out from 2000 to 2007 by surface water analysis at 15 various sites within eight watercourses. Sampling sites included rather urbanized or developed lands, farming fields and non-polluted city recreational areas such as parks and forests. Most of the watercourses were sampled monthly at two locations, one within the upper course of the watercourse and the other near its mouth. In all samples, eight parameters of water quality were determined: total suspended solids, dissolved oxygen, water temperature, oxygen saturation, 5-day biochemical oxygen demand, chemical oxygen demand, total phosphorus and total nitrogen concentration. Interpretation of the obtained results revealed that examination of those basic physicochemical parameters permits to discriminate initially watercourses with respect to level of water contamination. During the research, a large dataset was obtained and it was described by both basic statistical parameters and chemometric method of cluster analysis. The paper presents relations between analysed parameters and influence of land exploitation mode on water quality and describes variation of the results both in space and time.     

Geographical location and key sensitivity issues of post-industrial regions in Europe

Primary objectives of our work were to spatially delineate post industrial areas of the EU-27 and indicate key environmental, social and economic sensitivity issues for these regions. The density of industrial sites within NUTS-x regions for EU-27 countries was assessed by using CORINE 2000 land cover layer. A development of postindustrial society in Europe represents a strong geographic diversity. There are distinct historical and current differences between regions which form major groups, comprising similar internal characteristics and definable trends in environmental and socioeconomic sense. Regions grouped into postindustrial clusters are fundamentally different from the European average, and are facing specific problems related to global market and political changes. Eastern postindustrial regions can be characterized as socially and economically weak, exhibiting high unemployment rate, low GDP, negative population growth and a strong environmental pressure, represented by a high density of dump sites. Most of the western EU postindustrial areas have been successfully recovered and moved into new economy as shown by most of the indicators. In urban postindustrial zones, however, emission sources of pollutants seem to continually be a major problem--not necessarily in terms of exceeding thresholds, but through a remarkable difference in the amount of pollutants produced relative to other regions.