Semilobar holoprosencephaly prenatal diagnosis: an unexpected complex rearrangement in a de novo apparently balanced reciprocal translocation on karyotype

We report a semilobar holoprosencephaly (HPE) in a post-intracytoplasmic-sperm-injection pregnancy. It was suggested by ultrasonography (US), documented on karyotype, identified with magnetic resonance imaging (MRI), established after birth and confirmed on post-mortem autopsy. An amniocentesis revealed a de novo apparently balanced reciprocal translocation 46,XY, t(7;8) (q31.3;q12). Fluorescence in situ hybridization (FISH) identified a deletion in the region of the Sonic Hedgehog gene (SHH) on der(8); nevertheless, the subtelomeric regions for chromosomes 7 and 8 were present. The parents decided to continue the pregnancy; a boy was born and survived for 3 days. The brain autopsy confirmed the semilobar HPE previously noted on US and MRI. Further, band-specific FISH revealed, in addition to SHH deletion, the presence of an inversion in the 7q translocated material on der(8). The parents' karyotypes were normal. An unexpected complex rearrangement was present in a de novo apparently balanced reciprocal translocation in a semilobar HPE. Copyright © 2007 John Wiley & Sons, Ltd.     

Female siskins choose mates by the size of the yellow wing stripe

Commonly, female birds use the brightly coloured patches on males to choose the best-quality mates. Coloured wing patches, however, have received little attention or have been previously related to social behaviour (as a signal to recruit conspecific individuals at feeding patches) or foraging (to flush prey) contexts, rather than to sexual selection. Here we provide evidence that in siskins (Carduelis spinus), wing patches function in mate choice. Mate-choice experiments showed that females were attracted by the size of the yellow wing stripe of the male, but not by the size of its black bib, body size, general plumage brightness or age. Experiments on birds with manipulated yellow wing stripes showed that females were sensitive to the size of this colour patch, irrespective of other male qualities. The preference of female siskins for males with larger wing patches when searching for a mate may be explained by the relationship of this trait to foraging ability, which would ensure females good parental investment from the chosen male.Communicated by W.A. Searcy     

A CFD study of wind patterns over a desert dune and the effect on seed dispersion

In the Namib Desert seed distribution is greatly influenced by wind patterns. Existing literature regarding wind patterns over dunes focuses on two-dimensional simulations of flow over simplified dune structures. The three-dimensional geometries of the sand dunes suggests far more complex flow features exist, which are not captured by two-dimensional simulations. Computational fluid dynamics (CFD) was used to reproduce the three-dimensional near surface wind patterns around a dune with the aim to learn more about seed distribution. Field work included terrain mapping, wind speed, direction and temperature metering. The CFD results show the expected two-dimensional flow features of high pressure at the dune toe, low pressure at the crest and flow acceleration up windward slope. Also observed are some three-dimensional flow features such as a spiral vortex near the crest and transverse flow due to crest-line curvature of the dune. It was also observed how the wall shear stress differs due to the three-dimensional shape of the dune. The wall shear stress suggests that seed accumulation is more likely to occur behind trailing (down-wind) crest edges. Particle tracking showed how seeds tend to move over the dune crest and recirculate towards the crest on the lee-side. The study showed that adding the third dimension makes the simulations more complex, adds to computational requirements and increases simulation time but also provides vital flow information which is not possible with two-dimensional simulations.