Rapid interphase analysis for prenatal diagnosis of translocation carriers using subtelomeric probes

Interphase fluorescence in situ hybridization (FISH) has become an accepted laboratory technique for the rapid and preliminary prenatal assessment of chromosome aneuploidy. The introduction of subtelomeric FISH probes now allows for the molecular–cytogenetic analysis of terminal chromosome rearrangements. In a prospective study, we examined the prenatal use of subtelomeric probes on interphase cells to rapidly detect the carrier status of a fetus when a parent carried a known reciprocal or Robertsonian chromosome translocation. Three of the cases were identified as being abnormal. All cases were confirmed by routine cytogenetic analysis. These findings clearly demonstrated the utility of this technique and these probes to rapidly and correctly identify balanced and unbalanced chromosome anomalies of a fetus that could result from parental translocations. Copyright © 2002 John Wiley & Sons, Ltd.     

Socio-economic Impacts of Local Environmental Policies: An analysis for the field of climate protection

Local environmental policies are sometimes seen as standing in the way of socio-economic progress. Against the background of these concerns, the actual socio-economic impacts of climate protection measures are discussed in this paper. It is structured as follows. First, the concept of primary and secondary effects of climate policies is introduced. Secondly, there is a discussion of financial and economic impacts of local climate policies. Finally, information is given on the consequences of such measures for local energy security and air quality. The main conclusion is that, at least in the field of climate policies, there is a huge potential for local measures that are socioeconomically attractive to local communities. HAUKE VON SEHT, Impactos socio-económicos de políticas del medio ambiente local, un análisis para el campo de protección climática . Las políticas ambientales locales son vistas algunas veces como si estuvieran en la via del progreso socio-económico. En contra de los antecedentes de estos asuntos, los impactos socio-económicos actuales de las medidas de protección climaticas son discutidos en este documento. Está extructurado de la siguiente manera: Primero serán introducidos el concepto de efectos primarios y secundarios de las políticas climáticas. Luego sigue una discusión de impactos económicos y financieros de las políticas climáticas locales, seguido por información de las consecuencias de tales medidas para la calidad del aire y seguridad de energía local. La conclusión principal es que por lo menos en el campo de las políticas climáticas hay un inmenso potencial de medidas locales que son socio-económicamente actractivas a las comunidades locales.     

Variability of tropospheric hydroperoxides at a coastal surface site in Antarctica

The annual cycles of hydrogen peroxide (H₂O₂) and methylhydroperoxide (MHP) have been investigated at a remote site in Antarctica in order to study seasonal variations as well as chemical processes in the troposphere. The measurements have been performed from March 1997 to January 1998 and in February 1999 at the German Antarctic research station Neumayer which is located at 70°39′S, 8°15′W. The obtained time series for hydrogen peroxide and methylhydroperoxide in near-surface air represents the first all-year measurements in Antarctica and indicates clearly the occurrence of seasonal variations. During polar night mean values of 0.054±0.046 ppbv (range<0.03–0.11 ppbv) for hydrogen peroxide and 0.089±0.052 ppbv (range<0.05–0.14 ppbv) for methylhydroperoxide were detected. At the sunlit period higher Mixing ratios were found, 0.20±0.13 ppbv (range<0.03–0.91 ppbv) for hydrogen peroxide and 0.19±0.10 ppbv (range<0.05–0.89 ppbv) for methylhydroperoxide. Occasional long-range transport of air masses from mid-latitudes caused enhanced peroxide concentrations at polar night. During the period of stratospheric ozone depletion we observed peroxide mixing ratios comparable to typical winter levels.     

Innovative process routes for a high-quality concrete recycling

This study presents alternative methods for the processing of concrete waste. The mechanical stresses needed for the embrittlement of the mortar matrix and further selective crushing of concrete were generated by either electric impulses or microwaves heating. Tests were carried out on lab-made concrete samples representative of concrete waste from concrete mixer trucks and on concrete waste collected on a French demolition site. The results obtained so far show that both techniques can be used to weaken concrete samples and to enhance aggregate selective liberation (that is the production of cement paste-free aggregates) during crushing and grinding. Electric pulses treatment seems to appear more efficient, more robust and less energy consuming (1–3 kW h t^?1) than microwave treatment (10–40 kW h t^?1) but it can only be applied on samples in water leading to a major drawback for recycling aggregates or cement paste in the cement production process.