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741.
Keeping the blood flowing—plasminogen activator genes and feeding behavior in vampire bats 总被引:1,自引:0,他引:1
Tellgren-Roth A Dittmar K Massey SE Kemi C Tellgren-Roth C Savolainen P Lyons LA Liberles DA 《Die Naturwissenschaften》2009,96(1):39-47
The blood feeding vampire bats emerged from New World leaf-nosed bats that fed on fruit and insects. Plasminogen activator,
a serine protease that regulates blood coagulation, is known to be expressed in the saliva of Desmodus rotundus (common vampire bat) and is thought to be a key enzyme for the emergence of blood feeding in vampire bats. To better understand
the evolution of this biological function, we studied the plasminogen activator (PA) genes from all vampire bat species in
light of their feeding transition to bird and subsequently mammalian blood. We include the rare species Diphylla ecaudata and Diaemus youngi, where plasminogen activator had not previously been studied and demonstrate that PA gene duplication observed in Desmodus is not essential to the vampire phenotype, but relates to the emergence of predominant mammalian blood feeding in this species.
Plasminogen activator has evolved through gene duplication, domain loss, and sequence evolution leading to change in fibrin-specificity
and susceptibility to plasminogen activator inhibitor-1. Before undertaking this study, only the four plasminogen activator
isoforms from Desmodus were known. The evolution of vampire bat plasminogen activators can now be linked phylogenetically to the transition in feeding
behavior among vampire bat species from bird to mammalian blood.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
742.
743.
Mann RE Stoduto G Butters J Ialomiteanu A Boase P Asbridge M Chipman M Wickens CM 《Journal of Safety Research》2010,41(5):445-449
Introduction
The purpose of the current study was to examine differences in factors associated with self-reported collision involvement of three age groups of drivers based on a large representative sample of Ontario adults. Method: This study was based on data from the CAMH Monitor, an ongoing cross-sectional telephone survey of Ontario adults 18 years and older from 2002 to 2005. Three age groups were examined: 18-34 (n = 1,294), 35-54 (n = 2,428), and 55+ (n = 1,576). For each age group sample, a logistic regression analysis was conducted of self-reported collision involvement in the last 12 months by risk factor measures of driving exposure (kilometers driven in a typical week, driving is stressful, and driving on busy roads), consuming five or more drinks of alcohol on one occasion (past 12 months), cannabis use (lifetime, and past 12 months), and driving after drinking among drinkers (past 12 months), controlling for demographics (gender, region, income, and marital status). Results: The study identified differences in factors associated with self-reported collision involvement of the three age groups of adult drivers. The logistic regression model for the youngest group revealed that drivers who reported that driving was stressful at least some of the time, drank five or more drinks on an occasion, and drove after drinking had an increased risk of collision involvement. For the middle age group, those who reported using cannabis in the last 12 months had significantly increased odds of reporting collision involvement. None of the risk factor measures showed significant associations with collision risk for older drivers (aged 55+). Impact: The results suggest potential areas for intervention and new directions for future research. 相似文献744.
Kines P Andersen LP Spangenberg S Mikkelsen KL Dyreborg J Zohar D 《Journal of Safety Research》2010,41(5):399-406
Background
The construction industry is one of the most injury-prone industries, in which production is usually prioritized over safety in daily on-site communication. Workers have an informal and oral culture of risk, in which safety is rarely openly expressed. This paper tests the effect of increasing leader-based on-site verbal safety communication on the level of safety and safety climate at construction sites. Method: A pre-post intervention-control design with five construction work gangs is carried out. Foremen in two intervention groups are coached and given bi-weekly feedback about their daily verbal safety communications with their workers. Foremen-worker verbal safety exchanges (experience sampling method, n = 1,693 interviews), construction site safety level (correct vs. incorrect, n = 22,077 single observations), and safety climate (seven dimensions, n = 105 questionnaires) are measured over a period of up to 42 weeks. Results: Baseline measurements in the two intervention and three control groups reveal that foremen speak with their workers several times a day. Workers perceive safety as part of their verbal communication with their foremen in only 6-16% of exchanges, and the levels of safety at the sites range from 70-87% (correct observations). Measurements from baseline to follow-up in the two intervention groups reveal that safety communication between foremen and workers increases significantly in one of the groups (factor 7.1 increase), and a significant yet smaller increase is found when the two intervention groups are combined (factor 4.6). Significant increases in the level of safety are seen in both intervention groups (7% and 12% increases, respectively), particularly in regards to 'access ways' and 'railings and coverings' (39% and 84% increases, respectively). Increases in safety climate are seen in only one of the intervention groups with respect to their 'attention to safety.' No significant trend changes are seen in the three control groups on any of the three measures. Conclusions: Coaching construction site foremen to include safety in their daily verbal exchanges with workers has a significantly positive and lasting effect on the level of safety, which is a proximal estimate for work-related accidents. It is recommended that future studies include coaching and feedback at all organizational levels and for all involved parties in the construction process. Building client regulations could assign the task of coaching to the client appointed safety coordinators or a manager/supervisor, and studies should measure longitudinal effects of coaching by following foremen and their work gangs from site to site. 相似文献745.
Bytnerowicz A Godzik B Grodzińska K Fraczek W Musselman R Manning W Badea O Popescu F Fleischer P 《Environmental pollution (Barking, Essex : 1987)》2004,130(1):5-16
Ambient ozone (O(3)) concentrations in the forested areas of the Central and Eastern European (CEE) mountains measured on passive sampler networks and in several locations equipped with active monitors are reviewed. Some areas of the Carpathian Mountains, especially in Romania and parts of Poland, as well as the Sumava and Brdy Mountains in the Czech Republic are characterized by low European background concentrations of the pollutant (summer season means approximately 30 ppb). Other parts of the Carpathians, especially the western part of the range (Slovakia, the Czech Republic and Poland), some of the Eastern (Ukraine) and Southern (Romania) Carpathians and the Jizerske Mountains have high O(3) levels with peak values >100 ppb and seasonal means approximately 50 ppb. Large portions of the CEE mountain forests experience O(3) exposures that are above levels recommended for protection of forest and natural vegetation. Continuation of monitoring efforts with a combination of active monitors and passive samplers is needed for developing risk assessment scenarios for forests and other natural areas of the CEE Region. 相似文献
746.
建立了描述填埋城市固体废弃物降解过程和行为的2阶段厌氧降解机理模型.模型考虑了含水率、挥发性脂肪酸(VFA)和pH值等主要环境因素的作用.为了适用于不同渗滤液酸化水平下的降解,单独考虑了pH值和分子态VFA对甲烷菌繁殖的影响.建立了气相高CO2分压下的渗滤液pH值计算方程,并给出了降解环境中CO2分压的计算方法.通过对一固废降解试验的模拟验证了模型的有效性.最后,采用所建立的pH值计算方程揭示了填埋环境下高CO2分压对渗滤液pH值影响显著,渗滤液pH值与VFA间缺乏不同酸化水平下的一致对应关系和高酸化水平下pH值对VFA浓度变化不敏感、分子态VFA抑制作用明显等规律. 相似文献
747.
Shufang WU Pute WU Hao FENG G. P. Merkley 《Frontiers of Environmental Science & Engineering》2011,5(1):76-83
An evaluation of the interactions between vegetation, overland and soil erosion can provide valuable insight for the conservation of soil and water. An experiment was conducted to study water infiltration, runoff generation process, rate of sediment erosion, and hydrodynamic characteristics of overland flow from a sloping hillside with different draw-off discharges from alfalfa and control plots with 20° slope. The effect of alfalfa on runoff and sediment transport reduction was quantitatively analyzed. Alfalfa was discussed for its ability to reduce the overland flow scouring force or change the runoff movement. Compared to the bare-soil plots, alfalfa plots generated a 1.77 times increase in infiltration rate. Furthermore, the down-slope water infiltration rate for the bare soil plots was higher than in the up-slope, while the opposite was found in the alfalfa plots. In addition, alfalfa had a significant effect on runoff and sediment yield. In comparison to the control, the runoff coefficient and sediment transportation rate decreased by 28.3% and 78.4% in the grass slope, respectively. The runoff generated from the alfalfa and bare-soil plots had similar trends with an initial increase and subsequent leveling to a steady-state rate. The transport of sediment reduced with time as a consequence of the depletion of loose surface materials. The maximum sediment concentration was recorded within the first few minutes of each event. The alfalfa plots had subcritical flow while the bare-soil plots had supercritical flow, which indicate that the capability of the alfalfa slope for resisting soil erosion and sediment movement was greater than for bare soil plots. Moreover, the flow resistance coefficient and roughness coefficient for the alfalfa plots were both higher than for the bare-soil plots, which indicate that overland flow in alfalfa plots had retarded and was blocked, and the flow energy along the runoff path had gradually dissipated. Finally, the ability to erode and transport sediment had decreased. 相似文献
748.
Effect of weathering on abundance and release of potentially toxic elements in soils developed on Lower Cambrian black shales, P. R. China 总被引:3,自引:0,他引:3
This paper examines the geochemical features of 8 soil profiles developed on metalliferous black shales distributed in the
central parts of the South China black shale horizon. The concentrations of 21 trace elements and 8 major elements were determined
using ICP-MS and XRF, respectively, and weathering intensity (W) was calculated according to a new technique recently proposed in the literature. The data showed that the black shale soils
inherited a heterogeneous geochemical character from their parent materials. A partial least square regression model and EFbedrock (enrichment factor normalized to underlying bedrock) indicated that W was not a major control in the redistribution of trace metals. Barium, Sn, Cu, V, and U tended to be leached in the upper
soil horizons and trapped by Al and Fe oxides, whereas Sb, Cd, and Mo with negative EF values across the whole profiles may
have been leached out during the first stage of pedogenesis (mainly weathering of black shale). Compared with the Chinese
average soils, the soils were strongly enriched in the potentially toxic metals Mo, Cd, Sb, Sn, U, V, Cu, and Ba, among which
the 5 first listed were enriched to the highest degrees. Elevated concentrations of these toxic metals can have a long-term
negative effect on human health, in particular, the soils in mining areas dominated by strongly acidic conditions. As a whole,
the black shale soils have much in common with acid sulfate soils. Therefore, black shale soils together with acid sulfate
soils deserve more attention in the context of metal exposure and human health. 相似文献
749.
Cadmium distribution in rice plants grown in three different soils after application of pig manure with added cadmium 总被引:2,自引:0,他引:2
Han C Wu L Tan W Zhong D Huang Y Luo Y Christie P 《Environmental geochemistry and health》2012,34(4):481-492
A glasshouse pot experiment was conducted to investigate Cd concentrations in the aboveground parts of two consecutive crops of rice and Cd availability in three different soils (loam, silt loam, and sandy loam) after application of pig manure with added Cd. Soil pH tended to increase with increasing application rate of pig manure from 1 to 3% (w/w, oven dry basis). Soil diethylene triamine pentaacetic acid (DTPA) extractable Cd showed a clear positive correlation with soil total Cd content and increased with increasing Cd amendment of the manure but showed no difference between the two manure application rates. Cd concentrations in the grain, husk, and straw were significantly and positively correlated with soil DTPA-extractable Cd (p < 0.001). Within each level of manure Cd, the higher rate (3%) of manure produced lower Cd concentrations in the grain, husk, and straw on all three soils than did the lower rate (1%) after the first crop, but this no longer occurred after the growth of the second crop. Grain Cd concentrations exceeded the Chinese National Food Quality Standard (0.2 mg kg(-1)) most often on the loam, with intermediate frequency on the silt loam, and least often on the sandy loam, the soil with the highest pH and lowest organic carbon content and cation exchange capacity. 相似文献
750.
Maity JP Nath B Kar S Chen CY Banerjee S Jean JS Liu MY Centeno JA Bhattacharya P Chang CL Santra SC 《Environmental geochemistry and health》2012,34(5):563-574
Drinking of arsenic (As)-contaminated groundwater has adverse effects on health of millions of people worldwide. This study aimed to determine the degree of severity of As exposure from drinking water in peri-urban Moyna and Ardebok villages, West Bengal, India. Arsenic concentrations in hair, nail and urine samp les of the individuals were determined. Arsenical dermatosis, keratosis and melanosis were investigated through medical evaluation. We have evaluated the association between As exposure from drinking water, and keratosis and melanosis outcomes. The results showed that 82.7?% of the sampled tube wells contain As concentrations above 10?μg/L, while 57.7?% contain As concentrations above 50?μg/L. The hair, nail and urine As concentrations were positively correlated with As concentrations in drinking water. In our study population, we observed a strong association between As concentrations ranging 51-99?μg/L and keratosis and melanosis outcomes, although the probability decreases at higher concentration ranges perhaps due to switching away from the use of As-contaminated tube wells for drinking and cooking purposes. High As concentrations in hair, nail and urine were observed to be associated with the age of the study population. The level of As concentrations in hair, nail and urine samples of the study population indicated the degree of severity of As exposure in the study region. 相似文献