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451.
Michael R. Elliott Patricia F. Waller Trivellore E. Raghunathan Jean T. Shope Roderick J. A. Little 《Journal of Safety Research》2000,31(4):229-242
This analysis examines the ability of previous offenses to predict future high-risk offenses, and similarly, the ability of crashes to predict future high-risk crashes, using the complete driver history data (up to 9 years) for a set of young Michigan subjects. As expected, those with previous ticketed offenses or reported crashes are at greater risk for future offenses or crashes; with a previous-year serious offense doubling the odds of serious offenses during the subsequent year, and a previous-year at-fault crash increasing the odds of subsequent-year at-fault crashes by nearly 50%. There is modest evidence that serious offenses and at-fault crashes may better predict subsequent behavior in females and in more experienced drivers. This latter finding is also evidenced by the fact that records of these young drivers are less predictive of subsequent driving history than is true for records of all drivers in general found in other studies. This suggests that, in the early stages of driving, offenses and crashes are, at least in part, attributable to inexperience, and hence, characteristic of all beginning drivers. 相似文献
452.
Jörg Römbke Hella Hempel Adam Scheffczyk Hans Schallnass Michel Alvinerie Jean -Pierre Lumaret Jan Koschorrek 《Environmental Sciences Europe》2007,19(3):197-205
Goal, Scope, and Background
According to European legislation, an environmental risk assessment of veterinary pharmaceuticals for dung beetles is required if the substance is a parasiticide for the treatment of pasture animals. However, the demonstration of the environmental safety of those substances for dung beetles is strongly hampered by the fact that no standardized test system is available so far. Therefore, starting with recommendations from the SETAC advisory group DOTTS (Dung Organism Toxicity Test Standardization), a test system using the widespread temperate dung beetle species Aphodius constans was developed.Methods
Using experiences gained at the University of Montpellier (e.g. in field studies) and in other terrestrial tests, details of culturing and testing of A. constans were investigated in a project sponsored by the German Environment Protection Agency (UBA). Basically, the survival of young larvae of A. constans exposed to the test substance spiked into formulated (i.e. dried, grounded and re-wetted) or fresh dung is measured over a period of three weeks. Using the model substance dimethoate (an insecticide required as positive control in tests with the predatory mite Hypoaspis aculeifer) the suitability of the new test was checked. Afterwards, the new test method was used to determine the toxicity of four common veterinary pharmaceuticals (ivermectin, dicyclanil, moxidectin, praziquantel) in formulated and fresh dung. Finally, the effects of ivermectin on the dung beetles were determined in a test using fresh dung from treated cattle.Results and Conclusions
For Dmethoate LC50-values were found in a range of 1–3 mg a.s./kg dung (dew.), depending on the dung type. Praziquantel did not show eirecis in the tested concentration range (i.e. up to 1000 mg a.s./kg Dung (DW). The LC50-values of the other three pharmaceuticals were very low (<6 mg a.s./kg dung (DW)). With the exception of Dicyclanil no differences between formulated and fresh dung were identified. In the case of ivermectin the LC50-value were even lower: about 0.5 mg a.s./kg dung (DW). No differences between the results of test in which the substance was spiked into dung and those tests which were performed with dung from treated cattle were found. These results prove the sensitivity as well as the robustness of this test method.Recommendations and Perspectives
Based on the experiences reported here, it is recommended to standardize this test in an international ring test so that it can be incorporated in the risk assessment process for veterinary pharmaceuticals as described in the currently developed international registration guidelines. 相似文献453.
Since the air pollution as measured by stationary monitoring stations is a poor indicator of the population exposure, personal monitors are indispensible to health effects studies. This article reviews the current research on the development of personal monitors. Although most of the analytical methods reviewed in this study appear to be sensitive to the levels of the target pollutants NO2, SO2, and O3 generally encountered in indoor and outdoor air, they lack the desired performance characteristics for a personal monitoring device, such as user safety and ease of operation, weight, and maintenance. Electrochemical transducers/sensors, which have not yet been exploited, are attractive candidates for the application to personal monitoring. This technique has an added feature of generating real-time measurements. A few research models and commercially attractive devices that can be used in field studies are included. 相似文献
454.
Paul E. Spector Cary L. Cooper Juan I. Sanchez Michael O'Driscoll Kate Sparks Peggy Bernin Andre Büssing Phil Dewe Peter Hart Luo Lu Karen Miller Lucio Flavio Renault de Moraes Gabrielle M. Ostrognay Milan Pagon Horea Pitariu Steven Poelmans Phani Radhakrishnan Vesselina Russinova Vladimir Salamatov Jesus Salgado Satoru Shima Oi Ling Siu Jean Benjamin Stora Mare Teichmann Tres Theorell Peter Vlerick Mina Westman Maria Widerszal‐Bazyl Paul Wong Shanfa Yu 《组织行为杂志》2001,22(8):815-832
Data were collected from managers in 24 nations/territories on work locus of control (LOC), individualism–collectivism (I–C), and well‐being (job satisfaction, absence of psychological strain, and absence of physical strain). There were significant mean differences across samples on all five of these measures, and consistent with our hypothesis, at the ecological or sample mean level well‐being was associated with an internal locus of control. However, contrary to our hypothesis, well‐being was not associated with I–C, despite a strong correlation between I–C and LOC. Findings at the ecological level were consistent with the literature concerning the salutary effects of control on well‐being. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
455.
456.
Sabine Grootenboer-Mignot Aurore Crétien Ingrid Laurendeau Marie-Hélène Poissonnier Valérie Doireau Yves Brossard Gil Tchernia Thérèse Cynober Jean Delaunay 《黑龙江环境通报》2003,23(5):380-384
Dehydrated hereditary stomatocytosis (DHS) is a rare congenital hemolytic anemia mapping to 16q23–q24. We showed recently that it is part of a pleiotropic syndrome likely to display pseudohyperkalemia and/or different forms of fetal and placental fluid collections. Here, we report a woman with DHS. She had two consecutive pregnancies associated with severe fetal hydrops. Hydrops would probably have been lethal in the absence of appropriate removal of ascites and excess amniotic fluid. In utero exchange transfusion, performed once, was useless, because anemia was not pronounced enough to be the cause of the hydrops. In both newborns, ascites resolved within a week following birth and never recurred. The association of hydrops and hemolytic anemia suggests the possibility of DHS. Symptomatic treatment of the hydrops assists survival until spontaneous resorption occurs. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
457.
Abstract: The influence of landscape matrix on functional connectivity has been clearly established. Now methods to assess the effects of different land uses on species’ movements are needed because current methods are often biased. The use of physiological parameters as indicators of the level of resistance to animal movement associated with different land uses (i.e., matrix resistance) could provide estimates of energetic costs and risks to animals migrating through the matrix. To assess whether corticosterone levels indicate matrix resistance, we conducted experiments on substrate choice and measured levels of corticosterone before and after exposure of toads (Bufo bufo) to 3 common substrates (ploughed soil, meadow, and forest litter). We expected matrix resistance and hormone levels to increase from forest litter (habitat of the toad) to meadows to ploughed soil. Adult toads had higher corticosterone levels on ploughed soil than on forest litter or meadow substrates. Hormone levels did not differ between forest litter and meadow. Toads avoided moving onto ploughed soil. Corticosterone levels in juvenile toads were not related to substrate type; however, hormone levels decreased as humidity increased. Juveniles, unlike adults, did not avoid moving over ploughed soil. The difference in responses between adult and juvenile toads may have been due to differences in experimental design (for juveniles, entire body used to measure corticosterone concentration; for adults, saliva alone); differences in the scale of sensory perception of the substrate (juveniles are much smaller than adults); or differences in cognitive processes between adult and juvenile toads. Adults probably had experience with different substrate types, whereas juveniles first emerging from the water probably did not. As a consequence, arable lands could act as ecological traps for juvenile toads. 相似文献
458.
Gilles Morin Jean Gekas Philippe Naepels Jean Gondry Bernard Devauchelle Sylvie Testelin Henri Sevestre François Thépôt Michèle Mathieu 《黑龙江环境通报》2001,21(10):890-893
Ultrasonography in a female fetus revealed cystic cervical hygroma, severe micrognathia, and vertebral and upper limb anomalies suggestive of cerebro-costo-mandibular syndrome (CCMS) which was diagnosed ultrasonographically at 16 weeks' gestation. The father is affected and presents with a Pierre Robin sequence, short stature and typical costovertebral anomalies. CCMS is a rare and severe disorder. The high frequency of sporadic cases, vertical transmission, and the excess of sibs affected via horizontal transmission suggest dominant autosomal mutation with possible germinal mosaicism. The vertical familial case detailed in the present report is a reminder of the high risk when one parent or one sibling is affected and the extreme variability of phenotype and costal ossification. Early prenatal ultrasound diagnosis is possible in a severely affected fetus. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
459.
Catherine Buhé Gilbert Achard Jean François Le Téno Jean Luc Chevalier 《Resources, Conservation and Recycling》1997,20(4):227-243
The life cycle analysis of a product enables one to assess its environmental quality. A simple, transparent method taking into account the processes of recycling in the life cycle is developed here. It permits dealing with all types of open loops of all sectors. The principles on which the proposed method is grounded are discussed. 相似文献
460.
Christ De Rooij Jean Charles Boutonnet Veronique Garny Andre Lecloux Roger Papp Roy S Thompson Dolf Van Wijk 《Environmental monitoring and assessment》1998,53(3):489-508
This risk assessment on tetrachloroethylene (PER) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 18 studies for fish, 13 studies for invertebrates and 8 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 51 µg/l. Most of the available monitoring data apply to rivers and estuary waters and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.2 µg PER/l water and a worst case PEC of 2.5 µg PER/l water. The calculated PEC/PNEC ratios give a safety margin of 20 to 250 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation. 相似文献