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Vancomycin-resistant enterococci (VRE) and methicillin-resistant staphylococci, most notably methicillin-resistant Staphylococcus aureus (MRSA), are serious clinical problems. The antibiotic arsenal available against them is limited, and new mutants worsen the
situation. We studied the activity of (+)-usnic acid, an old lichen-derived drug, and its sodium salt against clinical isolates
of VRE and MRSA using the agar diffusion and minimal inhibitory concentration (MIC) methods. The acid and, especially, the
sodium salt had potent antimicrobial activity against all clinical isolates of VRE and MRSA studied. The MIC values of the
sodium salt against VRE strains ranged between 4 and 16 μg/ml (1-day test) and between 4 and 31 μg/ml (2-day test), being
below 8 μg/ml for most strains. The salt had potent activity even against those strains that were not inhibited by ampicillin
(125 μg/ml), and it never lost its activity after 24 h, in contrast to ampicillin. Thus, in spite of the fact that usnic acid
can in some cases cause serious toxicity, it and its salts may be worth considering in clinical practice in cases where other
therapies have failed or the microbe is resistant toward other agents. 相似文献