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A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting 总被引:1,自引:0,他引:1
Peters JL Sutton AJ Jones DR Rushton L Abrams KR 《Journal of environmental science and health. Part. B》2006,41(7):1245-1258
To maximize the findings of animal experiments to inform likely health effects in humans, a thorough review and evaluation of the animal evidence is required. Systematic reviews and, where appropriate, meta-analyses have great potential in facilitating such an evaluation, making efficient use of the animal evidence while minimizing possible sources of bias. The extent to which systematic review and meta-analysis methods have been applied to evaluate animal experiments to inform human health is unknown. Using systematic review methods, we examine the extent and quality of systematic reviews and meta-analyses of in vivo animal experiments carried out to inform human health. We identified 103 articles meeting the inclusion criteria: 57 reported a systematic review, 29 a systematic review and a meta-analysis, and 17 reported a meta-analysis only. The use of these methods to evaluate animal evidence has increased over time. Although the reporting of systematic reviews is of adequate quality, the reporting of meta-analyses is poor. The inadequate reporting of meta-analyses observed here leads to questions on whether the most appropriate methods were used to maximize the use of the animal evidence to inform policy or decision-making. We recommend that guidelines proposed here be used to help improve the reporting of systematic reviews and meta-analyses of animal experiments. Further consideration of the use and methodological quality and reporting of such studies is needed. 相似文献
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Courtship displays and paternal care in male birds are generally thought to be mutually exclusive, because testosterone, necessary for stimulation of sexual behaviours, suppresses paternal behaviours. Superb fairy-wrens, Malurus cyaneus, are unusual in that males concurrently engage in courtship and paternal care. Fairy-wrens live in stable socially monogamous pairs with 0-4 subordinate male helpers. Both helper and dominant males provide care whenever it is required but continue courtship throughout the period of care as most fertilisations are extra-group and females are multi-brooded. To examine the role of testosterone in this trade-off, we compared testosterone levels in males of different social status, while they had dependent nestlings, and determined the effect of testosterone treatment on provisioning rates of pairs. Testosterone levels were lower in subordinate helpers, although these do not provide more paternal care than dominant males. Conversely, testosterone levels were similar in dominant males with or without helpers, although as the number of helpers increases males invest substantially less in nestling care and more in extra-group courtship. Although testosterone levels are high, irrespective of paternal duties, experimental testosterone treatment of males resulted in a large (65%) reduction in nestling feeding rates. Surprisingly, there was no indication that females compensated for this reduction in provisioning, suggesting that females might assume a constant male contribution to offspring care. We conclude that during nestling provisioning, male fairy-wrens maintain testosterone at an individual level that does not interfere with parental duties, while allowing high investment in extra-group courtship. 相似文献
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Kaspar Delhey Anne Peters Arild Johnsen Bart Kempenaers 《Behavioral ecology and sociobiology》2007,61(6):853-862
Sex-allocation theory predicts that females paired to attractive males should bias the brood sex ratio towards male offspring,
as these would inherit the attractiveness of their father. We studied sex allocation based on male ornamentation in blue tits.
Brood sex ratios varied with male UV coloration in an age-dependent manner. For juvenile males, the proportion of sons increased
with increasing UV ornamentation, which is in agreement with previous findings from a Swedish population. However, the relationship
between UV ornamentation and brood sex ratio was reversed for adult males, with females paired to less UV-ornamented adult
males producing more sons. This pattern fits with the observation that, in our population, less UV-ornamented adult males
sire the majority of extra-pair young. To test the causality of the association between brood sex ratio and male coloration,
we experimentally manipulated crown colour largely within the natural range. We created two groups of males: one with higher
and one with lower UV reflectance, UV(+) and UV(−), respectively. Contrary to our expectations, there was no significant treatment
effect. However, in UV(−), but not UV(+) males, the proportion of sons was negatively correlated with male coloration before
manipulation. This suggests that the UV(−) treatment caused males that were more UV ornamented to decline more in attractiveness,
as shown in a similar experiment in Sweden. However, given that correlational patterns differ between these populations, similarities
in experimental results should not be taken as evidence for consistent patterns of adaptive sex allocation in this species. 相似文献
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L.L. Lamparski T.J. Nestrick N.N. Frawley R.A. Hummel C.W. Kocher N.H. Mahle J.W. McCoy D.L. Miller T.L. Peters J.L. Pillepich W.E. Smith S.W. Tobey 《Chemosphere》1986,15(9-12):1445-1452
During 1983 and 1984, The Dow Chemical Company conducted a study to determine the extent of dioxin contamination at its Midland, Michigan plant and the surrounding area. The primary objectives of this study were to identify, rank order, and when possible quantify potential sources of dioxins to the environment and also to determine the extent of contamination in areas affected by the Dow facility. Early in the study, it was estimated that approximately 0.6g/year of 2378-TCDD was being emitted in 2.5 × 1010L of wastewater effluent. Data will describe observed sources of TCDD (both current and historical), environmental levels, existing water treatment methods, control measures taken, and future improvements on the water system to reduce TCDD in the effluent. 相似文献