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Estienney Marie Daval-Frerot Philippe Aho-Glélé Ludwig-Serge Piroth Lionel Stabile Pascal Gerbet Jean-Yves Rouleau Romain de Rougemont Alexis Belliot Gaël 《Food and environmental virology》2022,14(2):217-221
Food and Environmental Virology - Disinfection of hospital facilities and ambulances is an important issue for breaking the chain of transmission of viral pathogens. Hydrogen peroxide has provided... 相似文献
155.
In the present study, we demonstrate an integrated modeling approach for predicting internal tissue concentrations of chemicals
by coupling a multimedia environmental model and a generic physiologically based pharmacokinetic (PBPK) model. A case study
was designed for a region situated on the Seine river watershed, downstream of the Paris megacity, and for benzo(a)pyrene
emitted from industrial zones in the region. In this case study, these two models are linked only by water intake from riverine
system for the multimedia model into human body for the PBPK model. The limited monitoring data sets of B(a)P concentrations
in bottom sediment and in raw river water, obtained at the downstream of Paris, were used to re-construct long-term daily
concentrations of B(a)P in river water. The re-construction of long-term series of B(a)P level played a key role for the intermediate
model calibration (conducted in multimedia model) and thus for improving model input to PBPK model. In order to take into
account the parametric uncertainty in the model inputs, some input parameters relevant for the multimedia model were given
by probability density functions (PDFs); some generic PDFs were updated with site-specific measurements by a Bayesian approach.
The results of this study showed that the multimedia model fits well with actual annual measurements in sediments over one
decade. No accumulation of B(a)P in the organs was observed. In conclusion, this case study demonstrated the feasibility of
a full-chain assessment combining multimedia environmental predictions and PBPK modeling, including uncertainty and sensitivity
analyses. 相似文献
156.
Stéphane Bernard Loïc Youinou Philippe Gillard 《Journal of Loss Prevention in the Process Industries》2013,26(6):1493-1500
Pulverized materials such as metallic or polymer powders play a considerable role in many industrial processes. Their use requires the introduction of preventive safeguards to control the plant's safety.PA12 polymer powder processing by laser sintering is characteristic of this tendency. The present work concerns PA12 powder (bimodal particle size distribution: 10 μm and 55 μm) and relates to explosion sensitivity and the thermal degradation of this powder, which can occur during laser sintering. Minimum Ignition Energy is determined using a modified Hartmann tube combined with the Langlie method developed in the PRISME Laboratory. This study shows the influence of parameters such as distance between the electrodes, powder concentration and arc power on MIE values. Theses parameters vary in the range of 3–6 A for the current intensity of the spark and the electrode gap in the range of 2.5–4 mm. The MIE is obtained for a spark gap of 3 mm and current intensity of the 4 A spark in our device. It shows that the MIE is less than 40 mJ for concentrations approaching 1000 g/m3. At lower concentrations (under 150 g/m3) the MIE increases but discrepancies in measurements appear, probably because of the static electricity that creates strong irregularities in dust dispersion. The second part of this study concerns the thermal degradation of the PA12 which is performed by thermogravimetric experiments coupled with mass spectrometric (MS) analysis for gas investigation. The mass loss measurement combined with the gas analysis allows the principal stages of degradation to be determined so as to calculate the kinetics parameter PA12. Experiments have been performed for different heating rates between 1 and 30 K min?1 and the reproducibility of experiments has been verified. The activation energy is determined using two methods: Freidman and KAS. For a reaction rate of between 0.2 and 0.6, the activation energy is nearly constant. The KAS method gives a value of Ea = 250 kJ mol?1 and the Friedman method gives Ea = 300 kJ mol?1. The gas analysis by MS shows that oxidation begins at over 350 °C and finishes at under 650 °C with the formation of CO2 and H2O. Other major peaks with an m/z ratio of 29, 28 and 30 are noticed in this range of temperature. They show the presence of intermediate species such as C2H6, NO or CH2O. The presence of HCN is also detected (m/z ratio of 27). 相似文献
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Assessment of the contribution of land use pattern and intensity to landscape quality: use of a landscape indicator 总被引:4,自引:0,他引:4
The objective of this research work is the evaluation of the impact of landuse pattern and intensity on landscape by means of an indicator. The method used to calculate a ‘landscape indicator’ (Iland) allows to take into account the objective as well as the subjective approach of landscape. Iland corresponds to the degree of agreement between landscape supply by farmers and landscape demand by the social groups. The supply and the demand are evaluated through four criteria: ‘diversity’, ‘upkeep’, ‘openness’ and ‘heritage’. The landscape supply is calculated from data of landscape objects (punctual, linear and spatial) for each criterion recorded at the field level. The values of the four criteria for the landscape demand are allocated by the user(s) of the indicator (decision makers, regional council, social groups…) into five classes (0–4). The value of the landscape indicator is the least favourable difference between supply and demand for the four criteria. An example of calculation of the ‘landscape indicator’ for an arable farm is given. The collection of data needs 2 h with the farmer and 2 h for a survey of the farm land. 相似文献
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