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91.
Accounting for rate instability and spatial patterns in the boundary analysis of cancer mortality maps 总被引:1,自引:0,他引:1
Pierre Goovaerts 《Environmental and Ecological Statistics》2008,15(4):421-446
Boundary analysis of cancer maps may highlight areas where causative exposures change through geographic space, the presence
of local populations with distinct cancer incidences, or the impact of different cancer control methods. Too often, such analysis
ignores the spatial pattern of incidence or mortality rates and overlooks the fact that rates computed from sparsely populated
geographic entities can be very unreliable. This paper proposes a new methodology that accounts for the uncertainty and spatial
correlation of rate data in the detection of significant edges between adjacent entities or polygons. Poisson kriging is first
used to estimate the risk value and the associated standard error within each polygon, accounting for the population size
and the risk semivariogram computed from raw rates. The boundary statistic is then defined as half the absolute difference
between kriged risks. Its reference distribution, under the null hypothesis of no boundary, is derived through the generation
of multiple realizations of the spatial distribution of cancer risk values. This paper presents three types of neutral models
generated using methods of increasing complexity: the common random shuffle of estimated risk values, a spatial re-ordering
of these risks, or p-field simulation that accounts for the population size within each polygon. The approach is illustrated
using age-adjusted pancreatic cancer mortality rates for white females in 295 US counties of the Northeast (1970–1994). Simulation
studies demonstrate that Poisson kriging yields more accurate estimates of the cancer risk and how its value changes between
polygons (i.e., boundary statistic), relatively to the use of raw rates or local empirical Bayes smoother. When used in conjunction
with spatial neutral models generated by p-field simulation, the boundary analysis based on Poisson kriging estimates minimizes
the proportion of type I errors (i.e., edges wrongly declared significant) while the frequency of these errors is predicted
well by the p-value of the statistical test.
相似文献
Pierre GoovaertsEmail: |
92.
Spatially periodic vegetation patterns, forming gaps, bands, labyrinths, or spots, are characteristic of arid and semiarid landscapes. Self-organization models can explain this variety of structures within a unified conceptual framework. All these models are based on the interplay of positive and negative effects of plants on soil water, but they can be divided according to whether they assume the interactions to be mediated by water redistribution through runoff/diffusion or by plants' organs. We carried out a multi-proxy approach of the processes operating in a gapped pattern in southwest Niger dominated by a shrub species. Soil moisture within the root layer was monitored in time and space over one month of the rainy season. Soil water recharge displayed no spatial variation with respect to vegetation cover, but the stock half-life under cover was twice that of bare areas. A kernel of facilitation by the aboveground parts of shrubs was parameterized, and soil water half-life was significantly correlated to the cumulated facilitative effects of shrubs. The kernel range was found to be smaller than the canopy radius (81%). This effect of plants on soil water dynamics, probably through a reduction of evaporation by shading, is shown to be a better explanatory variable than potentially relevant soil and topography parameters. The root systems of five individuals of Combretum micranthum G. Don were excavated. Root density data were used as a proxy to parameterize a kernel function of interplant competition. The range of this kernel was larger than the canopy radius (125%). The facilitation-to-competition range ratio, reflecting the above-to-belowground ratio of plant lateral extent, was smaller than 1 (0.64), a result supporting models assuming that patterning may emerge from an adaptation of plant morphology to aridity and shallow soils by means of an extended lateral root system. Moreover, observed soil water gradients had directions opposite to those assumed by alternative mathematical models based on underground water diffusion. This study contributes to the growing awareness that combined facilitative and competitive plant interactions can induce landscape-scale patterns and shape the two-way feedback loops between environment and vegetation. 相似文献
93.
Fecundity and survival in relation to resistance to oxidative stress in a free-living bird 总被引:1,自引:0,他引:1
Major life history traits, such as fecundity and survival, have been consistently demonstrated to covary positively in nature, some individuals having more resources than others to allocate to all aspects of their life history. Yet, little is known about which resources (or state variables) may account for such covariation. Reactive oxygen species (ROS) are natural by-products of metabolism and, when ROS production exceeds antioxidant defenses, organisms are exposed to oxidative stress that can have deleterious effects on their fecundity and survival. Using a wild, long-lived bird, the Alpine Swift (Apus melba), we examined whether individual red cell resistance to oxidative stress covaried with fecundity and survival. We found that males that survived to the next breeding season tended to be more resistant to oxidative stress, and females with higher resistance to oxidative stress laid larger clutches. Furthermore, the eggs of females with low resistance to oxidative stress were less likely to hatch than those of females with high resistance to oxidative stress. By swapping entire clutches at clutch completion, we then demonstrated that hatching failure was related to the production of low-quality eggs by females with low resistance to oxidative stress, rather than to inadequate parental care during incubation. Although male and female resistance to oxidative stress covaried with age, the relationships among oxidative stress, survival, and fecundity occurred independently of chronological age. Overall, our study suggests that oxidative stress may play a significant role in shaping fecundity and survival in the wild. It further suggests that the nature of the covariation between resistance to oxidative stress and life history traits is sex specific, high resistance to oxidative stress covarying primarily with fecundity in females and with survival in males. 相似文献
94.
Aude Tessier Mélie Sarreau Fanny Pelluard Gwenaelle André Sophie Blesson Martine Bucourt Pierre Dechelotte Laurence Faivre Thierry Frébourg Alice Goldenberg Valérie Goua Corinne Jeanne-Pasquier Fabien Guimiot Annie Laquerriere Nicole Laurent Mathilde Lefebvre Philippe Loget Martine Maréchaud Charlotte Mechler Marie-Josée Perez Jean Christophe Sabourin Alain Verloes Sophie Patrier Anne-Marie Guerrot 《黑龙江环境通报》2016,36(13):1270-1275
95.
Sophie Grima Véronique Bellon-Maurel Pierre Feuilloley Françoise Silvestre 《Journal of Polymers and the Environment》2000,8(4):183-195
During the last few years, biodegradable polymers have been developed to replace petrochemical polymers. Until now, research devoted to these polymers essentially focused on their biodegradability. There is now a need to bear out their nontoxicity. To verify this, the biodegradation must be carried out in accelerated laboratory tests which allow the metabolites and residues to be recovered. To reproduce the natural conditions (compost, field) as closely as possible, degradation experiments must be run on solid-state substrates. We review studies of aerobic degradation in solid-state substrates. This article focuses in particular on the environmental, physical, and chemical parameters (such as substrate nature, moisture, temperature, C/N ratio, and pH) that influence biodegradation kinetics. This study also aims at finding the solid substrate most adapted to residues and metabolite recovery. The most significant parameters would appear to be the substrate type, moisture content, and temperature. Inert substrates such as vermiculite are well suited to residue extraction. This review also opens the field to new research aimed at optimizing conditions for aerobic solid-state biodegradation and at recovering the metabolites and residues of this degradation process. 相似文献
96.
The urban fringe is recognized as the arena of many conflicts involving land uses and values. The development and operation of hazardous waste facilities give rise to numerous conflicts and confrontations. An analysis of three cases in Montreal's rural-urban fringe based on a review of articles in the regional press demonstrates the utility of a common conceptual framework based on the awareness cycle which is represented in five phases. The application of the sustainable development concept to the hazardous wastes issue requires adopting approaches emphasizing participation of all the actors and interests involved, right from project design to the closure and dismantling of the facility. The fundamental challenge is that of promoting the excellence of the various stakeholders in terms of the quality of their participation in order to achieve sustainable acceptability of the project, often in a modified form compared to its initial conception.Dr Pierre André is Assistant Professor and Dr Christopher R. Bryant is Full Professor in the Département de Géographie, Université de Montreal. Romain Coté has completed an MSc degree in the Hygiène du milieu et de l'environnement programme at the Université de Montreal. 相似文献
97.
In revegetation trials on disturbed riverbank sites in the Montréal region (Québec, Canada), an analysis of their structure by means of their biotic and abiotic components was undertaken. Vegetation sampling and physical surveys, together with soil analyses of 62 stands, grouped in 20 sectors, were carried out in the summer of 1986. The statistical analyses of biotic and abiotic data were executed in parallel by a hierarchical agglomerative cluster analysis (arithmetic average clustering) and by an ordination in reduced space (principal coordinate analysis). The species colonizing these riverbanks are, for the most part, ruderals from the Montréal region, of which more than 50% are introduced species. The pioneering communities characterizing these artificial habitats have had very little impact on the physical conditions of their environment; therefore, the ordination on the plant communities proves to be strongly correlated to the ordination stemming from the abiotic components. The statistical analysis retains the original sectors, underlining the fact that each human intervention generally results in the creation of a particular ecological situation. 相似文献
98.
Annie Tissot Pierre Boule Serge Lambert Jacques Lemaire Jean-Claude Palla 《Chemosphere》1985,14(9):1221-1230
A test of acute toxicity on DAPHNIA MAGNA is suggested to evaluate the efficiency of the phototransformation as a route of abiotic degradation. This test is recommended for compounds phototransformed into a complex mixture of products. Hydroquinone, 2-chloro-, 4-chloro-, 2,4-dichloro-, 2,4,6-trichloro- and pentachlorophenol were studied as examples. In any case the phototransformation is an useful depollution technique on condition the irradiation to be completed as far as the ultimate step of phototransformation. 相似文献
99.
100.
Francine Pratlong Pierre Boulot Eric Issert Martine Msika Frédéric Dupont Bruno Bachelard Pierre Sarda Jean-Louis Viala Daniel Jarry 《黑龙江环境通报》1994,14(3):191-198
One hundred and ninety women who contracted toxoplasmosis after the seventh week of pregnancy underwent antenatal diagnosis, including ultrasound examination and biological tests. Tests included Toxoplasma isolation in fetal blood and amniotic fluid by mouse inoculation, specific IgM and IgA in fetal blood, and non-specific tests. Twenty fetuses had positive specific as well as non-specific tests for Toxoplasma infection. At birth, four of these presented with clinical congenital toxoplasmosis and 12 with subclinical forms. Antenatal diagnosis enabled the detection of 83 per cent of the infected fetuses. Under specific conditions, cordocentesis permits early diagnosis and considerably reduces the number of terminations of pregnancy. 相似文献