The effect of the corticosteroid hormone cortexolone on the metabolites produced during phenanthrene biotransformation in Cunninghamella elegans

The metabolism of phenanthrene and the mammalian corticosteroid hormone cortexolone by the fungus Cunninghamella elegans was studied. The amounts of the cortexolone transformation products, cortisol and epicortisol, were affected by the presence of phenanthrene. Approximately 40% more cortisol was produced by C. elegans in cultures with phenanthrene. In contrast, epicortisol formation decreased. C. elegans transformed phenanthrene to phenanthrene trans-1,2-,3,4-, and 9,10-dihydrodiols, phenols, diphenols (diols) and glucoside conjugates of 1-, 2-, 3-, 4-, and 9-phenanthrols. Almost all of the phenanthrene initially added was metabolized to ethyl acetate extractable metabolites. In the mycelia and culture medium extracts, phenanthrol glucosides represented 80% and 94% of the total metabolites, respectively. The major metabolite was the glucoside conjugate of 1-phenanthrol. The presence of cortexolone affected the biodegradation of phenanthrene by decreasing the amounts of phenanthrene metabolites compared to control cultures.     

采煤区覆岩与地表沉陷控制技术研究及展望

煤矿开采引起覆岩及地表沉陷的控制理论与技术研究是涉及全球性灾害学科的研究内容之一。笔者通过对采动覆岩破坏特征的分析，提出了覆岩破坏与移动的“竖四带”的分区模式；并在评述传统控制技术及效果的基础上，介绍了覆岩与地表沉陷控制的新技术——离层注浆技术的原理、特点及应用前景     

The effects of perceived organizational support and perceived supervisor support on employee turnover

This study examines mediated effects of perceived supervisor support (PSS) and perceived organizational support (POS) on turnover cognitions, and their interactive effects on turnover behavior in a sample of 225 social services workers. In this study, we address a seeming contradiction in current findings regarding support and attachments to managers versus attachments to the organization itself. The POS literature suggests fully mediated causal paths to turnover from POS and PSS, through affective commitment. Whereas, the commitment, LMX, and turnover literatures suggest alternative causal paths that imply broader effects for POS and PSS on turnover. Contrary to earlier POS literature, findings showed that PSS had independent effects on turnover cognitions not mediated through POS. Model tests also indicated that POS had significant effects on turnover mediated through normative commitment, as well as affective organizational commitment. Moreover, a new significant interactive relationship was discovered such that low PSS strengthened the negative relationship between POS and turnover, while high PSS weakened it. Implications for research and practice are discussed. Copyright © 2007 John Wiley & Sons, Ltd.     

供应链系统可靠性分析

供应链是由物料获取并加工成中间件或成品 ,再将成品送到顾客手中的一些企业和部门构成的网络 ,它包括供应商 (包括供应商的供应商等 )、制造商、配送中心、零售商、最终用户等多个多级实体。除了性能以外 ,其可靠性已经成为供应链管理研究的重点。鉴于供应链中存在的诸多层次与环节致使供应链的可靠性分析十分复杂 ,为了简便起见 ,笔者认为 ,必须从单级供应链可靠性分析出发 ,再进行基于马尔可夫过程的多级供应链可靠性分析 ,最后根据分析结果 ,提出一些提高供应链可靠性的措施。该方法对供应链系统可靠性分析具有实用价值 ,其关键环节是将串联结构改变为并联结构来实现。     

木工机床切削机构产生噪声的原因及刀具降低噪声新技术

我国的木材加工企业普遍存在严重的噪声污染 ,极大地损害了工作者的身心健康 ,是迫切需要解决的重要问题。为了控制木工机床的噪声 ,分析和讨论了产生噪声的原因 ,指出切削机构是噪声的主要声源。探讨了降低噪声的途径 ,综合评述了国外木工刀具降噪新技术。在工业发达的国家 ,现代木工刀具的设计与制造均考虑了降噪措施 ,其技术原理集中于控制气流在刀槽或齿槽中涡流产生的空气动力性噪声和防止刀具振动时产生的机械噪声两方面。这些新技术已用于生产中 ,降噪效果明显 ,值得借鉴。笔者强调 ,开发低噪声木工刀具 ,保障劳动者的人体健康 ,是我国木材加工工业文明发展的标志     

Treatment of mixed contamination in water using cyclodextrin‐based materials

This study investigated the effectiveness of a cyclodextrin‐based solid material for the removal of mixed dissolved contaminants. The solid material was prepared by condensation of α‐cyclodextrin. The removal efficiency was found to be 70 percent for total heavy metals (cadmium, lead, chromium, iron, nickel, cobalt, and mercury) to 98 percent for polychlorinated biphenyls (PCBs). The optimum pH for heavy metal removal was approximately 5 and for PCBs it was in the range of 5–7. All of these heavy metals were successfully recovered from the spent cyclodextrin‐based material using nitric acid, allowing the material to be reused for further passes. The results also showed that the presence of alkaline and alkaline earth metals did not have a significant effect on the removal efficiency, indicating that the cyclodextrin‐based material could selectively remove the heavy metals of concern without being consumed by alkaline and alkaline‐earth metals. © 2006 Government of Canada.     

A rare inherited euchromatic heteromorphism on chromosome 1

Extra genetic material that is euchromatic is generally regarded to be associated with phenotypic abnormalities. However, recent studies suggest that this is not always the case. Chromosome analysis was performed on amniotic fluid cells from a 37-year-old phenotypi-cally normal patient referred for advanced maternal age. All the cells analysed showed a karyotype of 46, XY, 1p-K The 1p+ chromosome had extra genetic material of uncertain origin in chromosome band region 1p21 →31. Chromosome analysis on the father revealed a normal 46, XY male karyotype. The mother's karyotype showed the same 1p+ chromosome. C and Q banding, as well as silver staining studies, in both the mother and the fetus support the interpretation that the extra chromosomal material was euchromatic in nature. This 1p + chromosome may be characterized as a euchromatic heteromorphism. Euchromatic hetero-morphisms not associated with phenotypic abnormalities have been reported for chromosomes 9 and 16. To the best of our knowledge, this is the first report involving this type of cytogenetic anomaly on chromosome number 1 in a phenotypically normal mother and infant.