A reasoned approach towards administering COVID-19 vaccines to pregnant women

There are over 50 SARS-CoV-2 candidate vaccines undergoing Phase II and III clinical trials. Several vaccines have been approved by regulatory authorities and rolled out for use in different countries. Due to concerns of potential teratogenicity or adverse effect on maternal physiology, pregnancy has been a specific exclusion criterion for most vaccine trials with only two trials not excluding pregnant women. Thus, other than limited animal studies, gradually emerging development and reproductive toxicity data, and observational data from vaccine registries, there is a paucity of reliable information to guide recommendations for the safe vaccination of pregnant women. Pregnancy is a risk factor for severe COVID-19, especially in women with comorbidities, resulting in increased rates of preterm birth and maternal morbidity. We discuss the major SARS-CoV-2 vaccines, their mechanisms of action, efficacy, safety profile and possible benefits to the maternal-fetal dyad to create a rational approach towards maternal vaccination while anticipating and mitigating vaccine-related complications. Pregnant women with high exposure risks or co-morbidities predisposing to severe COVID-19 infection should be prioritised for vaccination. Those with risk factors for adverse effects should be counselled accordingly. It is essential to support patient autonomy by shared decision-making involving a risk-benefit discussion with the pregnant woman.     

Coordination Degree of Urban Population, Economy, Space, and Environment in Shenyang Since 1990

In the background of China's rapid urbanization, the conflicts between urban population, economy, space, and environment are intensified and complicated. This article aims to establish a coordinate assessment method for studying urban population, economy, space, and environment interactions in city scale by principal component analysis and regression analysis. On the basis of the case study on Shenyang city, the results indicated that the integrated development of urban population, economic, and space was in a poor situation from 1993 to 1999, whereas it turned better after 2000, and the urban environment improved steadily after 1998. The static coordination degree of urban integrated development and environment showed obvious periodical and fluctuant characteristics. Compared with the static coordination degree, the dynamic coordination degree appeared to be smooth and lag. The static coordination degree was elementary discoordinative in 1993, 1994, and 1999; whereas it turned to be elementary coordinative between 1995 and 2005. The dynamic coordination degree was elementary discoordinative from 1993 to 1996, whereas it became elementary coordinative overall after 1997.     

安徽沿江地带投资环境综合研究

改善投资环境吸引外资是经济发展的重要内容。安徽沿江地带是长江经济带重要的组成部分，对安徽沿江地带投资环境进行了分析与评价，并就进一步完善沿江地带宏观投资环境，推动经济联合发展提出了建议与措施。     

黄山贫困山区资源特点与治贫开发对策

黄山是我国十大风景名胜区之一，但全区经济发展水平十分落后，属安徽省贫困地区之一。本文对黄山贫困山区的资源特点与存在问题进行了综合分析，指出了本区贫困落后的主要原因，并就治贫开发提出了相应对策。     

Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s

There remain unanswered questions concerning mother-to-child-transmission of SARS-CoV-2. Despite reports of neonatal COVID-19, SARS-CoV-2 has not been consistently isolated in perinatal samples, thus definitive proof of transplacental infection is still lacking. To address these questions, we assessed investigative tools used to confirm maternal-fetal infection and known protective mechanisms of the placental barrier that prevent transplacental pathogen migration. Forty studies of COVID-19 pregnancies reviewed suggest a lack of consensus on diagnostic strategy for congenital infection. Although real-time polymerase chain reaction of neonatal swabs was universally performed, a wide range of clinical samples was screened including vaginal secretions (22.5%), amniotic fluid (35%), breast milk (22.5%) and umbilical cord blood. Neonatal COVID-19 was reported in eight studies, two of which were based on the detection of SARS-CoV-2 IgM in neonatal blood. Histological examination demonstrated sparse viral particles, vascular malperfusion and inflammation in the placenta from pregnant women with COVID-19. The paucity of placental co-expression of ACE-2 and TMPRSS2, two receptors involved in cytoplasmic entry of SARS-CoV-2, may explain its relative insensitivity to transplacental infection. Viral interactions may utilise membrane receptors other than ACE-2 thus, tissue susceptibility may be broader than currently known. Further spatial-temporal studies are needed to determine the true potential for transplacental migration.     

东方大港的探讨—利用GIS对宁波深水港的分析

根据孙中山先生提出的在我国北、东、南建立三方大港的思想，对我国东部沿海的宁波港进行了分析。在对其历史和现状分析的基础上，借助于现代的信息系统技术和遥感技术，对宁波港的水深状况和集疏运输情况进行了进一步分析，并与北、南二大深水港大连港、广州港、以及我国目前最大的上海港作了比较，提出了正在快速发展的宁波港有潜力成为我国的东方大港，为国家对港口的宏观布局提供了依据。     

乌鲁木齐市医院污水处理水平现状分析

乌鲁木齐地区共有２９家大中型医院，建立污水处理设施的共有１５家，占５１．７％，其中处理后达标排放的占３１．６％。从处理方法及效果来看，经一级处理的医院排水，主要监测指标仍有不同程度的超标，采用二级处理的效果则比较显著。为确保２０００年达标排放，有关部门应采用相应的措施督促大中型医院尽早用二级处理方法处理其排水。     

A mobile flight case learning system for ATC miscommunications

Aviation’s highest priority is safety. The primary risk to safety derives not from automated systems but from human factors, most notably air traffic control. We present results from development of a flight case learning system designed to operate on mobile phones used by air traffic controllers (ATCs). Our system takes advantage of key Ontology concepts, a case-based system development procedure, human-centered design (HCD) strategies, and appropriate small-screen interface design protocols. A questionnaire to assess user interaction satisfaction (QUIS) was deployed for subsequent usability testing and to verify acceptance of, and satisfaction with, the system. Twelve subjects participated in the questionnaire-based evaluation of subjective satisfaction. In addition, two flight experts served on a review panel for domain knowledge verification and acceptance of the interface design. Our results confirm that the system is a suitably designed mobile learning system that can accelerate self-learning for ATCs.     

Photoelectro-Fenton mineralization of phenol through optimization of ferrous regeneration

The degradation of phenol in acidic solution at pH 3 has been investigated under various photo- and electrochemical conditions. A laboratory-scale reactor on which were mounted net electrodes (RuO₂/IrO₂-coated Ti anodes (DSA) and stainless steel cathodes) and 254 nm UV lamps was established to effectively reduce ferric reagents. The experimental results of the photoelectron-chemical reaction suggested that the current efficiency of reducing ferric ion was improved by increasing the number of electrodes used, and the UV lamps were important to inducing the reduction of ferric carboxylates, which were the major intermediates that were formed upon a particular degree of phenol oxidation. Accordingly, the addition of an initial concentration of 400 ppm ferrous salt and 10,200 ppm hydrogen peroxide (in a continuous mode) resulted in the removal of over 92 % of TOC (initial phenol?=?2,000 ppm, TOC?=?1,532 ppm) by 4 h of the photoelectro-Fenton and the sequential 2 h of the photo-Fenton processes. HPLC was utilized to monitor the formation of aromatic and carboxylate byproducts, and revealed that the aid of photo irradiation eliminated most of the oxalate residue from the final solution, which would have contributed to the 25 % of the TOC that was inactive in the electrolytic system.