Mechanism of Deca-BDE-induced apoptosis in Neuro-2a cells: Role of death-receptor pathway and reactive oxygen species-mediated mitochondrial pathway

Decabromodiphenyl ether (BDE-209) is a prevalent polybrominated diphenyl ether (PBDE) congener known to have neurotoxicity. Effects of BDE-209 on Neuro-2a cells were performed in the present study and the possible apoptotic pathway was discussed. Results indicated that BDE-209 induced Neuro-2a cell apoptosis, increased the protein expression of Fas and Fas-associated death domain-containing protein (FADD) and activated the caspase-8 and -3 activities in a concentration-dependent manner, inferring the death-receptor pathway was involved in the apoptotic process. Meanwhile, BDE-209 exposure increased the Bax/Bcl-2 ratio and decreased the cellular mitochondrial membrane potential (MMP) which led to cytochrome C released to the cytoplasm. The intracellular caspase-9 was elevated simultaneously, which caused downstream caspase cascade and triggered cell apoptosis. Moreover, BDE-209 exposure increased cellular reactive oxygen species (ROS) level in a concentration-dependent manner and the addition of N-acetyl-l-cysteine (NAC), known as ROS scavengers, obviously reduced the apoptotic rate and a positive relationship was observed between the degree of apoptosis blocking and the loss of MMP and ROS production. We thus concluded that BDE-209 induced Neuro-2a cell apoptosis via the combination of the death-receptor signaling pathway and the mitochondrial signaling pathway. The elevated ROS production was considered to magnify the intracellular apoptosis signal and played a crucial role in apoptosis of Neuro-2a cells induced by BDE-209.     

Cover features and new Associate Editors of the Journal of Environmental Sciences

正We are very pleased to announce that five Associate Editors have joined the editorial team of the Journal of Environmental Sciences(JES).Professors/Drs.Yong Cai,Paul Lam,Jonathan Martin,Michael Plewa,and Po Keung Wong bring a wealth of expertise in environmental sciences.As preeminent scientists in their chosen areas of research,they have made outstanding contributions to the discipline of environmental     

中国沿海港口总体规划环境影响评价研究

中国港口规划环境影响评价自2004年正式启动,至今已经过十余年的探索和发展,各方面都取得了很好的成效,逐步进入到规范化和成熟化阶段。但在中国环境保护发展的新形势下,港口规划环评工作仍在工作机制和技术方法等方面存在诸多问题。本研究系统性回顾了中国港口规划环评的发展历程,梳理了环评管理架构和工作流程,分析了中国港口规划环评存在的主要问题,并从工作机制、成果落实和技术方法等方面提出了相应的对策建议。     

哈尔滨市大气主要污染物浓度变化与城市发展因素影响分析研究

采用Daniel趋势检验法对哈尔滨市近年来SO2、NO2和PM10年均浓度变化趋势分析,并对城市总人口与经济、产业结构、民用汽车保有量和能源状况五个城市发展因素进行数据统计分析,用SPSS探究城市发展过程中影响大气污染的因素及相关性.结果表明:浓度变化趋势是SO2明显上升;NO2缓慢上升;PM10整体明显下降,但在2013年点突增至了0.119 mg/m3.SO2与NO2显著相关,相关系数为0.533.经统计,哈尔滨人口经济发展、产业结构调整较为缓慢,全市民用汽车保有量增加并未对NO2浓度影响显著,能源结构依然以煤为主,虽然能源强度提升,但也存在着煤质、散煤的问题.哈尔滨市各城市发展因素与污染物浓度关联度不显著.     

Distribution and mode of occurrence of uranium in bottom ash derived from high-germanium coals

The radioactivity of uranium in radioactive coal bottom ash(CBA) may be a potential danger to the ambient environment and human health. Concerning the limited research on the distribution and mode of occurrence of uranium in CBA, we herein report our investigations into this topic using a number of techniques including a five-step Tessier sequential extraction, hydrogen fluoride(HF) leaching, Siroquant(Rietveld) quantification, magnetic separation, and electron probe microanalysis(EPMA). The Tessier sequential extraction showed that the uranium in the residual and Fe–Mn oxide fractions was dominant(59.1%and 34.9%, respectively). The former was mainly incorporated into aluminosilicates,retained with glass and cristobalite, whereas the latter was especially enriched in the magnetic fraction, of which about 50% was present with magnetite(Fe_3O_4) and the rest in other iron oxides. In addition, the uranium in the magnetic fraction was 2.6 times that in the non-magnetic fraction. The experimental findings in this work may be important for establishing an effective strategy to reduce radioactivity from CBA for the protection of our local environment.     

石油钻井废水处理研究进展

本文简述了处理石油钻井废水的研究现状,综述了常用的处理方法并对各种方法适用的范围以及优势和不足进行了分析。     

基于虚拟水的江苏省2009年水足迹分析

水足迹是基于消费基础的水资源利用情况的指示器,通过虚拟水贸易获得最大利益是水足迹分析方法的重要发展方向。在基于虚拟水计算方法的基础上对江苏省2009年水足迹进行了计算和评价,结果表明：2009年江苏省水足迹为866．75×10^8m^3,人均水足迹为1829m^3／人·年,水匮乏度为217％,水资源消费自给率为86．33％,较高的水资源自给率和水足迹给江苏省生态环境造成了巨大压力。实施虚拟水战略、改变消费模式、提高水资源利用率,已经成为缓解江苏省水资源短缺现状,实现水资源可持续利用的有效途径。     

浅议石油企事业HSE管理体系文件的编制

分析了企业在HSE管理体系文件的结构和形式、编制原则、步骤和方法上存在的问题,并有针对性地提出了国内石油企业在HSE管理体系文件编制过程中的注意事项。