First-trimester maternal serum human chorionic gonadotrophin as a marker for fetal chromosomal disorders

The Dutch Working Party on Prenatal Diagnosis has initiated a study on the possibilities of first-trimester screening for fetal chromosomal disorders. We report on maternal serum human chorionic gonadotrophin (MS-hCG) measurements in 1348 pregnancies with a chromosomally normal fetus and 53 pregnancies with a chromosomally abnormal fetus. The median MS-hCG concentration in 24 pregnancies with Down's syndrome was 1.19 multiples of the normal median (MoM). The MS-hCG distributions in normal and Down's syndrome pregnancies did not differ significantly (t-test: t = 1.945, p >0.05). We also found no difference between normal pregnancies and pregnancies with other chromosomal disorders (six cases of trisomy 18, MoM = 0.80; four cases of sex chromosome abnormality, MoM = 1.01; 17 cases of chromosomal mosaicism in chorionic villi, MoM = 1.11). Selecting an upper limit at the 90th centile could detect 25 per cent of pregnancies with Down's syndrome. We conclude that, in the first trimester, MS-hCG as a screening factor for Down's syndrome is of minor value. However, MS-hCG could be a useful factor in a first-trimester screening programme based on a combination of markers.     

采用厚壁离心铸坯旋压成形大直径高纯铝筒工艺研究

此文介绍采用壁厚达90mm的离心铸坯,旋压成形大直径高纯铝筒的工艺试验。讨论了旋压中出现的各种问题,从而确定了合理的工艺参数,旋出了符合技术要求的大直径筒形件。     

圆筒形零件拉深的CAD

此文综述了利用计算机对圆筒形零件拉深进行全面设计,从圆筒形工件拉深时工艺参数的计算到最终工艺卡的绘制,以及在中间拉深过程中拉深系数分配的优化设计都作了圆满的解决.这对圆筒形工件的拉深具有重要的实际意义.     

不锈钢导管挤压扩口工艺与模具设计

介绍了飞机不锈钢导管原位挤压扩口工艺和模具设计.该模具具有结构简单、易于加工、更换方便等特点,该工艺不仅适用于飞机导管修理,而且还可供其它设备导管修理时参考.     

A new hypothesis for the etiology of Kaschin-Beck disease

Kaschin-Beck disease (KBD) could be exogeneous free radical induced endemic osteoarthropathy under conditions of lacking necessary antioxidant defences.especially selenium-cored defence in Chinese eco-en-vironment. Experimental evidences have been provided for the internal relations among previously suggested pathologic factors, i.e., selenium deficiency, organic matters of drinking waterand mycotoxins from contaminated grains, based on the facts that the former is a preventory factor while the others are exogenous freeradical carriers. ESR spectrum shows that these exogenous free radical carriers have a property of semi-quinone compounds and are toxic in in-vitro cartilage cell culture and animal tests in inducing lipid peroxidation process.     

Ecological and environmental characteristics and management planning of Mawei Economic Development District

The natural and social background of the district was described, and the major ecological and environmental problems were analysed. The measures and planning for the ecological and environmental protection were recommended. Systematic analysis method and environmental mathematical models were suggested to be used for the ecological and environmental general planning in this paper.     

倒葫芦张开状零件成形模具的设计

此文对倒葫芦张开状零件成形模具的设计进行了分析和计算,结论是所采用的模具结构成形类似零件是可行的。     

应用于垂直面非垂直切断的变形切断法

此文提出冲裁中,对于垂直面及垂直面非垂直切断的问题。并根据板料的回弹特性,提出了变形切断法,用普通模具,得以简便地解决提出的问题。     

Early prenatal diagnosis of genetic microcephaly

We report a new case of prenatal diagnosis of recessive microcephaly by ultrasound examination allowing termination of pregnancy at 25 weeks gestation.     

Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses

We measured the maternal serum cancer antigen 125 (MS-CA 125) levels in 98 nonpregnant women, 765 first- and second-trimester pregnancies with chromosomally-normal fetuses, and 54 chromosomally-abnormal pregnancies. To determine the MS-CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter-assay variability. The median MS-CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non-pregnant women. We found no difference between normal and Down's syndrome (n = 29) pregnancies ( t-test: t = 0·57, p >0·5). The MS-CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS-CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy.