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排序方式: 共有568条查询结果,搜索用时 375 毫秒
361.
Clara Illi Josefine Koenigbauer Wolfgang Henrich Laura Fangmann Charlotte Reinhardt Sophia Ossmann Alexander Weichert 《黑龙江环境通报》2023,43(11):1459-1462
Germline pathogenic variants in isocitrate dehydrogenase 1 (IDH1) can lead to a rare neurodevelopmental disorder called metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria, including severe skeletal and cerebral anomalies. To the best of our knowledge, no prenatal case of an IDH1 pathogenic variant has been reported in literature. Somatic sequence variants in IDH1/2 genes are described in distinct cancers, premalignant diseases and rare inherited metabolic disorders. Amniocentesis and further genetic testing including trio exome sequencing were performed due to suspicious findings on a second trimester routine prenatal ultrasound examination. The fetus was found to have growth restriction, cerebral abnormalities (ex vacuo hydrocephalus, cerebellar and vermian hypoplasia, corpus callosum dysgenesis), brachycephaly, narrow chest, persistent left superior vena cava, liver calcifications, hyperechogenic bowel, short tubular bones and joint contractures. A de novo heterozygous variant in the IDH1 gene was detected via trio exome sequencing. The prenatal diagnosis of a de novo pathogenic variant in IDH1 in a fetus with the described phenotype, obtained through trio exome sequencing, helped parents and providers with an informed decision making about pregnancy management. 相似文献
362.
Human exposure to polycyclic aromatic hydrocarbons (PAH) via daily liquid consumption (primarily through the intake of drinking water) is estimated using model calculations based on the indicator substance benzo(a)pyrene. The additional contribution to oral exposure by a consumption of solid nutrients, and by soil and dust ingestion, are evaluated using typical background conditions in Germany (conurbations of North-Rhine-Westphalia). A series of further scenarios is then applied to examine the influence of elevated PAH concentrations in the daily intake of liquid. The degree of PAH exposure via liquid only equals or exceeds the exposure via the solid fraction of the diet under very specific conditions. The contribution via liquid consumption to a total lifelong exposure of both BAP and PAH caused by dietary intake may be estimated as approximately 4 %. It increases to 56 % under a level equivalent to the Dutch intervention value for groundwater and reaches 90 % under a level equivalent to the WHO guideline for drinking water. Considering occupants who live on PAH contaminated garden allotments with private wells, the highest degree of exposure is caused by vegetables followed by house dust, then liquid diet and finally by soil. Finally, the model approach is used for evaluating the success of potential remedial treatments with respect to exposure reduction. In addition to the application of average values, conservative estimates of exposure in terms of 95 % values are set out in this publication based on sumulation methodologies. 相似文献
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Schröder HC Brandt D Schlossmacher U Wang X Tahir MN Tremel W Belikov SI Müller WE 《Die Naturwissenschaften》2007,94(5):339-359
Biomineralization, biosilicification in particular (i.e. the formation of biogenic silica, SiO2), has become an exciting source of inspiration for the development of novel bionic approaches following “nature as model”.
Siliceous sponges are unique among silica forming organisms in their ability to catalyze silica formation using a specific
enzyme termed silicatein. In this study, we review the present state of knowledge on silicatein-mediated “biosilica” formation
in marine sponges, the involvement of further molecules in silica metabolism and their potential application in nanobiotechnology
and medicine.
Werner E. G. Müller dedicated this study to Prof. Vera Gamulin (Rudjer Boskovic Institute, Zagreb, Croatia) in honour of her
unique contributions in molecular evolution. 相似文献
365.
Ying Li Godelieve C. M. L. Page-Christiaens Johan J. P. Gille Wolfgang Holzgreve Sinuhe Hahn 《黑龙江环境通报》2007,27(1):11-17
Achondroplasia is the most common form of short-limbed dwarfism in humans and is caused by mutations in the FGFR3 gene. Currently, prenatal diagnosis of this disorder relies on invasive procedures. Recent studies have shown that fetal single gene point mutations could be detected in cell-free DNA (cf-DNA) from maternal plasma by either the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) assay with single allele base extension reaction (SABER) approach or the size fractionation of cf-DNA in maternal plasma. Here, we combined the two approaches to non-invasively examine the fetal G1138A mutation in maternal plasma. cf-DNA was extracted from maternal plasma samples obtained from two pregnant women at risk for achondroplasia. The fetal G1138A mutation was determined by the analysis of size-fractionated cf-DNA in maternal plasma using MALDI-TOF MS with SABER approach and homogenous MassEXTEND (hME) assay, respectively. The fetal G1138A mutation was detectable in the two achondroplasia-affected pregnancies by the analysis of cf-DNA in maternal plasma using MALDI-TOF MS. However, the size-fractionation approach led to a more precise detection of the fetal mutation in both analyses. This analysis would be suitable for non-invasive prenatal diagnosis of diseases caused by fetal single gene point mutations. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
366.
Bernd Page Wolfgang Kreutzer 《Environmental science and pollution research international》2006,13(6):441-441
Summary The main readership are students in the field of informatics. In most parts, other interested scientists from environmental
disciplines get some insights in the field of environmental modelling and software. The book can be recommended broadly. With
the last chapter ‘Simulation in Practice’, this work may also be useful for commercial application. With chapter 14, the authors
contribute to the increasingly important topic of E-Learning. 相似文献
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