Two-dimensional spectrophotometry and pseudo-color representation of chemical reaction patterns

The formation of spatio-temporal patterns in layers of chemical and biochemical media is observed and quantified by a two-dimensional spectrophotometer based on a computerized video equipment with high spatial, temporal, and intensity resolution. Images are shown, to some extent, in pseudo-colors. The use of pseudo-colors and three-dimensional perspective representations enhances the perception of the information contained in an image and the inherent order of the spatial structures.     

Activity of biotin-dependent and gaba metabolizing enzymes in chorionic villus samples: Potential for 1st trimester prenatal diagnosis

We have documented the presence of five mitochondrial enzymes in samples of chorionic villus tissue and measured the levels of activity. Three of the enzymes catalyse biotindependent reactions. These are propionyl-CoA carboxylase, 3-methylcrotonyl-CoA carboxylase and pyruvate carboxylase. the other enzymes. 4-aminobutyric acid aminotransferase and succinic semialdehyde dehydrogenase, are involved inthe degradation of the central inhibitory neurotransmitter GABA. Distinct diseases in whichthere is deficiency of each of these enzymes have been documented in man. Significant levels of activity were observed for all five enzymes in chorionic villus tissue. This methodology should permit early prenatal diagnosis of deficiencies of these enzymes by chorionic villus biopsy in the first trimester.     

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