Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling

We have summarized the molecular and cellular events involved in nickel (Ni) compound induced carcinogenesis. The major hypothesis for nickel carcinogenic action has involved the ability of the Ni compound to deliver high concentrations of Ni intracellularly, enter the nucleus and interact with chromatin. Ni has been found to selectively damage heterochromatin, and a major action of Ni is its ability to silence the expression of genes located near heterochromatin by inducing a loss of histone H4 and H3 acetylation and DNA hypermethylation. When Ni silences critical genes, such as tumor suppressor genes, the cell is altered to a greater state of neoplastic transformation. The carcinogenic hazard of Ni compounds has been directly related to the ability of that Ni compound to raise the intracellular Ni ions. The mechanisms of Ni-induced gene silencing will be discussed. However, recently it has been found that soluble Ni ions can interact with the cell surface receptors and activate cell signaling resulting in the induction of a variety of cellular genes. In particular, the Ca and hypoxia inducible factor pathway is activated in all cells exposed to soluble Ni ions. In the case of HIF-1 induction, a cell is now equipped with the expression of a variety of genes that will allow the cell to survive the lack of oxygen and thus should enable a previously initiated cancer cell to progress into a full malignant state and metastasize. These new findings support the view that soluble Ni ions exhibit carcinogenic potential by activating cell promotion and lend strength to the epidemiological data showing soluble Ni to be associated with cancer risk in Ni refinery workers.     

Carbon disulfide at a Chinese viscose factory external and internal exposure assessment

This article presents the results of carbon disulfide exposure measurements in a Chinese viscose rayon factory. The objectives of the study were to identify the external exposure levels at a large factory and to investigate the 2-thiothiazolidine-4-carboxylic acid (TTCA) concentrations in the urine of the subjects who were exposed to carbon disulfide in the working place atmosphere. The metabolism of carbon disulfide in the exposed subjects was also studied in order to demonstrate the best points in time for the internal exposure sampling. The measurement of the amount of personal exposure to carbon disulfide in the air of the workplace was performed by GC-FPD; the presence of TTCA in the workers urine was analyzed by use of a modified HPLC method. The kinetics of TTCA excretion was studied by analyses at different time-points both during and after exposure to carbon disulfide in the subjects. A total of 155 personal samples were obtained. The carbon disulfide concentration in the staple viscose hall was 13.72 +/- 1.12 mg m-3 in terms of the geometric mean +/- geometric standard deviation, and was 20.05 +/- 1.33 mg m-3 in the filament spinning hall. The TTCA values in the subjects who worked in the staple spinning hall were 1.18 +/- 0.43 mg g-1 creatinine and 1.07 +/- 0.38 mg g-1 creatinine for subjects working in the filament spinning hall. The best time for TTCA sampling is at the end of the working shift, the TTCA excretion was stable for a period of 4-12 h after exposure of the subjects to the carbon disulfide. It might be that the Chinese have different anthropometric characteristics; a sampling bias may therefore appear among different races.     

废钻井液固化实验研究

利用经实验筛选的固化剂配方对废钻井液进行了固化处理的室内配方研究。结果表明,经该固化剂配方处理后的固结材料在水中浸泡5d后的浸出液在色度、化学需氧量、pH值、石油类、悬浮物含量和重金属含量等指标方面可达到国家《污水综合排放标准》(GB8978-1996)中的二级标准。     

氯离子选择性电极法测定钻井废水氯离子含量

利用氯离子选择性电极测定钻井废水中的氯离子含量，分别用两种方法对钻井废水进行了预处理，氯离子在0-250mg/L的范围内线形关系良好，相关系数为0.9968,并且重现性和选择性良好、精密度与准确度较理想。     

山东省水环境自动监测监控系统数据的应用设计和使用方法

山东省水环境自动监测监控子系统的主要功能是将全省水质自动站数据利用计算机网络、数据仓库等技术导入到环境监测数据仓库中，实现全省水环境自动监测的统一监控和监测信息的自动管理和发布。本文简单介绍了系统担制中心端监测数据统计应用部分的功能设计和实现方法。     

云南省生物多样性与生态安全形势研究

云南省以其得天独厚的自然条件孕育了丰富而又脆弱的生物多样性资源，然而外来物种入侵破坏了云南的生物多样性，威胁到国家的生态安全。分析了外来物种入侵、生物多样性及生态安全三者之间的关系，提出生物多样性资源是我国的核心竞争力所在，要将维护生态安全提升到国家战略高度予以重视，同时采取多种措施防范外来物种入侵。     

二次催化-固定床生物氧化降解焦化废水的试验研究

制备了一种铁碳基／过渡金属复合催化剂，其物质摩尔配比为Fe：C：TiO2：MnO2：ZnO=2：1：1：1：0．3，使用该催化剂拟定了二次催化—固定床生物氧化降解流程。在pH＝6、温度=90℃的条件下，用该流程处理煤化工工业所产生的洗煤气净化脱酚、蒸氨剩余废水，在无需对原废水进行稀释的前提下可很好地对此废水进行处理，使处理后的出水指标达到《污水综合排放标准》（GB89r78—1966）中规定的二级排放标准。     

山东省城市空气自动监测监控系统数据的应用设计和使用方法

山东省城市空气自动监测监控系统的主要功能是将全省城市自动监测站数据利用计算机网络、数据仓库等技术导入到环境监测数据仓库中，实现全省城市空气质量自动监测的统一监控和监测信息的自动管理和发布。本文简单介绍了系统控制中心端监测数据统计应用部分的功能设计和实现方法。     

某厂化学装置爆炸对设备房结构的损坏——调查与模拟分析

在对某厂化学爆炸所作的现场调查的基础上，对设备房钢筋混凝土框架结构构件的受损状况进行了分类描述，采用有限元方法对框架结构在静力和爆炸冲击荷载下的反应进行了模拟分析，分析结果与现场调查情况基本一致，给出了一些有意义的结论。     

古代黄河中游的环境变化和灾害——对都城迁移发展的影响

都城的选址、建设和迁移发展必须以环境资源为基础。我国古代的国家都城在黄河中游反复迁移，以至最后东迁南迁。在这个过程中，环境变迁和灾害一直是重要的驱动因素之一。通过统计分析历史时期洪涝和干旱灾害，以及气候水文变化资料，结合古都所在地的环境资源条件分析讨论，揭示了黄河中游环境变化和灾害对都城迁移发展的影响。都城在长安与洛阳之间的反复迁移，以及后来的东移开封，和南移到长江下游平原，环境的变迁是重要的驱动力之一。