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排序方式: 共有218条查询结果,搜索用时 15 毫秒
101.
102.
Jan A. Deprest Alan W. Flake Eduard Gratacos Yves Ville Kurt Hecher Kypros Nicolaides Mark P. Johnson François I. Luks N. Scott Adzick Michael R. Harrison 《黑龙江环境通报》2010,30(7):653-667
Fetal diagnosis prompts the question for fetal therapy in highly selected cases. Some conditions are suitable for in utero surgical intervention. This paper reviews historically important steps in the development of fetal surgery. The first invasive fetal intervention in 1963 was an intra-uterine blood transfusion. It took another 20 years to understand the pathophysiology of other candidate fetal conditions and to develop safe anaesthetic and surgical techniques before the team at the University of California at San Francisco performed its first urinary diversion through hysterotomy. This procedure would be abandoned as renal and pulmonary function could be just as effectively salvaged by ultrasound-guided insertion of a bladder shunt. Fetoscopy is another method for direct access to the feto-placental unit. It was historically used for fetal visualisation to guide biopsies or for vascular access but was also abandoned following the introduction of high-resolution ultrasound. Miniaturisation revived fetoscopy in the 1990s, since when it has been successfully used to operate on the placenta and umbilical cord. Today, it is also used in fetuses with congenital diaphragmatic hernia (CDH), in whom lung growth is triggered by percutaneous tracheal occlusion. It can also be used to diagnose and treat urinary obstruction. Many fetal interventions remain investigational but for a number of conditions randomised trials have established the role of in utero surgery, making fetal surgery a clinical reality in a number of fetal therapy programmes. The safety of fetal surgery is such that even non-lethal conditions, such as myelomeningocoele repair, are at this moment considered a potential indication. This, as well as fetal intervention for CDH, is currently being investigated in randomised trials. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
103.
Yves Ville 《黑龙江环境通报》2011,31(7):621-627
Progress in prenatal diagnosis can lead to the diagnosis of severe fetal abnormalities for which natural history anticipates a fatal outcome or the development of severe disability despite optimal postnatal care. Intrauterine therapy can be offered in these selected cases. Prenatal diagnosis is the only field of medicine in which termination is an option in the management of severe diseases. Fetal therapy has therefore developed as an alternative to fatalist expectant prenatal management as well as to termination of pregnancy (TOP). There are few standards of fetal care that have gone beyond the stage of equipoise and even fewer have been established based on appropriate studies comparing pre- and postnatal care. Several ethical questions are being raised as fetal surgery develops, including basic Hippocratic principles of patients' autonomy and doctors' duty of competence moving the boundaries between experimental surgery, therapeutic innovation and standard care. In addition, the technical success of a fetal intervention can only rarely fully predict the postnatal outcome. Managing uncertainty regarding long-term morbidity and the possibility for fetal therapy to change the risk of perinatal death into that of severe handicap remains a critical factor affecting women's choice for TOP as an alternative to fetal therapy. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
104.
Sokadjo Yves Morel Atchadé Mintodê Nicodème Kossou Hortense Désirée 《Environmental science and pollution research international》2020,27(32):40277-40285
Environmental Science and Pollution Research - This work is the first study about the joint effect (influence) of carbon dioxide emissions (CO2) from transport and anemia influence on under-five... 相似文献
105.
We report on an experiment aimed at testing the use of self-potential measurements to monitor the motion and mixing of redox reactants advected through a well-controlled, laboratory-scale, artificial aquifer system. A rectangular, plastic tank was filled up with water-saturated sand and an array of unpolarizable electrodes was installed in the sand body. A nearly uniform, steady-state flow was established by tilting the tank and controlling the water level in reservoirs at both ends. Then, we simultaneously injected a known quantity of KMnO(4) and FeCl(2), respectively, into two separate compartments forming the upstream reservoir. We thus generated two abrupt fronts, one oxidizing and the other reducing, which subsequently travelled in parallel by advection through the sand body. The KMnO(4) and FeCl(2) solutions were in contact and reacted with each other in a region located along the median vertical plane parallel to the flow direction. During flow, the electrical potential differences between each electrode and a reference located in the downstream reservoir were recorded. In the unreacted FeCl(2) region the electric potential showed sudden variations successively occurring at increasing distances in the flow direction, associated with the passage of the FeCl(2) front. These signals essentially corresponded to the junction potential produced by the difference in ionic mobility of Fe(2+) and Cl(-). In the unreacted KMnO(4) region sharp signals, but with much smaller amplitudes, were also observed. Near the vertical median plane on the FeCl(2) side, we observed a second front associated with the spreading of the reaction zone. The shape and evolution of the reaction zone was largely controlled by the precipitation of Fe(OH)(3). 相似文献
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Camille Codaccioni Olivier Picone Véronique Lambert Paul Maurice Léo Pomar Norbert Winer Laurent Guibaud Rose-Anne Lavergne Anne-Hélène Saliou Dorothée Quinio Alexandra Benachi Catherine Noel Yves Ville Fabrice Cuillier Christelle Pomares Nicole Ferret Denis Filisetti Anne-Sophie Weingertner Valérie Vequeau-Goua Estelle Cateau Guillaume Benoist Martine Wallon Marc Dommergues Isabelle Villena Laurent Mandelbrot 《黑龙江环境通报》2020,40(13):1741-1752
109.
Nélieu Sylvie Lamy Isabelle Karolak Sara Delarue Ghislaine Crouzet Olivier Barraud Claire Bimbot Maya Allaoui Fatima Hanot Christophe Delorme Arnaud Lévi Yves Hulot Florence D. Baudry Emmanuelle 《Environmental science and pollution research international》2021,28(42):59256-59267
Environmental Science and Pollution Research - Ponds are important for their ecological value and for the ecosystem services they provide to human societies, but they are strongly affected by human... 相似文献
110.
Gihad E. Chalouhi Anne-Élodie Millischer Houman Mahallati Nathalie Siauve Andrew Melbourne David Grevent Nicolas Vinit Laurence Heidet Yves Aigrain Yves Ville Thomas Blanc Laurent J. Salomon 《黑龙江环境通报》2020,40(1):100-109
Fetal anomalies are detected in approximately 2% of all fetuses and, among these, genitourinary tract abnormalities account for 30% to 50% of all structural anomalies present at birth. Although ultrasound remains the first line diagnostic modality, fetal MRI provides important additional structural and functional information, especially with the development of faster sequences and the use of functional sequences. The added value of MRI-based imaging is three-fold: (a) improvement of diagnostic accuracy by adequate morphological examination, (b) detection of additional anomalies, and (c) in addition, MRI has the potential to provide information regarding renal function. In this review, we describe the role of fetal MRI in the anatomical evaluation of renal and urogenital tract anomalies, and we also touch upon the contribution of functional MRI to the diagnostic workup of these conditions. 相似文献