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91.
Paule Bénit Jean-Paul Bonnefont Ali Kara Mostefa Christine Francannet Arnold Munnich Pierre F. Ray 《黑龙江环境通报》2001,21(4):279-283
Tuberous sclerosis (TSC) is a frequent autosomal-dominant condition (affecting 1 in 6000 individuals) caused by various mutations in either the hamartin (TSC1) or the tuberin gene (TSC2). This allelic and non-allelic heterogeneity makes genetic counseling and prenatal diagnosis difficult, especially as a significant proportion of TSC cases are due to de novo mutations. For this reason the identification of the disease causing mutation is mandatory for accurate counseling, yet current mutation detection methods such as single-strand conformation polymorphism (SSCP) or denaturing gradient gel electrophoresis (DGGE) are labor intensive with limited detection efficiency. Denaturing high-performance liquid chromatography (DHPLC) is a high-throughput, semi-automated mutation detection system with a reported mutation detection rate close to 100% for PCR fragments of up to 800 bp. We used a recently described DHPLC assay allowing the efficient detection of mutations in TSC1 to analyze the DNA extracted from a chorion villus sample in order to perform a prenatal diagnosis for TSC. The fetus was found not to have inherited the deleterious mutation and the DHPLC diagnosis was confirmed by haplotype analysis. This represents the first DHPLC-based prenatal diagnosis of a genetic disease. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
92.
Small-scale on-site treatment of fecal matter: comparison of treatments for resource recovery and sanitization 总被引:1,自引:0,他引:1
Kelova Mariya E. Ali Aasim M. Eich-Greatorex Susanne Dörsch Peter Kallenborn Roland Jenssen Petter D. 《Environmental science and pollution research international》2021,28(45):63945-63964
Environmental Science and Pollution Research - On-site small-scale sanitation is common in rural areas and areas without infrastructure, but the treatment of the collected fecal matter can be... 相似文献
93.
Ali Naderi Beni Michael Kühn Robert Meyer Christoph Clauser 《Environmental Modeling and Assessment》2012,17(4):337-351
We study opportunities for CO2 sequestration in geological formations of the state North Rhine Westphalia in Germany. Simulations are performed for evaluating a potential site within the Bunter sandstone formation near the town of Minden in a depth?of around 3,000 m using the numerical simulator TOUGHREACT. Our focus is on three CO2 storage mechanisms: (1) hydrodynamic trapping, (2) dissolution trapping, and (3) mineral trapping. The results show that due to buoyancy the injected CO2 phase initially migrates towards the top of the reservoir and is hydrodynamically trapped beneath the confining layer of the cap rock. Then, the CO2 spreads laterally and dissolves partially in the formation water. The dissolution of CO2 results in an increase of the density of the brine causing a downward migration until it settles after 10,000 years at the bottom of the reservoir. The simulations indicate that after 10,000 years, 15% (17 Mt) from a total of 114 Mt injected CO2 are trapped hydrodynamically, 20% (23 Mt) are trapped by dissolution, and 65% (74 Mt) are fixed in newly formed carbonates such as dawsonite, ankerite, and siderite. Within our study pressure increases near the injection well by a factor of 1.1 which is lower than the upper limit usually accepted in gas storage operations. The mineral reactions cause a net decrease of porosity and in turn a decrease of permeability down to 9% of the initial value in parts of the reservoir. 相似文献
94.
Heavy metal contamination from mining sites in South Morocco: 1. Use of a biotest to assess metal toxicity of tailings and soils 总被引:2,自引:0,他引:2
Our work was conducted to investigate the heavy metal toxicity of tailings and soils collected from five metal mines located in the south of Morocco. We used the MetPAD biotest Kit which detects the toxicity specifically due to the heavy metals in environmental samples. This biotest initially developed to assess the toxicity of aquatic samples was adapted to the heterogeneous physico-chemical conditions of anthropogenic soils. Contrasted industrial soils were collected from four abandoned mines (A, B, C and E) and one mine (D) still active. The toxicity test was run concurrently with chemical analyses on the aqueous extracts of tailings materials and soils in order to assess the potential availability of heavy metals. Soil pH was variable, ranging from very acidic (pH 2.6) to alkaline values (pH 8.0-8.8). The tailings from polymetallic mines (B and D) contained very high concentrations of Zn (38,000-108,000 mg kg(-1)), Pb (20,412-30,100 mg kg(-1)), Cu (2,019-8,635 mg kg(-1)) and Cd (148-228 mg kg(-1)). Water-extractable metal concentrations (i.e., soil extracts) were much lower but were highly toxic as shown by the MetPAD test, except for soils from mines A, E and site C3 from mine C. The soil extracts from mine D were the most toxic amongst all the soils tested. On this site, the toxicity of soil water extracts was mainly due to high concentrations of Zn (785-1,753 mg l(-1)), Cu (1.8-82 mg l(-1)) and Cd (2.0-2.7 mg l(-1)). The general trend observed was an increase in metal toxicity measured by the biotest with increasing available metal contents in tailings materials and soils. Therefore, the MetPAD test can be used as a rapid and sensitive predictive tool to assess the heavy metal availability in soils highly contaminated by mining activities. 相似文献
95.
Ahmed M. Reda Ahmed Hamza H. Ali Ibrahim S. Taha Mahmoud G. Morsy 《International Journal of Green Energy》2017,14(1):75-85
In this study, an experimental investigation on the performance of a small-scale residential-size solar-driven adsorption (silica gel-water) cooling system that was constructed at Assiut University campus, Egypt is carried out. As Assiut area is considered as hot, arid climate, field tests for performance assessment of the system operation during the summer season are performed under different environmental operating conditions. The system consists of an evacuated tube with a reflective concentration parabolic surface solar-collector field with a total area of 36 m2, a silica gel-water adsorption chiller of 8 kW nominal cooling capacity, and hot and cold water thermal storage tanks of 1.8 and 1.2 m3 in volume, respectively. The results of summer season field test show that under daily solar insolation varying from 21 to 27 MJ/m2, the solar collectors employed in the system had high and almost constant thermal efficiency. The daily solar-collector efficiency during the period of system operation ranged from about 50% to 78%. The adsorption chiller performance shows that the chiller average daily coefficient of performance (COP) was 0.41 with the average cooling capacity of 4.4 kW when the cooling-water and chilled-water temperatures were about 31°C and 19°C, respectively. As the chiller cooling water is cooled by the cooling tower in the hot arid area, the cooling water is at a higher temperature than the design point of the chiller. Therefore, an experiment was carried out using the city water for cooling. The results show that an enhancement in the chiller COP by 40% and the chilling power by 17% has been achieved when the city water was 27.7°C. 相似文献
96.
Monavari SM Omrani GA Karbassi A Raof FF 《Environmental monitoring and assessment》2012,184(4):1841-1846
Environment problems associated with the generation of waste are part of societal changes where households play an important
role. These societal changes influence the size, structure and characteristic of given households. For the effective planning
of solid-waste handling infrastructure, it is essential to know the quantity of waste generation and its composition. This
paper presents the findings of a study carried out in an urban municipal area in Iran to determine the household solid-waste
generation rate and waste composition based on field surveys and to determine the related socioeconomic parameters. The dependent
variables were waste generation and composition, and independent variables were family size, family employment, age, number
of room and education. Over 400 sample households were selected for the study using a stratified random sampling methodology
and from five different socioeconomic groups. Waste collected from all groups of households were segregated and weighted.
Waste generation rate was 5.4 kg/household/day. Household solid waste comprised of ten categories of wastes and with the largest
component (76.9%). The generation and composition of household solid waste were correlated with family size, education level
and households income. This paper adequately suggests new insights concerning the role of socioeconomic parameters in affecting
the generation of household waste. 相似文献
97.
Mustafa Ali Wenping Wang Nawaz Chaudhry 《Journal of the Air & Waste Management Association (1995)》2016,66(10):1012-1018
This study was meant to determine environmental aspects of hospital waste management scenarios using a life cycle analysis approach. The survey for this study was conducted at the largest hospital in a major city of Pakistan. The hospital was thoroughly analyzed from November 2014 to January 2015 to quantify its wastes by category. The functional unit of the study was selected as 1 tonne of disposable solid hospital waste. System boundaries included transportation of hospital solid waste and its treatment and disposal by landfilling, incineration, composting, and material recycling methods. These methods were evaluated based on their greenhouse gas emissions. Landfilling and incineration turned out to be the worst final disposal alternatives, whereas composting and material recovery displayed savings in emissions. An integrated system (composting, incineration, and material recycling) was found as the best solution among the evaluated scenarios. This study can be used by policymakers for the formulation of an integrated hospital waste management plan.
Implications: This study deals with environmental aspects of hospital waste management scenarios. It is an increasing area of concern in many developing and resource-constrained countries of the world. The life cycle analysis (LCA) approach is a useful tool for estimation of greenhouse gas emissions from different waste management activities. There is a shortage of information in existing literature regarding LCA of hospital wastes. To the best knowledge of the authors this work is the first attempt at quantifying the environmental footprint of hospital waste in Pakistan. 相似文献
98.
Fatemeh Ghanbary Nasser Modirshahl Morteza Khosravi Mohammad Ali Behnajady 《环境科学学报(英文版)》2012,24(4):750-756
Titanium dioxide (TiO2) nanoparticles were prepared by sol gel route. The preparation parameters were optimized in the removal of 4-nitrophenol (4-NP). All catalysts were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). An artificial neural network model (ANN) was developed to predict the photocatalytic removal of 4-NP in the presence of TiO2 nanoparticles prepared under desired conditions. The comparison between the predicted results by designed ANN model and the experimental data proved that modeling of the removal process of 4-NP using artificial neural network was a precise method to predict the extent of 4-NP removal under different conditions. 相似文献
99.
Ali Zulfiqar Merrium Sabah Habib-ur-Rahman Muhammad Hakeem Sadia Saddique Muhammad Abu Bakar Sher Muhammad Ali 《Environmental science and pollution research international》2022,29(21):30967-30985
Environmental Science and Pollution Research - Several plant species such as grasses are dominant in many habitats including arid and semi-arid areas. These species survive in these regions by... 相似文献
100.