久效磷对黄鳝乙酰胆碱酯酶、羧酸酯酶和磷酸酶活性的影响

采用静态急性毒性实验方法,研究了久效磷对黄鳝脑乙酰胆碱酯酶及肝脏、肾脏羧酸酯酶、碱性磷酸酶、酸性磷酸酶活性的影响.结果表明,在水温(20±2)℃条件下,经0.25 mg·L-1、0.50 mg·L-1、1.00mg·L-1和2.00mg·L-1的久效磷暴露96 h,黄鳝肝脏、肾脏羧酸酯酶和脑乙酰胆碱酯酶活性均显著下降,但两者表现出不同的抑制模式.随着暴露质量浓度的升高,肝脏和肾脏羧酸酯酶活性的下降幅度逐渐变小,而脑乙酰胆碱酯酶活性下降幅度却由小变大.久效磷暴露黄鳝96 h,肝脏、肾脏酸性磷酸酶活性均升高;而肝脏碱性磷酸酶活性升高;肾脏碱性磷酸酶活性降低.久效磷暴露质量浓度与脑乙酰胆碱酯酶和肝脏、肾脏羧酸酯酶活性之间具有剂量-效应关系,酸性磷酸酶和碱性磷酸酶可能在鱼体抵御有机磷农药毒性作用中有着重要的作用,其机理有待进一步研究.此外,本文还探讨了有机磷农药靶标酶乙酰胆碱酯酶和解毒酶羧酸酯酶、磷酸酶之间的相关性.     

工程安全与工程安全人才培养

在当今人类社会,工程安全已成为威胁人类生存和发展的重大问题。工程安全事故因工程的固有属性而具有诱发原因的复杂性、客观表现的长期性和内在因素的关联性。工程安全事故产生的根本原因之一是人员的工程行为违背了工程安全的客观规律。在现代工程系统中,高级工程技术人员的工程行为对工程安全具有至关重要的影响,而高级工程技术人员的工程行为又与其接受的高等工程教育密切相关。从工程安全的角度审视我国现行高等工程教育,无论在人才培养的结构上,还是在人才培养的内容和方法上都存在诸多问题,改革的重点在于要将工程安全素质纳入工程人才的培养目标并建立与之相适应的工程人才培养模式,更新缺乏现代工程科学技术知识的课程体系和教学内容,创新注重工程安全实践训练的方法和培养途径。     

三峡库区地质灾害监测技术及展望

笔者综述了三峡库区地质灾害监测技术的应用现状。在论述当前地质灾害监测技术存在的问题的基础上,提出了新型的基于Internet的地质灾害远程、集中监测系统,并详细讨论了该技术的原理、结构、应用前景以及功能完善和发展方向。新型安全监测系统的使用可有效防止库区地质灾害的发生,控制其潜在危害;提高库区整体预警管理水平,有效增强防灾减灾能力;显著降低库区安全监测系统运行成本。     

Markers of oxidative stress and toxicant exposure among young waterpipe smokers in the USA

Waterpipe (aka hookah) tobacco smokers are exposed to toxicants that can lead to oxidative DNA and RNA damage, a precursor to chronic disease formation. This study assessed toxicant exposure and biomarkers of DNA [8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG)] and RNA [8-oxo-7,8-dihydroguanosine (8-oxoGuo)] oxidative damage during smoking of flavored and non-flavored waterpipe tobacco. Thirty waterpipe smokers completed two counterbalanced 2-h lab waterpipe smoking sessions (flavored vs. non-flavored waterpipe tobacco). Urinary concentrations of 8-oxodG and 8-oxoGuo and expired carbon monoxide (eCO) were measured before and after the smoking sessions. A significant increase in the urinary concentrations of 8-oxodG (from 2.12 ± 0.83 to 2.35 ± 0.91 ng/mg creatinine, p = 0.024) and 8-oxoGuo (from 2.96 ± 0.84 to 3.45 ± 0.76 ng/mg creatinine, p = 0.003) were observed after smoking the non-flavored and flavored waterpipe tobacco, respectively. Our results also showed that the mean ± SD of eCO increased significantly after smoking the flavored (from 1.3 ± 1.1 to 20.3 ± 23.6 ppm, p < 0.001) and non-flavored waterpipe tobacco (from 1.8 ± 1.2 to 24.5 ± 26.1 ppm, p < 0.001). There were no significant differences in the means of 8-oxodG (p = 0.576), 8-oxoGuo (p = 0.108), and eCO (p = 0.170) between the flavored and non-flavored tobacco sessions. Smoking non-flavored and flavored waterpipe tobacco leads to oxidative stress and toxicant exposure. Our findings add to the existing evidence about the adverse effects of waterpipe tobacco smoking (WTS) and the need for strong policies to inform and protect young people from the risks of WTS.

     

Feasibility of nanoscale zerovalent iron-loaded sediment-based biochar (nZVI-SBC) for simultaneous removal of nitrate and phosphate: high selectivity toward dinitrogen and synergistic mechanism

Environmental Science and Pollution Research - In the process of water treatment, excessive nitrogen and phosphorus pollutants are of great concern. Therefore, we prepared nanoscale zerovalent iron...     

Pyridinic N–reduced graphene oxide and ZnO composite synergistically enhance photocatalytic performance

Environmental Science and Pollution Research - This paper reports the synthesis of nitrogen-doped reduced graphene oxide (N-rGO)/zinc oxide (ZnO) composite photocatalysts by one-step hydrothermal...     

Explanation of heavy metal pollution in coal mines of china from the perspective of coal gangue geochemical characteristics

Environmental Science and Pollution Research - In the process of coal gangue surface accumulation and underground filling disposal, the heavy metals contained in coal gangue will inevitably...     

考虑公众选择偏好的应急避难安置双阶段选址-分配模型

为使开放避难场所符合公众自行避难的实际情况,借鉴Huff模型量化公众选择行为,构建双阶段选址-分配模型,第1阶段确定开放避难场所位置,第2阶段将溢出容量的灾民二次分配到有剩余容量的避难场所,并利用改进粒子群算法进行求解。研究结果表明：双阶段选址-分配模型能够实现同一需求点灾民前往不同避难场所的过程,管理者干预政策能够使服务人数大幅度增加,避免资源浪费、灾民流离失所且二次分配情况主要依赖于第1阶段的结果。研究结果可为管理部门规划应急避难场所提供参考。     

奥运场馆多姿多彩

2008年将在北京举办的第29届奥林匹克运动会,北京赛区需要31个比赛场馆。其中新建场馆12个、改扩建场馆11个、8个临时场馆。新建的12个场馆是：国家体育场(“鸟巢”)、国家游泳中心(“水立方”)、国家体育馆(体操、手球、蹦床)、北京射击馆(射击)、五棵松体育馆(兰球)、老山自行车馆(场地自行车)、奥