考虑声散射的街道交通噪声预报模型

提出一种预报典型的两侧密集分布建筑物的城市街道交通噪声ＬＡ１０和ＬＡｅｑ声级的计算机仿真模型。模型依据一种修正的虚声源原理。它不仅考虑发生于建筑方面的镜象反射和表面吸收，而且考虑了由于墙面的粗糙性所引起的发生于有限尺寸建筑表面声散射的影响。与实测比较表明本模型可得出良好的预报结果。通过对散射强度加以变化可估计表面声散射对预报声级的影响。结果表明，即使在一个相当混响的场合，镜象反射声能对扩散反射声能     

Prenatal diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in a family with a previous fatal case of sudden unexpected death in childhood

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a potentially fatal inherited disease with a carrier frequency of approximately 1:100 in most Caucasian populations. The disease is implicated in sudden unexpected death in childhood. A prevalent disease-causing point mutation (A985G) in the MCAD gene has been characterized, thus rendering diagnosis easy in the majority of cases. Since the clinical spectrum of MCAD deficiency ranges from death in the first days of life to an asymptomatic life, there are probably other genetic factors—in addition to MCAD mutations—involved in the expression of the disease. Thus, families who have experienced the death of a child from MCAD deficiency might have an increased risk of a seriously affected subsequent child. In such a family we have therefore performed a prenatal diagnosis on a chorionic villus sample by a highly specific and sensitive polymerase chain reaction (PCR) assay for the G985 mutation. The analysis was positive and resulted in abortion. We verified the diagnosis by direct analysis on blood spots and other tissue material from the aborted fetus and from family members.