Biodegradable Chitosan-g-Poly(methacrylamide) Microspheres for Controlled Release of Hypertensive Drug

Chitosan-g-poly(methacrylamide) (CS-g-PMAAm) was synthesized by redox polymerization. The synthesized graft copolymers were used to prepare microspheres (MS) by water/oil (W/O) emulsion technique and cross-linked with glutaraldehyde (GA). Developed microspheres were encapsulated using enalapril maleate (ENAM) as a model drug (hypertension) and characterized by fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. The physico-chemical properties of the microspheres were studied by calculating drug entrapment efficiency, and drug release kinetics. % of encapsulation efficiency (% EE) increased with increase in drug loading and methacrylamide (MAAm) content. The minimum % EE (65.2 ± 1.6) was observed in case of microsphere containing 40 % MAAm, 5 % ENAM and 10 mL glutaraldehyde. The release profiles indicate that formulation containing highest (10 mL) crosslinking agent microspheres has the slow release.     

Process plant safety information repository and support for safety applications

The consideration of safety of processing plants from design to operation involves many tasks. Different techniques and tools have been developed to assist in carry out those tasks. With the advances in computing technologies, both in hardware and software, there is the opportunity to bring together the vast amount of engineering, hazard and risk data and handle them in an efficient way to manage and improve safety throughout the life time of a plant. This paper proposes keeping such data in a process plant safety information repository which can be easily accessed by different safety-related tools to enhance the efficiency of safety identification and analysis tasks.     

Observations of Dust-Storms in China, Mongolia and Associated Dust Falls in Korea in Spring 2003

A joint monitoring of dust-storms that occurred in East Asia from March until May 2003 has been carried. Our discussions include dust-storm observations in the source areas of China and Mongolia, and measurements with satellites and ground monitors in central Korea. Differences were found in the definition and measurement of dust-storms. Over the source area of Mongolia there were 6 dusty days in March, 18 days in April, and 10 dusty days in May. In Inner Mongolia of northern China there were 4 dust-storms with 14 dusty days observed over the three months. In central Korea, a sink area, there were 4 cases of weak dust-storm and 17 dusty days in the spring of 2003. The highest PM10 value was 607 μgm⁻³ and PM 2.3 was 149 μgm⁻³, respectively. These observations identify the growing need for further universal observation practices and dust-storm reporting in future. Observations indicated that snow covered the central part of the Gobi Desert, near the boundary of China and Mongolia, from December until mid-March. This is in contrast to other years when the Gobi was relatively wet, producing unfavourable conditions for the formation of intense dust-storms. In addition, the very strong winds associated with intense cyclones and anticyclones were not apparent and the systems shifted northward during the spring. As a result, the frequency and intensity of observed dust-storms in 2003 in this region were very low. This confirms that there is variability in the frequency of dust-storm formation due to the current process of desertification and climate change.     

Environmental Conditions of Dust Events in Northern China during 2000–2001

To investigate the large-scale environmental conditions of duststorms occurring in Northern China, a synoptic situation of tendust events in Northern China during 2000–2001 was composed andits dynamic features were identified. The composite synoptic situation showed that the occurrence of the ten dust events was associated with the eastward movement of a strong cold high fromMongolia, and the development of a cyclone in Northeast China, which caused the pressure gradient to intensify considerably in Northern China. The upper level circulation revealed that a 500 hPa trough developed rapidly above Northern China, and diagnosis showed that composite ascending motion was pronouncedabove the Siberian district. The change of vertical motion in themiddle and low troposphere above Mongolia was also related to theoccurrence of the ten dust events. When the descendingcurrent, 12 hr before the occurrence, was completely replacedby the ascending current, the instable atmospheric stratificationof the lower troposphere enabled dry dust to be transported from the surface to high altitudes toward Northern China.     

Air pollution control costs and consumption pattern effects A regional analysis

The purpose of this study was to ascertain, through the use of an input-output model, the impact of air pollution control costs on income groups in the Philadelphia Region. The range of increases in consumption expenditure was found to be fairly narrow, with the middle-income group bearing the largest increase (2.9%) and the highest and lowest groups slightly lower increases (about 2%). This finding lends support to the proposition that all income groups would probably share the costs of control equally, which leads to a slightly regressive effect on income distribution. The sharing of the region's air quality costs by other areas was also analyzed.     

White certificates and domestic offset schemes: possible synergies

Next to energy efficiency, in the context of GHG reductions, additional policy mechanisms to the incumbent EU Emissions Trading scheme (EU ETS) are discussed. Such is the case of Non-ETS Domestic Offset (DO) schemes, which can reduce CO₂-eq.emissions in the non-ETS sectors and trade these as CO₂ credits on the ETS market. Taking into account that the EU’s “Linking Directive” (EC 2004) creates the conditions to use credits generated by emission reduction projects certified by the UN Framework Convention on Climate Change Kyoto Protocol (KP) within the EU ETS market, in this paper we employ the institutional analysis method of interactions in order to provide insight of a combined White Certificates (WhC) and DOs cheme. Special attention is paid to the parameters that seem to hamper harmonization of WhC and DO. Aim of this paper is to discuss whether smart market- based instruments, such as WhC, can be complementary to the effectiveness of mechanisms fostering energy efficiency such as DOs projects and vice versa. In this respect, the potential combined scheme is assessed (ex-ante) with the help of standard criteria that refer to the triptych energy, environment & society. Given the outcome of the study made, it is fair to say that such a DO/WhC combined scheme could be selected if the additionality concern is to minimize short term social costs of reaching a certain goal. However recent information and research conducted so far cannot yet uphold an ambition that a WhC/DO scheme of this kind could also drive technical change, keep consumer costs down and be equitable.     

Identification and field evaluation of the female sex pheromone of Stathmopoda masinissa in Korea

The sex pheromone of Stathmopoda masinissa Meyrick, an important pest of persimmon fruit in East Asia such as Korea, China, and Japan, was investigated. A lure using (E4,Z6)-4,6-hexadecadienyl acetate (E4,Z6-16Ac), which was identified as a sex pheromone compound of Japanese population, did not work at all for Korean population. Therefore, components in the abdominal extract of the moth were identified and their attractiveness was evaluated in the field. Two components, E4,Z6-16Ac and (E4,Z6)-4,6-hexadecadien-1-ol (E4,Z6-16OH) were identified from the extract of female abdominal extract in a ratio of 10–15:90–85 by GC–MS analysis with synthetic standards. E4,Z6-16Ac and E4,Z6-16OH were previously identified as EAG-active components of this moth in Japanese population. However, (E4,Z6)-4,6-hexadecadienal (E4,Z6-16Ald), which is one of the abdominal extract components and EAG-active component in Japanese population, was not detected in our samples. In the persimmon orchard, single component of E4,Z6-16Ac or E4,Z6-16OH was not attractive. However, the 1:1 mixture of the two components significantly increased the captures of male S. masinissa. Interestingly, traps baited with E4,Z6-16Ac captured significantly higher number of Oedematopoda ignipicta (Lepidoptera: Stathmopodidae) than the traps baited with E4,Z6-16OH or blend of the two components. The attractiveness of E4,Z6-16Ac to O. ignipicta is a new finding.