Extending the environmental risk assessment for oseltamivir (Tamiflu®) under pandemic use conditions to the coastal marine compartment

In case of an avian-influenza-derived human flu pandemic, an inordinately high use of medicines over several weeks is predicted, in particular for the recommended influenza antiviral oseltamivir (Tamiflu). While the risk of oseltamivir to sewage works and freshwater bodies has already been assessed, the fact that a large percentage of the human population worldwide lives relatively close to the sea raises concern for its environmental compatibility in coastal marine waters. The potential risk of high oseltamivir use to the marine compartment is assessed in this publication, based on the 2003 European Community Technical Guidance Document (TGD) for risk assessment. Subchronic embryo–larval ecotoxicity tests with three marine invertebrates (Pomatoceros triqueter, Annelida; Mytilus edulis, Mollusca; Paracentrotus lividus, Echinodermata) and chronic growth inhibition tests with two different groups of marine microalgae (Isochrysis galbana, Haptophyta; Skeletonema costatum, Heterokontophyta) were performed with the active substance oseltamivir carboxylic acid to derive a dependable marine predicted no-effect concentration (PNEC). This was compared to a predicted environmental concentration (PEC) for oseltamivir in coastal waters, based on the worst-case freshwater PEC. The PEC/PNEC risk characterisation ratio for the marine compartment is well below 1, which in the terminology of the TGD signifies no immediate concern. Further, while oseltamivir may be persistent (P), it is not bioaccumulative (B) nor highly ecotoxic (T) and therefore not a PBT substance. In conclusion, even a high pandemic use of oseltamivir would not lead to a significant risk for the marine compartment, in confirmation of the risk assessment for sewage works and freshwaters.     

Temporal concentration changes of DEET,TCEP, terbutryn,and nonylphenols in freshwater streams of Hesse,Germany: possible influence of mandatory regulations and voluntary environmental agreements

Background, aim, and scope  

The present study focuses on the temporal concentration changes of four common organic pollutants in small freshwater streams of Hesse, Germany. The substances (tris(2-chloroethyl)phosphate (TCEP), the technical isomer mixture of 4-nonylphenol (NP), 2-(t-butylamino)-4-(ethylamino)-6-(methylthio)-s-triazine (terbutryn), and N,N-diethyl-m-toluamide (DEET)) are subject to differing regulations. Whereas the use of NP and the related nonylphenolethoxylates (NPEOs) are almost completely banned under EU directive 2003/53/EC, the herbicide terbutryn is only restricted for use as a herbicide in the majority of member states of the European Union (EU). In contrast, TCEP and DEET are not regulated by legislation, but have been replaced in some products through consumer pressure. The impact of regulation on the environmental concentrations of these pollutants is discussed.     

Human Dimensions of Forest Disturbance by Insects: An International Synthesis

Ecological disturbances of forests by insects have a complex array of associated human dimensions presenting complications for natural resource decision making and relationships between stakeholders and managers. This article discusses the human context of forest disturbances by insects by reviewing four cases of bark beetle forest disturbance from British Columbia in Canada, Bavarian Forest National Park in Germany, the Kenai Peninsula in Alaska, and the north central region of Colorado. Findings and lessons learned from these studies are outlined along with their implications for managing forest disturbances by insects in general. Conclusions focus on the need to assess the broad array of impacts and risks perceived by local residents and the capacity for local action and involvement in managing forest disturbances. Communication and interaction between resource managers and local stakeholders can facilitate the identification of management priorities and potentially reduce some of the risks associated with forest disturbances by insects.     

Substance-related environmental monitoring

Background  Due to the requirements of the EU Water Framework Directive and other legal regulations (e.g., national laws like the German Federal Soil Protection Act), but also due to the implementation of the new EU chemicals management system REACH, environmental monitoring will gain increasing importance for the surveillance of environmental quality as well as for the assessment of chemicals. Against this background, the Work Group on ‘Environmental Monitoring’ of the Division of ‘Environmental Chemistry and Ecotoxicology’ within the German Chemical Society has compiled a position paper on substance-related environmental monitoring. Scope  Core elements of this position paper are the definitions of important terms like monitoring, exposure monitoring, effect monitoring, and integrated monitoring. Moreover, temporal and spatial aspects (monitoring of spatial distributions, trend monitoring, and retrospective monitoring) and their applications are discussed. The main focus of this position paper is the coverage of aspects which have to be observed for the preparation and implementation of a monitoring program. Essential is the clear specification of the targets of the monitoring which determine the development of the monitoring concept and its realization, e.g., if environmental media (compartments) or organisms are most appropriate as samples for the aim of the study. Of course, also the properties of the target substances are important (e.g., lipophilicity/bioaccumulation as pre-requisite for an exposure monitoring with organisms). Finally, the monitoring phases of sample planning, sampling, storage and transport of samples, selection of analytical methods, quality assurance measures as well as reporting are discussed. Perspectives  An important issue for the future is to link the quantification of chemicals in environmental compartments (exposure and pollution monitoring) more closely to the study of biological effects (effect monitoring) than has been the case up to now. Furthermore, by inclusion of a spatial differentiation, a comprehensive evaluation of the state of an ecosystem can be obtained and the relevance of the results improved. Practical examples of monitoring studies which illustrate various aspects covered in this position paper will be presented in a series of publications by members of the Work Group in the following issues of this journal.

Spatial identification by satellite imagery of the crop–fallow rotation cycle in northern Laos

In the mountainous regions of northern Laos, shifting cultivation, or slash-and-burn agriculture, is widely practiced. However, the crop–fallow rotation cycle is becoming shorter owing to forest conservation policies and population pressure, causing loss of productivity that deleteriously affects farmers’ livelihoods in the region. To investigate regional land use conditions, we have developed a method of identifying the crop–fallow rotation cycle from Landsat Thematic Mapper (TM) and Enhanced Thematic Mapper+ (ETM+) data. We assessed the impact of the identified cycle on plant production measured by Normalized Difference Vegetation Index (NDVI). The study site was an area in Luang Prabang Province. Using eight TM and ETM+ images acquired annually from 1995 to 2003, except for 1998, when cloud-free data were not collected, we classified land use in each year as crop or fallow by the presence of vegetation in the late dry season. Conformity with fallow age determined by field investigation was 69.1%. The cultivation frequency from 1995 to 2002 showed that 77,000 ha (17.3% of the study site) had not been used for cropping during the period, but 41,000 ha (9.2%) had been used every year. Of the study site, 129,000 ha (29.1%) was cultivated one or two times, 83,000 ha (18.7%) was three or four times, and 54,000 ha (12.2%) was five or six times. The NDVI of crops in November did not provide sufficient evidence to prove the assumption that a longer fallow period would result in better crop yields. Instead, the regeneration of fallow vegetation was evidenced by the higher NDVI values after longer fallow. More than 8 years would be needed to reach the same NDVI as forest. From the produced maps indicating fallow age and cultivation frequency, we found that areas with high potential for regeneration decreased as cultivation frequency increased. Areas near rivers were intensively used, and fallow length was accordingly short. Low-potential areas were found in the western basin of the Mekong River. This spatial information can be used to detect areas where biomass productivity is at high risk of deteriorating. Readers should send their comments on this paper to: BhaskarNath@aol.com within 3 months of publication of this issue.     

Feasibility of incorporating waste grass clippings (Lolium perenne L.) in particleboard composites

This study investigated some of the important physical (thickness swelling) and mechanical (modulus of rupture, modulus of elasticity and internal bond) properties of single-layer particleboard panels made from eucalyptus (Eucalyptus camaldulensis Dehn.), waste of grass clippings (Lolium perenne L.) and combinations of the two. The chemical properties (pH, holocelluse and alpha cellulose contents, and water, alcohol-benzene and 1% sodium hydroxide solubilities) of the raw materials were also determined. Panels with a 6:94 ratio of grass-to-eucalyptus particles had the required mechanical properties for interior fitments including furniture and general uses. Boards manufactured with 100% grass clippings exhibited the lowest quality. The overall panel properties improved with a lower percentage of grass clippings added. Based on initial results, it also appears that grass should compose no more than 13% to achieve acceptable panel properties for interior fitments and general uses.     

Model-based prediction of long-term leaching of contaminants from secondary materials in road constructions and noise protection dams

In this study, contaminant leaching from three different secondary materials (demolition waste, municipal solid waste incineration ash, and blast furnace slag) to groundwater is assessed by numerical modeling. Reactive transport simulations for a noise protection dam and a road dam (a typical German autobahn), in which secondary materials are reused as base layers, were performed to predict the breakthrough of a conservative tracer (i.e., a salt) and sorbing contaminants (e.g., PAHs like naphthalene and phenanthrene or heavy metals) at the groundwater table. The dam constructions have a composite architecture with soil covers in inclined layers and distinct contrasts in the unsaturated hydraulic properties of the used materials. Capillary barrier effects result in strong spatial variabilities of flow and transport velocities. Contaminant breakthrough curves at the groundwater table show significant tailing due to slow sorption kinetics and a wide distribution of travel times. While conservative tracer breakthrough depends primarily on subsoil hydraulic properties, equilibrium distribution coefficients and sorption kinetics represent additional controlling factors for contaminant spreading. Hence, the three secondary materials show pronounced differences in the temporal development of leached contaminant concentrations with consequences for breakthrough times and peak concentrations at the groundwater table. Significant concentration reductions due to dispersion occur only if the source concentrations decrease significantly prior to the arrival of the contaminant at the groundwater table. Biodegradation causes significant reduction of breakthrough concentrations only if flow velocities are low.     

层次分析法在精细化工园区生态环境效益评价中的应用

介绍了杭州湾精细化工园区的概况;设计指标重要性专家打分表,依据指标得分构造了层次分析法的判断矩阵;运用层次分析法确定了精细化工园区生态环境效益评价指标体系中准则层和指标层的权重,进而依据指标权重分析r影响园区生态化改造的关键指标.结果表明,工业废水达标排放率、工业用水重复利用率、创新投入能力、染料行业单位产品新鲜水消耗量等指标是影响总目标的关键指标.