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161.
Ping Gong Niladri Basu Anton M. Scheuhammer Edward J. Perkins 《Environmental science and pollution research international》2010,17(1):181-186
Background, aim, and scope
Hexanitrohexaazaisowurtzitane (CL-20) is a relatively new energetic compound sharing some degree of structural similarity with hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a known neurotoxic compound. Previously, we demonstrated using a noninvasive electrophysiological technique that CL-20 was a more potent neurotoxicant than RDX to the earthworm Eisenia fetida. In the present study, we investigated the effect of CL-20 exposure and subsequent recovery on muscarinic acetylcholine receptors (mAChRs) to further define the mechanism of reversible neurotoxicity of CL-20 in E. fetida.Materials and methods
We used a noninvasive electrophysiological technique to evaluate neurotoxicity in CL-20-treated worms, and then measured how such exposures altered levels of whole-body mAChR in the same animals.Results and discussion
A good correlation exists between these two types of endpoints. Effect on mAChR levels was most prominent at day 6 of exposure. After 7 days of recovery, both conduction velocity and mAChR were significantly restored. Our results show that sublethal concentrations of CL-20 significantly reduced mAChR levels in a concentration- and duration-dependent manner, which was accompanied with significant decreases in the conduction velocity of the medial and lateral giant nerve fibers. After 7-day post exposure recovery, worms restored both neurochemical (mAChR) and neurophysiological (conduction velocity) endpoints that were reduced during 6-day exposures to CL-20 concentrations from 0.02 to 0.22 µg/cm2.Conclusions and perspectives
Our findings support the idea that CL-20 induced neurotoxic effects are reversible, and suggest that CL-20 neurotoxicity may be mediated through the cholinergic system. Future studies will investigate other neurotransmission systems such as GABA, glutamate, and monoamine. Ion channels in the nerve membrane should be examined to further define the precise mechanisms underlying CL-20 neurotoxicity. 相似文献162.
Langer P Kocan A Tajtaková M Petrík J Chovancová J Drobná B Jursa S Rádiková Z Koska J Ksinantová L Hucková M Imrich R Wimmerová S Gasperíková D Shishiba Y Trnovec T Seböková E Klimes I 《Chemosphere》2007,67(9):S379-S385
In a certain area of Michalovce district in East Slovakia, heavy industrial pollution by polychlorinated biphenyls (PCBs) developed in 1955-1984 and very high PCB levels in environmental and human samples are still persisting. Recently, a total of 2045 adults from this and the surrounding background pollution area have been examined using questionnaire data, thyroid volume by ultrasound (ThV), urinary iodine and serum levels of 15 PCB congeners, hexachlorobenzene (HCB), 2,2'-2-bis(4-chlorobiphenyl)-1,1-dichloroethylene (DDE), 2,2'-bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT), alpha-, beta- and gamma-hexachlorocyclohexane (HCH), thyrotropin (TSH), free thyroxine (FT4), anti-thyroperoxidase antibodies (TPOab) and fasting glucose. As based on our previous findings of strikingly high level of PCBs in fish from high pollution area (e.g. mean level of 375430 ng/g lipid) and considerably lower, but still relatively high level in background pollution area (e.g. mean PCB level of 5150 ng/g), the information on the frequency of fish meals and approximate annual consumption of fish from local waters was obtained by questionnaires. The association of contaminated fish consumption with very high blood levels of PCBs, DDE and HCB and increased ThV as well as with increased frequency of positive TPOab, high values of FT4 and impaired fasting glucose (IFG) was found. These associations were also confirmed in 16 marital pairs from high pollution area with very high PCB level in both members associated with high fish consumption. It was concluded that, due to persistent heavy pollution of waters, soil and food chain namely by PCBs, but also by pesticides (e.g. DDE and HCB) resulting from their previous extensive use in agriculture, the fish from local waters still remains the most important source of these toxic pollutants which results in considerable adverse health effects. 相似文献
163.
Mamontova EA Tarasova EN Mamontov AA Kuzmin MI McLachlan MS Khomutova MIu 《Chemosphere》2007,67(9):S71-S78
Although atmospheric deposition is generally the dominant pathway of PCBs into agricultural food chains, soil ingestion by livestock can be important in some cases. The relationship between PCB levels in cow's milk and in pasture soil was studied in the Irkutsk region in Siberia where an historical atmospheric source(s) of PCBs has led to widespread contamination of soil. Milk samples were collected in spring and again in autumn from 18 different farms and analyzed for PCBs. Pasture soil samples were also collected and analyzed. The PCB concentrations in both milk and soil ranged over more than an order of magnitude between the farms. A good correlation was obtained between PCB levels in autumn milk and in soil. This together with a range of other evidence suggested that ingestion of pasture soil was the dominant source of the PCB contamination in the milk. The average soil ingestion rate was estimated to be 1700 g/d, which is at the upper end of values reported in the literature. This may be due to the arid summer climate or the animal husbandry practices in Siberia. 相似文献
164.
Vrsic S Ivancic A Pulko B Valdhuber J 《Journal of environmental biology / Academy of Environmental Biology, India》2011,32(3):289-294
Green cover in vineyards on steep slopes may play an important role in the reduction of soil erosion. The main objective of this study was to investigate the effect of a permanent green cover (PGC) on soil erosion, together with any loss of nutrients, and to compare it with periodic soil tillage (PST). PST took place in the spring (May) and summer (August), in each second area between rows, in a vineyard with permanent green cover. In the case of PST experimental treatments, on average, 1892 kg of soil ha-1 yr-1 eroded, together with the nutrients. In the case of PGC treatments, the amountof soil erosion was only 92 kg ha-1 yr-1. The greater portion of erosive events occurred after tillage in summer, which was accompanied by heavy rainfall and slow renewal of grass cover (slower than in spring). PGC treatment provided a better environment for the activities of soil macro-organisms (i.e., earthworms belonging to the family Lumbricidae), and mostof the organisms were close to the soil surface. In PST treatment, the majority of macro-organisms were below the area disturbed by the tillage (between 10 and 20 cm). The results of our investigation indicate that, in order to adjust wine production activities to climatic changes in vineyards with permanent green cover, PST in area between rows is more advisable in spring (end of May) than in summer (first decade of August) owing to an earlier establishment of effective grass cover. 相似文献
165.
Geyer HJ Schramm KW Feicht EA Behechti A Steinberg C Brüggemann R Poiger H Henkelmann B Kettrup A 《Chemosphere》2002,48(6):631-644
The elimination half-lives (t1/2) in Sprague-Dawley rats for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2, 3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD), 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) and 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (OCDD) were estimated in long-term studies by Schlatter, Poiger and others. Furthermore, there are some published half-lives of TCDD in adult humans. The average half-life of TCDD in adult humans is approximately 2840 days, while in Sprague-Dawley rats the average t1/2 of TCDD is 19 days. The t1/2 of TCDD in humans is about 150 times that of rats. This factor was used to calculate the t1/2 values of the other polychlorinated dibenzo-p-dioxins (PCDDs) in humans from the rat data. Furthermore, the terminal t1/2 values of PCDDs in adult humans were calculated from the regression equation: logt1/2H = 1.34 logt1/2R + 1.25 which was recently established for 50 xenobiotics (t1/2H = terminal half-lives in days for humans, t1/2R = terminal half-lives in days for rats). The following terminal half-lives in adult humans were obtained: 12.6 years for 1,2,3,7,8-PeCDD, 26-45 years for 1,2,3,4,7,8-HxCDD, 80-102 years for 1,2,3,4,6,7,8-HpCDD and ca. 112-132 years for OCDD. These half-lives of PCDDs are critically compared with measured t1/2 values of PCDDs and other persistent organic pollutants in rats, monkeys and humans. 相似文献
166.
Anton Nahman Willem de Lange Suzan Oelofse Linda Godfrey 《Waste management (New York, N.Y.)》2012,32(11):2147-2153
Food waste is problematic for a number of reasons, including the loss of a potentially valuable food source or resource for use in other processes (e.g. energy generation or composting), wasted resources and emissions in the food supply chain, and problems associated with the disposal of organic waste to landfill. This paper quantifies the household food waste stream in South Africa, in order to draw attention to the magnitude of the problem. In addition, it estimates the economic (monetary) value of the wasted food, as well as the costs associated with disposing putrescible food waste to landfill, in order to highlight the associated costs to society. Costs associated with the loss of a potentially valuable food source are valued using a weighted average market price of the wasted food. Costs associated with the disposal of food waste to landfill are quantified based on estimates of the financial and external costs associated with landfilling. For household food waste alone, the costs to society associated with these two food-waste related problems are estimated at approximately R21.7 billion (approximately US$2.7 billion) per annum, or 0.82% of South Africa’s annual GDP. These costs are therefore significant, particularly considering that household food waste accounts for less than 4% of total food losses across the food supply chain. 相似文献
167.
The impact of granivores on coastal dune seed reserves may be high, increasing along a landward gradient from the littoral
zone as the structural complexity of the habitat increases. Seasonal removal rates of non-native seeds by nocturnal and diurnal
vertebrates and ants from experimental seed trays in two habitats within the Alexandria Coastal Dunefield, South Africa, were
determined. Overall, seed removal was higher in the dune-field bush-pocket habitat than the landward thicket habitat. Nocturnal
vertebrates were the most important seed removers within bush-pockets. The importance of nocturnal vertebrates decreased in
the thicket and there was a shift in the dominant seed removers to diurnal vertebrates. Seed removal by ants and diurnal vertebrates
did not differ significantly between the bush-pockets and thicket while that of nocturnal vertebrates showed a significant
change. This can be ascribed to the abundance of the omnivorous murid rodentGerbillurus paeba exilis in the bush-pockets which is absent from thicket vegetation. 相似文献
168.
Mariusz Markowski Krzysztof Urbaniec Andrzej Budek Marian Trafczyński Walter Wukovits Anton Friedl Mattias Ljunggren Guido Zacchi 《Journal of Cleaner Production》2010
The paper is concerned with estimation of heat and power consumption in a conceptual plant to produce hydrogen from sucrose-containing or starchy biomass by fermentation. A hydrogen plant connected with a sugar factory is regarded as the basic option; the sugar factory serves as a source of sucrose-containing thick juice for the hydrogen plant, where this feedstock is processed to hydrogen. As another option, a stand-alone hydrogen plant in which starch must initially be converted to fermentable glucose solution is considered. The values of key process parameters are assumed on the basis of preliminary experimental data. For both options of the hydrogen plant, heat consumption is estimated taking heat recovery in a heat exchanger network into account. Power consumption is estimated by calculating power needed for pumping of liquid and gaseous process media. 相似文献
169.
The effects of the diarrhetic shellfish poisoning toxins,okadaic acid and dinophysistoxin-1, on the growth of microalgae 总被引:6,自引:0,他引:6
The diarrhetic shellfish poisoning toxins okadaic acid (OA) and dinophysistoxin-1 (DTX-1) are potent phosphatase inhibitors produced by certain species of marine dinoflagellates. OA can cause hyperphosphorylation of a broad range of animal and higherpalnt proteins, but little is known regarding the effects of the DSP toxins on marine organisms or their biological function. A variety of microalgae, including a clone ofProrocentrum lima known to produce both OA and DTX-1, were incubated with solutions of OA and in one case DTX-1 or a combination of OA and DTX-1. OA inhibited the growth of all non-DSP-producing test species at micromolar concentrations, butP. lima was not affected even at much higher levels. This differential activity of OA suggests that the DSP toxins may play an allelopathic role and raises questions regarding the strategies adopted by DSP-producing dinoflagellates such asP. lima to avoid autotoxicity. The effects of DTX-1 on microalgal growth were found to be equivalentt to those of OA, and the effects of both toxins in combination were simply additive. 相似文献
170.
Perceptions of Species Abundance,Distribution, and Diversity: Lessons from Four Decades of Sampling on a Government-Managed Reserve 总被引:2,自引:0,他引:2
J. Whitfield Gibbons
Author to whom correspondence should be addressed. Vincent J. Burke Jeffrey E. Lovich Raymond D. Semlitsch Tracey D. Tuberville J. Russell Bodie Judith L. Greene Peter H. Niewiarowski Howard H. Whiteman David E. Scott Joseph H. K. Pechmann Christopher R. Harrison Stephen H. Bennett John D. Krenz Mark S. Mills Kurt A. Buhlmann John R. Lee Richard A. Seigel Anton D. Tucker Tony M. Mills Trip Lamb Michael E. Dorcas Justin D. Congdon Michael H. Smith David H. Nelson M. Barbara Dietsch Hugh G. Hanlin Jeannine A. Ott Deno J. Karapatakis 《Environmental management》1997,21(2):259-268
/ We examined data relative to species abundance, distribution, anddiversity patterns of reptiles and amphibians to determine how perceptionschange over time and with level of sampling effort. Location data werecompiled on more than one million individual captures or observations of 98species during a 44-year study period on the US Department of Energy's(DOE) Savannah River Site National Environmental Research Park (SRS-NERP) inSouth Carolina. We suggest that perceptions of herpetofaunal speciesdiversity are strongly dependent on level of effort and that land managementdecisions based on short-term data bases for some faunal groups could resultin serious errors in environmental management. We provide evidence thatacquiring information on biodiversity distribution patterns is compatiblewith multiyear spatially extensive research programs and also provide aperspective of what might be achieved if long-term, coordinated researchefforts were instituted nationwide.To conduct biotic surveys on government-managed lands, we recommend revisionsin the methods used by government agencies to acquire and report biodiversitydata. We suggest that government and industry employees engaged inbiodiversity survey efforts develop proficiency in field identification forone or more major taxonomic groups and be encouraged to measure the status ofpopulations quantitatively with consistent and reliable methodologies. Wealso suggest that widespread academic cooperation in the dissemination ofinformation on regional patterns of biodiversity could result byestablishment of a peer-reviewed, scientifically rigorous journal concernedwith status and trends of the biota of the United States. KEY WORDS: Abundance; Amphibian; Biodiversity; Distribution; Landmanagement; Reptile 相似文献