Follow-up on a 1962 case-control study of trace elements as risk factors for stomach cancer in Iceland

In 1988 a follow-up investigation was made of a case-control study conducted in 1962 in Iceland which tested hypotheses that trace elements in pasture grass, drinking water and cow's milk were associated through diet with cancer of the stomach. Samples were collected in 1962 from 26 farms in the northern county of Skagafjardarsysla and 30 farms in the southern county of Rangarvallasysla. The main objective of the present study was to establish the cancer experience of the 297 residents of the 56 farms since 1962. In the records of the Icelandic Cancer Registry 31 cases of cancer of all types were identified. Six were cancers of the stomach and four of these were from control farms. The revised comparison of trace element analyses for case and control farms yielded no change in earlier results for pasture grass in Skagafjardarsysla (excess levels of B, Na, AI, Fe and Cu on cancer farms), but B appeared as a significant deficiency on cancer farms in Rangarvallasysla. Drinking water results were unchanged (no significant differences), but for milk the significantly high mean values of Fe and Zn reported earlier for Rangarvallasysla did not appear. The pronounced geographical variation in Icelandic stomach cancer incidence that was widely cited from 1961–65 is now believed to have been spurious.     

THE BUREAU OF RECLAMATION'S ROLE IN AMERICA'S GROWTH1

ABSTRACT. The Bureau of Reclamation was created to implement the Reclamation Act of 1902 and subsequent legislation to conserve and develop the water resources of the western states for maximum efficient use. This has been accomplished by the planning and construction of major multiple use projects which now supply water to approximately eight million acres of land which annually produce 52 million tons of food and fiber with a gross crop value of approximately $2 billion. Fifteen million people are served with municipal and industrial water supplies and hydroelectric power from Bureau projects now returns $160 million annually to the Treasury. Flood control, recreation, and fish and wildlife enhancement are other major benefits. The Bureau of Reclamation is now undertaking a Westwide Survey of water resources and of the needs of the future which is more far-reaching than anything heretofore accomplished. The information accumulated during this ten-year survey will determine whether there is a necessity for consideration of major interbasin transfer of water supply.     

Evidence for multiple recruitment-cohorts of Puget Sound Dungeness crab,Cancer magister

While sampling intertidally in Puget Sound, Washington, USA, for juvenile Dungeness crab (Cancer magister) in 1984, we found evidence of two distinct cohorts of the same year-class based on sizes of first-instar juveniles (J1) and the spatial/temporal patterns of settlement. In 1988, three distinct cohorts were observed to settle in Puget Sound and its approaches. Settlement of one cohort occurred during May in the Strait of Juan de Fuca and in those areas of Puget Sound closest to the Strait. J1 individuals of this cohort were large (x=7.4 mm carapace width, CW) and comparable in both size and timing of settlement to populations along the Washington coast (e.g. Grays Harbor and Willapa Bay). Initial settlement density of the May cohort was as high as 215 crabs/m² in intertidal eelgrass beds along the Strait of Juan de Fuca and decreased to <2 crabs/m² within Puget Sound and the Strait of Georgia. A second cohort apparently originated in Hood Canal (a deep inland fjord), its size upon settlement in June was significantly smaller (J1 x= 5.3 mm CW) than the May cohort, and it was limited to Hood Canal and areas of Puget Sound close to the mouth of Hood Canal. A third cohort, which settled in late July and August, was the smallest of the three cohorts (J1 x= 4.8 mm CW), and was widely distributed around Puget Sound from Seattle in the south to the USA/Canadian border in the north. We hypothesize that most juvenile recruitment in Hood Canal and Puget Sound originates from parental stocks endemic to their respective basins (Hood Canal and Puget Sound cohorts), but that, on occasion, oceanographic conditions allow substantial influx of Pacific Ocean Dungeness crab larvae (oceanic cohort) through the Strait of Juan de Fuca into Puget Sound. Tracking of spatial/temporal settlement patterns and comparison of J1 sizes proved useful for estimating the probable sources and dispersion of Dungeness crab larvae. Differences in size and time of settlement between various larval cohorts of C. magister may prove useful as biomarkers for tracing circulation patterns within and between inland waters of Washington and the Pacific Ocean. Causes of smaller size and later settlement of the Puget Sound cohort relative to oceanic conspecifics of the same year-class are discussed.Contribution No. 856, School of Fisheries, University of Washington, Seattle     

An Experiment Testing whether Condition and Survival are Limited by Food Supply in a Reintroduced Hihi Population

Abstract: The Hihi (Stitchbird, Notiomystis cincta ) is an endemic New Zealand honeyeater that after European colonization survived on only one offshore island. Attempts to reintroduce Hihi to other islands have been unsuccessful, with populations slowly declining. The main hypothesis for these declines was an inadequate year-round supply of carbohydrate food (nectar and fruit) due to human impacts on the forest habitat. When Hihi were reintroduced to Mokoia, another island with regenerating forest, we tested whether survival was limited by carbohydrate food in the year after release. We conducted an "on-off" experiment in which ad libitum sugar water was available to birds for 2 out of every 4 weeks. We compared the masses of individual birds at the end of on and off periods to identify times when birds lost condition with no supplementary food and would be likely to starve. We also used mark-recapture analysis of resighting data to test whether mortality rates were higher when supplementary food was unavailable. The only effect of the supplementary food was that Hihi spent less time foraging for nectar and fruit and more time foraging for invertebrates. There was no time of year when birds lost mass when the food was taken away, and survival rates were not significantly lower when supplementary food was absent. The low (38%) annual survival rate could not be accounted for by shortage of carbohydrate food, and population viability analysis suggests that the population is likely to slowly decline. Our experiment shows that declines of reintroduced Hihi populations may be unrelated to food supply and that alternative hypotheses should be developed and tested. Our results also show the importance of using experimental methods, when possible, to test hypotheses about factors thought to be limiting reintroduced populations.     

Workshop report on the extraction of foetal DNA from maternal plasma

Objective Cell free foetal DNA (cff DNA) extracted from maternal plasma is now recognized as a potential source for prenatal diagnosis but the methodology is currently not well standardized. To evaluate different manual and automated DNA extraction methods with a view to developing standards, an International Workshop was performed. Methods Three plasma pools from RhD-negative pregnant women, a DNA standard, real-time-PCR protocol, primers and probes for RHD were sent to 12 laboratories and also to one company (Qiagen, Hilden, Germany). In pre-tests, pool 3 showed a low cff DNA concentration, pool 1 showed a higher concentration and pool 2 an intermediate concentration. Results The QIAamp DSP Virus Kit, the High Pure PCR Template Preparation Kit, an in-house protocol using the QIAamp DNA Blood Mini Kit, the CST genomic DNA purification kit, the Magna Pure LC, the MDx, the M48, the EZ1 and an in-house protocol using magnetic beads for manual and automated extraction were the methods that were able to reliably detect foetal RHD. The best results were obtained with the QIAamp DSP Virus Kit. The QIAamp DNA Blood Mini Kit showed very comparable results in laboratories that followed the manufacturer's protocol and started with ≥ 500 µL plasma. One participant using the QIAamp DNA Blood Midi Kit failed to detect reliably RHD in pool 3. Conclusions This workshop initiated a standardization process for extraction of cff DNA in maternal plasma. The highest yield was obtained by the QIAamp DSP Virus Kit, a result that will be evaluated in more detail in future studies. Copyright © 2007 John Wiley & Sons, Ltd.     

Spatio-temporal variability in the distribution of epi- and meso-pelagic acoustic backscatter in the Irminger Sea,North Atlantic,with implications for predation on<Emphasis Type="Italic"> Calanus finmarchicus</Emphasis>

The deep scattering layers of the North Atlantic, including the Irminger Sea, contain many predators of the key copepod species Calanus finmarchicus. Previous seasonally restricted studies have described the deep acoustic scattering layers of the Irminger Sea as ubiquitous. They have shown that the intensity of the acoustic backscatter varies across the region, and so, by implication, the potential predation pressure on C. finmarchicus also varies spatially. This paper reports observations of the distribution of epi-pelagic (0–200 m) and meso-pelagic (200–1,000 m) acoustic backscatter in the Irminger Sea, made using a scientific echosounder operating at 38 kHz during four seasonal (winter, spring and summer) cruises. Our study demonstrates that the intensity of the backscatter varies seasonally in regionally distinct ways across the Irminger Sea. The mean acoustic backscatter, both in the upper 800 m and upper 200 m of the water column, varied significantly between the northern, central and southern areas of the central basin (open ocean), and within each area between the Greenland shelf slope, open ocean and Mid-Atlantic Ridge subregions. Different patterns of seasonal change in the acoustic backscatter between the upper 800 m and upper 200 m were also seen, indicating both persistent differences in the underlying amount of backscatter in each area, and varying patterns of seasonal increase in the near surface backscatter in the different areas and subregions. These observations could be related to the different oceanographic regimes encountered in each location, and are discussed in terms of their implications for potential predation pressure on C. finmarchicus.Communicated by J.P. Thorpe, Port Erin     

Evaluating a small deposit next to an economically viable gold mine in West Africa from the points of view of the mining company,the government and the local community

This paper addresses the question of evaluating how much the different stakeholders stand to gain from a mining project. By carefully analysing the breakdown of the cash-flows generated, we were able to estimate the amounts received by the local community and by the national community (outside the mining area), the taxes and royalties received by the government and the profits made by the mining company. A real options framework was used to take account of the inherent uncertainty on the commodity price and the reserves, and the operating flexibility (that is, the possibility for the company to stop mining if the commodity price drops and/or the reserves prove to be lower than that had been envisaged). A synthetic case-study of a gold mine in West Africa was used to illustrate how this procedure could be applied in practice. By using the real option framework we were able to envisage scenarios for developing an extension to a deposit as a function of future values of the commodity price. The procedure proposed should provide governments and NGOs with more objective data for making policy decisions.     

Participatory development for regional sustainability in Western Australia: an enabling state?

Regionally specific sustainability processes that account for diverse environments and populations and that integrate social, economic, political and ecological spheres are being developed in Western Australia. A coordinated commitment to sustainability principles and a participatory philosophy by the state and local governments is necessary. This requires a transformation of the public service, from a director of passive programmes and laws to a facilitator of community projects and outcomes, towards an enabling state. An international participatory paradigm provides an array of concepts and methods for local and regional communities in partnership with government and industry to achieve this. Participatory methodologies are utilised successfully around the globe to create an institutional framework that facilitates a process of dialogue, partnership, networking, learning and managing change. This paper examines the potential contribution of a participatory approach to improve the participatory capacity of regional communities and both local and state governments towards the facilitation of regional sustainability processes.     

The on-road experiences and awareness of sleepiness in a sample of Australian highway drivers: A roadside driver sleepiness study

Objective: Driver sleepiness contributes substantially to road crash incidents. Simulator and on-road studies clearly reveal an impairing effect from sleepiness on driving ability. However, the degree to which drivers appreciate the dangerousness of driving while sleepy is somewhat unclear. This study sought to determine drivers' on-road experiences of sleepiness, their prior sleep habits, and personal awareness of the signs of sleepiness.

Methods: Participants were a random selection of 92 drivers traveling on a major highway in the state of Queensland, Australia, who were stopped by police as part of routine drink driving operations. Participants completed a brief questionnaire that included demographic information, sleepy driving experiences (signs of sleepiness and on-road experiences of sleepiness), and prior sleep habits. A modified version of the Karolinska Sleepiness Scale (KSS) was used to assess subjective sleepiness in the 15 min prior to being stopped by police.

Results: Participants' ratings of subjective sleepiness were quite low, with 90% reporting being alert to extremely alert on the KSS. Participants were reasonably aware of the signs of sleepiness, with many signs of sleepiness associated with on-road experiences of sleepiness. Additionally, the number of hours spent driving was positively correlated with the drivers' level of sleep debt.

Conclusions: The results suggest that participants had moderate experiences of driving while sleepy and many were aware of the signs of sleepiness. The relationship between driving long distances and increased sleep debt is a concern for road safety. Increased education regarding the dangers of sleepy driving seems warranted.