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21.
Pfeiffer syndrome is an autosomal dominant disorder characterized by coronal craniosynostosis, midface hypoplasia, broad thumbs and great toes. On the basis of clinical findings, three subtypes have been delineated. The clinical variability of Pfeiffer syndrome as well as other causes of craniosynostosis can make a prenatal diagnosis based on sonography alone difficult. We describe a fetus in whom sonographic findings (including 3D ultrasound) suggested a Pfeiffer syndrome type II and in which subsequent molecular analysis verified the diagnosis by identifying a de novo mutation in the FGFR2 gene. To the best of our knowledge, this is the first report of a prenatal molecular diagnosis of Pfeiffer syndrome in a patient without family history. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
22.
Bernd Hanisch Bettina Abbas Werner Kratz Gerrit Schüürmann 《Environmental Sciences Europe》2004,16(4):223-238
Goal
In the Brandenburg State Office for the Environment an approach to assess the potential risk of drug residues in aquatic ecosystems has been developed based on an investigation of the consumption amounts in 1999 to identify or to exclude a potential environmental risk of important human drugs and further to define priority substances for monitoring programs in Brandenburg in the future.Method
This assessment approach tested with 60 drug agents is based on an exposure estimation considering the main path for the entry human—waste water—sewage plant—surface water, on a substance specific analysis of effects and on an analysis of the environmental fate as compartment distribution, bioaccumulation and persistence.Results
In Brandenburg surface waters the drug agent concentration for eight of the considered substances is supposed to be greater than 1 μg/l and for at least 13 of the considered substanoes the PNEC in aquatic ecosystems is assumed to be lower than 1 μg/l. A potential risk for the environment can be seen for the antibiotics Ciprofloxacin-HCl and Clarithromycin, the disinfectants Benzalkonium Chloride, Cocospropylendiaminguaniacetat, Glucoprotamine, Laurylpropylenediamine and Polyvidone-iodine, the sexual hormon Ethinylestradiol, the antidiabetic Metformin-HCl, the antiepileptic Carbamazepine and the lipid regulator Clofibrinic acid on the basis of effects because their PEC:PNEC-relation is about 1 or higher. For further 19 drug agents an environmental risk is to be assumed because of their environmental behaviour without support by ecotoxicological data at present.Conclusion
Although there is only a small base of valid ecotoxicological data, this risk assessment shows that adverse effects in the aquatic environment by some drug agents cannot be excluded. However, it should be noted that this first assessment gives only a crude orientation. Appropriate test data are necessary to refine the assessment in future. 相似文献23.
Bettina Matzdorf 《Environmental Sciences Europe》2004,16(2):125-133
Background and Objectives
As an instrument of agro-environmental economic policy, remuneration to farmers for implementing ecologically sound practices are often identified as beingthe alternative to inefficient or unpopular legal instruments. This paper shows that such an approach assumes to be an idealized conception of the way in which economic instruments work. Only result-oriented payment is capable of matching such an idealized conception; hence, the conditions are accordingly ambitious.Key aspects
Starting from a definition of result-oriented remuneration for ecological benefits, this approach is systematically contrasted by action-oriented payments. Either is examined in respect to its comparative efficiency enabling assessment of the potential of both instruments. In the second section, the limits of the approach using result-oriented payments are discussed in relation to the corresponding prerequisites set down for them.Results
The key criterion for distinguishing between result-oriented payments on the one hand and action-oriented payments and legal instruments on the other is the number of options available to the farmer when he/she chooses to take advantage of the payments. On the basis of this criterion, the following advantages emerge from the economic (rewards-based) approach: it promotes self-interest, increases innovative potential, reduces informational asymmetries, promotes continuity, promotes co-operative practice, promotes intrinsic motivation and, finally, it achieves a distribution of risks between farmers and society. However, one essential requirement for applying such instruments are indicators attached to payment. The attempt to develop such indicators reveal three central problems: the complexity of cause-and-effect relations, the diversity of environmental objectives and the normativity of the process by which indicators are devised. These problems simultaneously define the limits of the instrument of result-oriented payments for ecological benefits.Conclusions
No general statements can be made about whether result-oriented payments are preferable to other instruments, as this depends on the concrete circumstances and, in particular, on the specific environmental issues involved, along with the possibilities of developing environmental indicators. However, from the economic point of view, the benefits of result-oriented payments are obvious, as long as the prerequisites for the application of this instrument can be met.Further Research and Recommendations
Given the persuasive benefits of result-oriented payment from an economic point of view, more efforts should in future be made to test the practicability of such instruments. Two examples of result-oriented payment are discussed in this paper. 相似文献24.
Bettina Mahler Viviana A. Confalonieri Irby J. Lovette Juan C. Reboreda 《Behavioral ecology and sociobiology》2008,62(7):1193-1199
For avian brood parasites in which individual females are host-specialists, the arms race between hosts and parasites has
favored egg color polymorphism in the parasite, with female lineages laying mimetic eggs that resemble those of the host species
they parasitize. Female sex-linked inheritance of egg color fosters evolutionary stability of egg polymorphism if female lineages
show both consistent eggshell color and host use. This co-evolutionary relationship is unlikely to occur if individual brood
parasites use different hosts or if egg color is not maternally inherited. The shiny cowbird (Molothrus bonariensis) is an extreme generalist brood parasite that shows a very high degree of egg polymorphism. We tested whether egg spotting
in this species has female sex-linked inheritance. If genetic factors controlling the expression of egg spotting were present
on the female-specific W chromosome, we expected co-segregation between spotting patterns and mtDNA haplotypes, as both W
and mtDNA are maternally inherited. In contrast to the known maternal inheritance of spotting patterns in great tits, we found
no associations between eggshell spotting and mtDNA haplotypes, which suggests that eggshell spotting is not maternally inherited
in this cowbird species. 相似文献
25.
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27.
Lorenzo Del Savio Bettina Schmietow 《Journal of Agricultural and Environmental Ethics》2013,26(4):787-796
In this paper we argue that there is a duty to inform consumers about the environmental impact of foods, and discuss what this duty entails and to whom it falls. We analyze previous proposals that justify ethical traceability with arguments from sustainability and the respect for the autonomy of consumers, showing that they cannot ground a duty to inform. We argue instead that the duty rests on the right of consumers not to be harmed, insofar as consumers have an interest in the morality of their own agency that is frustrated if they are not informed about the environmental impact of the production and transport of what they consume. Our argument detaches the regulation of labeling from substantive theories of environmental ethics or perfectionist conceptions of citizens’ responsibility, thus defending a case for labeling that is compelling also for those who take the role of the state to be limited to the prevention of harm. 相似文献
28.
Bettina Mahler Yanina Sarquis Adamson Alejandro G. Di Giacomo Viviana A. Confalonieri Juan C. Reboreda 《Behavioral ecology and sociobiology》2009,63(11):1603-1608
The screaming cowbird Molothrus rufoaxillaris has been long known as a host specialist brood parasite. However, in the past years, the utilization of two new hosts has
been documented. We examined the variation in mitochondrial control region sequences from screaming cowbird chicks found in
the nests of two hosts, the bay-winged cowbird (Agelaioides badius), which is its regular host, and the chopi blackbird (Gnorimopsar chopi), which is a new host, in Formosa Province, Argentina. If a group of females switched to this new host, we expected to find
an association between host use and haplotype frequency distribution, indicating the presence of host-specific female lineages,
whereas we expected no such association if the cowbird population incorporated this new host and females use both hosts simultaneously.
Haplotype frequency distributions differed between cowbird chicks from the nests of both hosts. This indicates that nest choice
by females of this brood parasite is not random and that they preferentially parasitize the nests of the same host species. 相似文献
29.
Mating in the mite Varroa destructor, an ectoparasite of the honeybee, takes place within the sealed brood cell of its host and is triggered by a female sex pheromone consisting of three fatty acids and their respective ethyl esters. In a laboratory bioassay, we observed interactions among offspring of a Varroa female at 11 days after host cell capping in the absence and in the presence of the sex pheromone and clearly demonstrated that male mites were not able to distinguish between receptive daughters and either older or immature and unreceptive females when exposed to the pheromone. In addition, mating attempts in the presence of the pheromone with otherwise receptive females were clearly of shorter duration and males often failed to select a receptive female. In order to evaluate the effect of pheromone exposure on successful copulations and the number of spermatozoa transferred under field conditions, we sprayed one of the pheromone components, oleic acid, on an empty brood comb before host egg-laying and Varroa infestation and counted the spermatozoa of daughter mites taken from this comb. We could show that the number of spermatozoa was indeed reduced, and 20 % of females lacked spermatozoa. Our results open up new possibilities and represent a promising step toward biological control of Varroa mites in beehives. 相似文献
30.
Janine W. Y. Wong Bettina Hitzfeld Michael Zimmermann Inge Werner Benoît J. D. Ferrari 《Environmental Sciences Europe》2018,30(1):49