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排序方式: 共有226条查询结果,搜索用时 15 毫秒
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Xiaofei Wang Pei Huang Yun Liu Hua Du Xinan Wang Meimei Wang Yichen Wang Tom K. Hei Lijun Wu An Xu 《环境科学学报(英文版)》2015
Microcystin-LR (MC-LR) is the most abundant and toxic microcystin congener and has been classified as a potential human carcinogen (Group 2B) by the International Agency for Research on Cancer. However, the mechanisms underlying the genotoxic effects of MC-LR during chronic exposure are still poorly understood. In the present study, human–hamster hybrid (AL) cells were exposed to MC-LR for varying lengths of time to investigate the role of nitrogen radicals in MC-LR-induced genotoxicity. The mutagenic potential at the CD59 locus was more than 2-fold higher (p < 0.01) in AL cells exposed to a cytotoxic concentration (1 μmol/L) of MC-LR for 30 days than in untreated control cells, which was consistent with the formation of micronucleus. MC-LR caused a dose-dependent increase in nitric oxide (NO) production in treated cells. Moreover, this was blocked by concurrent treatment with the NO synthase inhibitor NG-methyl-l-arginine (l-NMMA), which suppressed MC-LR-induced mutations as well. The survival of mitochondrial DNA-depleted (ρ0) AL cells was markedly decreased by MC-LR treatment compared to that in AL cells, while the CD59 mutant fraction was unaltered. These results provided clear evidence that the genotoxicity associated with chronic MC-LR exposure in mammalian cells was mediated by NO and might be considered as a basis for the development of therapeutics that prevent carcinogenesis. 相似文献
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Christiane Hassenrück Carin Jantzen Günter Försterra Verena Häussermann Philippe Willenz 《Marine Biology》2013,160(11):2919-2927
It has been hypothesized that endolithic photo-autotrophs inside the skeleton of cold-water corals may have a mutualistic relationship with the coral host positively affecting coral calcification. This study investigated the effect of endolithic photo-autotrophs on the apical septal extension of the cold-water coral Desmophyllum dianthus at Fjord Comau, southern Chile (42.41°–42.15°S, 72.5°W). The fluorescent staining agent calcein was used to document the linear apical extension of septae for a period of one and a half years between 2006 and 2007. The results showed a severe reduction in extension rates associated with the presence of endolithic photo-autotrophs. Infested individuals grew about half as fast as non-infested polyps with a median value of 1.18 μm day?1 compared to 2.76 μm day?1. Contrary to the initial hypothesis, these results point toward a parasitic relationship between D. dianthus and its endolithic photo-autotrophs potentially impairing coral fitness. However, further data on physiological parameters and other aspects of the calcification process are necessary to confirm these findings. 相似文献
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Ursula Stephan Ute Strobel Philip Weller Jasmine Bachmann Renate Klaß 《Environmental Sciences Europe》1999,11(6):313-320
10 years ago, the WWF (World Wide Fund for Nature) began to support the work of environmental protection in the countries of Eastern Europe. A main topic is the Danube-Carpathian Program. With the beginning of the bombardements, connected with great amounts of chemicals released directly and as clouds from the fires and explosions, the question raises: What are the consequences for mankind and nature? Is there a risk for the Danube-Carpathian Program? The WWF feels responsible for reporting about these consequences. In July 1999, a group of two Oil Experts and two scientists (each a chemist and a toxicologist) visited Belgrad, Pan?evo and Novi Sad, took samples of soil and water, and estimated the contents of dangerous substances. The first findings and the first consequences for nature and human health are described. 相似文献
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