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41.
Non-invasive prenatal screening (NIPS) has revolutionized the approach to prenatal fetal aneuploidy screening. Many commercial providers now offer analyses for sub-chromosomal copy number variations (CNVs). Here, we review the use of NIPS in the context of screening for microdeletions and microduplications, issues surrounding the choice of disorders tested for, and the advantages and disadvantages associated with the inclusion of microdeletions to current NIPS. Several studies have claimed benefits; however, we suggest that microdeletions have not demonstrated a low enough false positive rate to be deemed practical or ethically acceptable, especially considering their low positive predictive values. Because a positive NIPS result should be confirmed using diagnostic techniques, and false positive rates are as high as 90% for some microdeletions, diagnostic testing seems preferable when the goal is to maximize the detection of microdeletion or microduplication syndromes. 相似文献
42.
Sverker Evans 《Journal of environmental radioactivity》1985,2(1):41-57
To meet the new regulations of maximum yearly releases from Swedish nuclear power plants issued by the Swedish National Radiation Protection Institute, and to make realistic calculations of collective dose commitment derived from radionuclides discharged to the Baltic Sea, a box model AQUAPATH-BALTIC has been developed. The model calculates radionuclide concentrations in 25 boxes for discharges into given compartments and takes into consideration the dispersion rates of the water masses, the sediment-water interaction and radioactive decay. The calculated concentrations in water and sediment at steady state are then used to evaluate individual and collective intakes of activity and external exposures. The radiation doses to the global population following discharges to the Baltic Sea are also calculated. 相似文献
43.
Roger M. Evans Myra O. Wiebe Sandra C. Lee Shawn C. Bugden 《Behavioral ecology and sociobiology》1995,36(1):17-23
According to Trivers (1974), parent-offspring (P-O) conflict arises because offspring are selected to solicit more care than parents are selected to provide. However, should benefits fail to increase with increasing care, the offspring optimum can be reduced to the point where predicted P-O conflict vanishes. We examined offspring demand and parental care in such a benefit-limited system in herring gulls (Larus argentatus). In this species, parents typically neglect their lasthatched (C-) egg during the final hours of hatching (pipped-egg stage), allowing mean temperature to drop by about 4°C, to near 33°C. Other studies indicate that no increased offspring benefit arises from increasing pipped egg incubation temperature above that level, but embryo damage occurs if temperature drops lower. In such a system, P-O conflict over preferred incubation temperature is predicted to be minimal or absent. We assessed phenotypic manifestations of conflict by determining incubation temperature preferences of parent and offspring independently. Temperature provided solely by parental initiative was 33.9°C (artificial eggs, corrected for embryonic heat production). Preferred incubation temperature of pipped embryos was measured by exposing them to moderate chilling (20°C) punctuated by 4-min periods of rewarming when they called. Temperature of vocally thermoregulating embryos stabilized around a mean of 32.9–33.4°C, about 0.5–1.0°C below parental preference. Acting independently, parents and embryos each maintained egg temperature at or near minimum developmentally safe levels. Results provided no evidence for phenotypic conflict, as predicted by a benefit-limited version of Trivers' P-O conflict model. Benefit limitation may also be relevant to P-O conflict in other contexts such as feeding of newly-hatched young. 相似文献
44.
Risk-based regulation assumes that risk assessment can evaluate risks against policy objectives. However, policy goals are often ambiguous and require risk assessors to interpret them for use in risk assessment. This risk assessment-policy gap stems partly from normative and imprecise policy language but is rooted more fundamentally in society's uncertain expectations for the environment. Until this uncertainty is resolved, the democratic and regulatory effectiveness of risk regulation will be undermined by ad hoc policy decisions abdicated to risk assessors. 相似文献
45.
Ronald F. Chamblee Marshall C. Evans Donna G. Patten June S. Pearce 《Journal of Safety Research》1983,14(1):21-35
This article provides national data on the types of injuries reported on death certificates, the external causes of these injuries, and diseases that are frequently reported with them. Injuries were a factor in 11 % (213,366 deaths) of the deaths to residents of the United States in 1978. Of 11 broad categories of injuries, three (fractures, sprains, strains, and dislocations, intracranial injuries, and adverse effects) were mentioned on almost 50,000 deaths each. There was considerable variation in the distribution of injury types by age, sex, and race. The most notable example was fractures of the lower limb which were mentioned on 29% of the deaths involving an injury to 65 + year olds but no less than 5% of such deaths for all other age groups. For white females, the percentage with a fracture of the lower limb was 23 % compared to 12 % overall. In 25 % of the deaths involving an injury, the immediate cause was a motor vehicle accident. In 51 %, the immediate cause of the injury was a non-motor-vehicle accident. In 73 % of the deaths involving non-motor-vehicle accidents, disease conditions as well as injuries were a factor; and, 69% of the time, the disease condition was actually the underlying cause of the death with the injury being a contributing factor or complication. For example, over 14,000 deaths in 1978 involved a circulatory condition as the underlying cause of death which was complicated by an accidental fracture, sprain, or dislocation. Although diseases more often assumed the role of the underlying cause of death, they were also a nonunderlying cause in 24,000 non-motor-vehicle accident deaths. Over 12,000 of such deaths involved circulatory diseases. 相似文献
46.
The use of coefficients, derived from cross-sectional mortality studies, for air pollution risk assessment is quite controversial. In this study, the major limitations of cross-sectional studies are reviewed. The consistency of results from the major recent cross-sectional studies is examined, and the sensitivity of results to model specification is analyzed. Finally, the implications for risk assessment of our inquiries are discussed. 相似文献
47.
The effects of pathway configuration, landmarks and stress on environmental cognition 总被引:1,自引:0,他引:1
Gary W. Evans Mary Anne Skorpanich Tommy Grling Kendall J. Bryant Brian Bresolin 《Journal of environmental psychology》1984,4(4):323-335
The results of this study indicate that manipulations of the pathway grid configuration and landmark placement in a setting cause changes in environmental knowledge. These experimental manipulations were accomplished using a realistic, dynamic simulation technique at the Berkeley Environmental Simulation Laboratory. Measures of environmental knowledge include: memory for incidental information along the simulated urban route, accuracy of route maps, relocation memory for scenes along the route, and questionnaire measures. Data are also presented showing both positive and negative effects of stress from noise on the processes of environmental cognition. 相似文献
48.
M. E. Evans 《Die Naturwissenschaften》1983,70(10):485-494
Two distinct types of motion are commonly attributed to the geomagnetic poles — polar wander and dipole wobble. But two or three decades of intensive effort have failed to provide a sound understanding of either. Why? Polar wander is a very slow phenomenon associated with time scales of 107 to 108 years and thus intimately connected with the drift of the continents arising from plate tectonics. While there is no question of the validity of relative movements between the continents and the pole, the possibility of independent polar motion remains debatable. Dipole wobble is a more rapid phenomenon, most likely associated with time scales of 106 years or less. Currently the geomagnetic axis diverges from the Earth's spin axis by 11 1/2°, but paleomagnetic data indicate that, when averaged over a million years or so, the two coincide. Dipole wobble is the supposed mechanism responsible. The main difficulty here is one of isolating any dipole effects from perturbations of similar magnitude arising from the non-dipole fraction of the geomagnetic field — the so-called secular variation. Recent studies have significantly advanced our understanding of the secular variation, but the dipole wobble remains enigmatic. 相似文献
49.
50.
Although choristoderes have a good Lower Cretaceous record in Asia, they have never previously been recorded from Jurassic
deposits. Here we describe fragmentary vertebral material referable to Choristodera indet. from the Middle Jurassic Balabansai
Svita of the Fergana Valley, Kyrgyzstan. This provides a significant range extension for the group in Asia and shows that
choristoderes already had a Pan-Laurasian distribution in the Jurassic. 相似文献