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HYPOTHESIS: The open chemical combustions in Zeeburg, Amsterdam, The Netherlands, during the years 1961 up to and including 1969, resulted in a local increased incidence of orofacial clefts during this period. STUDY: A retrospective observational epidemiological study was performed, comparing the trend of the incidence of non-syndromal orofacial clefts during the sixties, for the Zeeburg maternity with that of the Wilhelmina Gasthuis. Both clinics were situated in Amsterdam, but varying in distance and compass direction from the incineration works. Thereafter, the addresses of the mothers giving birth to infants with orofacial clefts were plotted on a map of Amsterdam. RESULTS: Of the 8803 children born in the Zeeburg clinic during this period, 21 had a non-syndromal orofacial cleft, producing an average incidence of 2.4 per 1000 births. For the years 1963 through 1965 the incidence rose dramatically to peak at 7.1 per 1000, before plateauing at an average incidence of 1.68 per 1000 births, still 155% higher than in the Wilhelmina clinic (average incidence of 0.66 per 1000 during the years 1966 through 1969). During the 10 year period the Wilhelmina clinic exhibited no such rise. The incidence of non-syndromal orofacial clefts at the Wilhelmina clinic at no time exceeded 2.3 per 1000 births during the 10 year period. The addresses of the mothers of the Zeeburg clefts were grouped primarily to the northwest (and a smaller group to the west) of the incineration works. CONCLUSION: A relation between the open incineration of the chemicals and a local increased incidence of orofacial clefts seems very likely. 相似文献
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J. W. M. van de Staaij R. Huijsmans W. H. O. Ernst J. Rozema 《Environmental pollution (Barking, Essex : 1987)》1995,90(3)
Highland (altitude 1600 m above sea level) and lowland (altitude −2 m below sea level) populations of the perennial herb Silene vulgaris (Moench) Garcke, were tested on their response to elevated levels of UV-B radiation. Highland populations typically receive high natural UV-B fluxes, whereas lowland populations receive a lower natural UV-B dose. Adaptation to high UV-B levels of the highland population is to be expected. Experimental comparison of growth rates, gas exchange rates, transpiration and biochemical parameters using adult plants as well as seedlings did not show a difference in the response to elevated UV-B levels between the two populations. Individuals of both populations were relatively insensitive to elevated UV-B radiation. The response of alpine and lowland populations of Silene vulgaris is discussed in relation to the dispersal of this species after the last ice age. 相似文献
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Jeffrey H. Gove Ernst Linder Walter M. Tzilkowski 《Environmental and Ecological Statistics》1996,3(1):65-80
The possibility of a bimodal log-likelihood function arises with certain data when the combined removal and signs-of-activities estimator is used. Bimodal log-likelihoods may, in turn, yield disjoint confidence intervals for certain confidence levels. The hypothesis that bimodality is caused by the violation of the equal catchability assumption of the removal model, leading to the combination of contradictory data/models in the combined estimator is set forth. Simulations exploring the effect of the violation of removal model assumptions on estimation and inference showed that the assumption of unequal capture probability influenced the frequency of bimodal likelihoods; similarly, extreme parameter values for probability of capture influenced the number of excessively large confidence intervals produced. A sex-specific combined estimator is developed as a remedial model tailored to the problem. The simulations suggest that both the signs-of-activities estimator and the sex-specific estimator perform equally well over the range of simulations presented, though the signs-of-activities estimator is easier to implement. 相似文献