Environmental Science and Pollution Research - Recently, the burden of lung cancer (LC) has attracted global attention. Meanwhile, LC has become the leading cause of death in China. Many studies... 相似文献
Environmental Science and Pollution Research - To assess the status of hotspots and research trends on geographic information system (GIS)–based landslide susceptibility (LS), we analysed... 相似文献
Polycyclic aromatic hydrocarbon (PAH) exposure and genetic susceptibility were conductive to genotoxic effects including gene damage, which can increase mutational probability. We aimed to explore the dose-effect associations of PAH exposure with damage of exons of epidermal growth factor receptor (EGFR) and breast cancer susceptibility gene 1 (BRCA1), as well as their associations whether modified by Flap endonuclease 1 (FEN1) genotype. Two hundred eighty-eight coke oven male workers were recruited, and we detected the concentration of 1-hydroxypyrene (1-OH-pyr) as PAH exposure biomarker in urine and examined base modification in exons of EGFR and BRCA1 respectively, and genotyped FEN1 rs174538 polymorphism in plasma. We found that the damage indexes of exon 19 and 21 of EGFR (EGFR-19 and EGFR-21) were both significantly associated with increased urinary 1-OH-pyr (both Ptrend < 0.001). The levels of urinary 1-OH-pyr were both significantly associated with increased EGFR-19 and EGFR-21 in both smokers and nonsmokers (both P < 0.001). Additionally, we observed that the urinary 1-OH-pyr concentrations were linearly associated with both EGFR-19 and EGFR-21 only in rs174538 GA+AA genotype carriers (both P < 0.001). Moreover, FEN1rs rs174538 showed modifying effects on the associations of urinary 1-OH-pyr with EGFR-19 and EGFR-21 (both Pinteraction < 0.05). Our findings revealed the linear dose-effect association between exon damage of EGFR and PAH exposure and highlight differences in genetic contributions to exon damage and have the potential to identify at-risk subpopulations who are susceptible to adverse health effects induced by PAH exposure.
To achieve urban sustainability, it is critical to enhance the environment, economy, and society simultaneously. This study adopted the revised genuine progress indicator (GPI) and ecological footprint (EF) to evaluate the ecological efficiency and economic sustainability of the Yangtze River Delta from 2000 to 2018. Spatial analysis was utilized to identify spatial autocorrelation. A total of 27 cities were then partitioned through k-means cluster analysis. The results showed that GPI and ecological efficiency improved rapidly, but economic sustainability showed a downward trend. GPI and GDP had a high degree of spatial correlation, especially in Suzhou-Wuxi-Changzhou Metropolitan Area. However, no spatial correlation existed between GPI and EF. The city with high GEE can reach 3000 $/gha, indicating the city consumed 1 global hectare to create $3000 of genuine economic growth. Shanghai, Hangzhou, and Taizhou were cities with the highest level of economic sustainability and ecological efficiency. The spatiotemporal characteristics of economic sustainability and ecological efficiency revealed in this study will provide theoretical guidance for alleviating ecological pressure and promoting economic sustainable development.