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101.
Rubella is a mild viral disease that typically occurs in childhood. Rubella infection during pregnancy causes congenital rubella syndrome, including the classic triad of cataracts, cardiac abnormalities and sensorineural deafness. Highly effective vaccines have been developed since 1969, and vaccination campaigns have been established in many countries. Although there has been progress, the prevention and diagnosis of rubella remain problematic. This article reviews the implications and management of rubella during pregnancy. © 2014 John Wiley & Sons, Ltd.  相似文献   
102.
Seaweeds exhibit a number of adaptations to cope with strong selective pressures imposed by shallow marine environments. The exceptional ability of the annual, brown seaweed Desmarestia viridis, to produce and store high concentrations of sulfuric acid (H2SO4) in intracellular vacuoles, makes it a particularly compelling model for studies of causes and consequences of acid production in seaweeds. We used two laboratory experiments, as well as measurements of intracellular pH of sporophytes and sea salinity and temperature over an entire growth season at one site in Newfoundland and Labrador (Canada), to test hypotheses about effects of salinity and temperature on acid production and die-off in D. viridis. We show that the acid is continuously and irreversibly accumulated (resulting in an intracellular pH as low as 0.53) as the seaweed grows from recruit to adult (March–June) and that this build-up inevitably culminates into dramatic mass releases of acid and die-offs. Progressive, synchronous death among individuals is under the predominant control of sea temperature (death systematically occurred around 12 °C in both laboratory and field), which suggests the evolution of a life-history strategy in which death occurs at a time when individuals reach a size that may correspond to reproductive maturity. The seaweed exhibits a low tolerance to changes in salinity (death was inevitable below 29 psu), which likely imposes severe limitations on its distribution range throughout its existence as a sporophyte. Our findings suggest that major phenological events and survival in D. viridis are intimately linked to synergistic effects of oceanographic controls, which either impair the ability of the seaweed to retain the acid in its tissues (seasonal sea warming), or contribute to dissipating the acid that is released to the environment (wave and current action). They also provide novel insights into the ecophysiological and evolutionary constraints within which marine organisms adapt.  相似文献   
103.
Drinking water in the vast Arctic Canadian territory of Nunavut is sourced from surface water lakes or rivers and transferred to man-made or natural reservoirs. The raw water is at a minimum treated by chlorination and distributed to customers either by trucks delivering to a water storage tank inside buildings or through a piped distribution system. The objective of this study was to characterize the chemical and microbial drinking water quality from source to tap in three hamlets (Coral Harbour, Pond Inlet and Pangnirtung—each has a population of <2000) on trucked service, and in Iqaluit (population ~6700), which uses a combination of trucked and piped water conveyance. Generally, the source and drinking water was of satisfactory microbial quality, containing Escherichia coli levels of <1 MPN/100 mL with a few exceptions, and selected pathogenic bacteria and parasites were below detection limits using quantitative polymerase chain reaction (qPCR) methods. Tap water in households receiving trucked water contained less than the recommended 0.2 mg/L of free chlorine, while piped drinking water in Iqaluit complied with Health Canada guidelines for residual chlorine (i.e. >0.2 mg/L free chlorine). Some buildings in the four communities contained manganese (Mn), copper (Cu), iron (Fe) and/or lead (Pb) concentrations above Health Canada guideline values for the aesthetic (Mn, Cu and Fe) and health (Pb) objectives. Corrosion of components of the drinking water distribution system (household storage tanks, premise plumbing) could be contributing to Pb, Cu and Fe levels, as the source water in three of the four communities had low alkalinity. The results point to the need for robust disinfection, which may include secondary disinfection or point-of-use disinfection, to prevent microbial risks in drinking water tanks in buildings and ultimately at the tap.  相似文献   
104.
A stochastic ecological model with an integrated equilibrium temperature model was developed to predict microalgae growth and phosphorus removal in cold region waste stabilization ponds (WSPs). The model utilized a Monte Carlo simulation to account for parameter uncertainty. The equilibrium temperature model was parameterized using field data collected from two WSPs in Nunavut, Canada, from 2012 to 2014. The equilibrium temperature model provided good agreement with field data on a daily time step. The full model was run using historic (1956–2005) temperature and solar radiation data from five communities (Baker Lake, Cambridge Bay, Coral Harbour, Hall Beach, Resolute) in Nunavut, Canada. The communities represented a range of geographical locations and environmental conditions. Logistic regression on pooled model outputs showed that mean July temperature and mean treatment season temperature (June 1–September 15, ice-free period) provided the best predictors for microalgae growth. They had a predictive success rate of 93 and 88%, respectively. The modelled threshold (50% probability from the Monte Carlo simulation) for microalgae growth was 8.7 and 5.6 °C for the July temperature and mean treatment season temperature, respectively. The logistic regression was applied to each community (except Sanikiluaq) in Nunavut using historic climate data and a probability of microalgae growth was calculated. Based on the model results, soluble phosphorus concentrations consistent with secondary treatment could be achieved if WSP depth is less than 2 m. The model demonstrated a robust method to predict whether a microalgae bloom will occur under a range of model parameters.  相似文献   
105.
Synthetic-based drilling muds (SBMs) offer excellent technical characteristics while providing improved environmental performance over other drilling muds. The low acute toxicity and high biodegradability of SBMs suggest their discharge at sea would cause minimal impacts on marine ecosystems, however, chronic toxicity testing has demonstrated adverse effects of SBMs on fish health. Sparse environmental monitoring data indicate effects of SBMs on bottom invertebrates. However, no environmental toxicity assessment has been performed on fish attracted to the cutting piles. SBM formulations are mostly composed of synthetic base oils, weighting agents, and drilling additives such as emulsifiers, fluid loss agents, wetting agents, and brine. The present study aimed to evaluate the impact of exposure to individual ingredients of SBMs on fish health. To do so, a suite of biomarkers [ethoxyresorufin-O-deethylase (EROD) activity, biliary metabolites, sorbitol dehydrogenase (SDH) activity, DNA damage, and heat shock protein] have been measured in pink snapper (Pagrus auratus) exposed for 21 days to individual ingredients of SBMs. The primary emulsifier (Emul S50) followed by the fluid loss agent (LSL 50) caused the strongest biochemical responses in fish. The synthetic base oil (Rheosyn) caused the least response in juvenile fish. The results suggest that the impact of Syndrill 80:20 on fish health might be reduced by replacement of the primary emulsifier Emul S50 with an alternative ingredient of less toxicity to aquatic biota. The research provides a basis for improving the environmental performance of SBMs by reducing the environmental risk of their discharge and providing environmental managers with information regarding the potential toxicity of individual ingredients.  相似文献   
106.
We report on our recent efforts towards identifying bacteria in environmental samples by means of Raman spectroscopy. We established a database of Raman spectra from bacteria submitted to various environmental conditions. This dataset was used to verify that Raman typing is possible from measurements performed in non-ideal conditions. Starting from the same dataset, we then varied the phenotype and matrix diversity content included in the reference library used to train the statistical model. The results show that it is possible to obtain models with an extended coverage of spectral variabilities, compared to environment-specific models trained on spectra from a restricted set of conditions. Broad coverage models are desirable for environmental samples since the exact conditions of the bacteria cannot be controlled.  相似文献   
107.
Multi-biomarker approaches are used to assess ecosystem health and identify impacts of environmental stress on organisms. However, exploration of large datasets by environmental managers represents a major challenge for regulatory application of this tool. Several integrative tools were developed to summarize biomarker responses. The aim of the present paper is to update calculation of the “Integrated Biological Response” (IBR) described by Beliaeff and Burgeot (Environ Toxicol Chem 21:1316–1322, 2002) to avoid weaknesses of this integrative tool. In the present paper, a novel index named “Integrated Biological Responses version 2” based on the reference deviation concept is presented. It allows a clear discrimination of sampling sites as for the IBR, but several differences are observed for contaminated sites according to up- and downregulation of biomarker responses. This novel tool could be used to integrate multi-biomarker responses not only in large-scale monitoring but also in upstream/downstream investigations.  相似文献   
108.
The effect of positional isomerism on chemical and photochemical degradations of the Imazamethabenz-methyl (IMBM), a pesticide of the imidazolinone family, has been studied. IMBM is proposed in the form of a mixture of the two positional isomers: meta and para. The development of an effective HPLC method (resolution factor R=1.3) allows us to follow either the abiotic disappearance of the meta and para IMBM and the formation of their breakdown products. The abiotic degradation studies include the chemical hydrolysis, as well as the direct and the indirect photodecomposition. We used TiO(2), a well-known initiator of hydroxyl radicals, to highlight the role of *OH in the indirect photodegradation. This work confirms the different behaviours of positional isomers in the environment. Indeed the chemical or direct photochemical degradation is faster for the meta isomer than for the para. Whereas, concerning IMBM, there is not any prevalent influence of this type of isomerism on the indirect photochemical degradation. The degradation products were tentatively identified by LC-MS, NMR and IR and a degradation pathway was proposed.  相似文献   
109.
A rugged and specific method based on tandem solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of anti-infectives in raw sewage and wastewater plant effluents was developed. Analyte recoveries from spiked effluents ranged from 68 to 104%. Two specific selected reaction monitoring transitions and their peak area ratios were used to avoid false positives and confirm the presence of the targeted substances. Detection limits allowed low nanogram per litre detection (0.3-22 ng L(-1)). The method was successfully applied to real samples from the Montréal wastewater treatment plant. All the studied anti-infectives were found in the wastewater samples in concentrations ranging from 39 to 276 ng L(-1). Mean flows of anti-infectives were estimated from effluent concentrations and it was found that large amounts (>118 g day(-1) up to 830 g day(-1)) are discharged in the receiving waters of the St Lawrence River.  相似文献   
110.
Nitrified leachate recirculation has been proposed as a promising strategy for sustainable landfill management. In four test reactors, nitrate or nitrite was added (250 mg N-NO(x)(-)L(-1)) during municipal solid waste biodegradation. Nitrogen-oxides reduction reactions were monitored. Denitrification was the main nitrogen reducing reaction observed. On one hand, during the acidogenic waste degradation phase, as high amounts of volatile fatty acids (VFA) were present, nitrogen-oxides reductions were interpreted as heterotrophic denitrifications. On the other hand, denitrification reactions occurring during the late methanogenic phase were accompanied by sulphate productions and, as VFA were not detected, it was probably an autotrophic reaction. Denitrification inhibition was observed once. Ammonium concentration increased suggesting the occurrence of a dissimilatory nitrate reduction to ammonium (DNRA). Statistical treatment of analytical data revealed that only H(2)S concentration had a significant negative effect on N(2) production in our system. NO production was observed once when nitrite was injected during the acidogenic phase resulting in a total waste degradation inhibition. These results indicate that the consequences of nitrified leachate recirculation in full-scale landfills need to be carefully examined especially during the acidogenic phase or in the presence of waste containing high quantities of sulphur.  相似文献   
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