Thermal manikin measurements--exact or not?

According to the European prestandard ENV 342:1998, the thermal insulation of cold-protective clothing is measured with a thermal manikin. Systematic studies on the reproducibility of the values, measured with different types of clothing on the commonly used standing and walking manikins, have not been reported in the literature. Over 300 measurements were done in 8 different European laboratories. The reproducibility of the thermal insulation test results was good. The coefficient of variation was lower than 8%. The measured clothing should fit the manikin precisely, because poorly fitting clothing gave an error in the results. The correlation between parallel and serial insulation values was excellent and parallel values were about 20% lower than serial ones. The influence of ambient conditions was critical only in the case of air velocity. The reproducibility of thermal insulation test results in a single laboratory was good, and the variation was lower than 3%.     

Alcohol policy and fatal alcohol-related crashes in Finland 2000–2016

Objective: The purpose of this study was to explore the relationship between annual alcohol consumption per capita/alcohol price index and the number of alcohol-related fatal motor vehicle accidents (AFMVAs). We were particularly interested in whether a tax reduction in 2004 increased the number of alcohol-related accidents.

Method: The data consisted of all fatal motor vehicle accidents (FMVAs) during the years 2000–2016 obtained from a database maintained by the Finnish Crash Data Institute (OTI). The data included all fatally injured drivers. We compared the OTI data to official statistics on annual alcohol consumption and the alcohol price index.

Results: There were 3,447 fatally injured drivers, of which 25% (n = 869) were intoxicated (blood alcohol concentration [BAC] ≥ 0.05%). After the reduction of the alcohol tax in 2004, the alcohol consumption rose 12.4% from 2003 to 2005 and AFMVAs rose 38%. There was a strong correlation (r = 0.7000, P < .018) between the recorded consumption of alcohol and the number of AFMVAs. There was a strong negative correlation between AFMVAs and the combined (retail + restaurant sales) alcohol price index (r = ?0.7863, P = .0005). A linear mixed-effects model showed that a 1-L increase in total alcohol consumption per capita per year increases AFMVAs by 10.6 and a one-unit increase in the price index decreases AFMVAs by 1.8 per year.

Conclusions: The correlation between alcohol consumption and alcohol-related crashes should be considered when making political decisions regarding alcohol price and availability. Any further liberalization of the alcohol policy would likely lead to an increase in alcohol-related fatal motor vehicle accidents. Similar consequences are likely to occur with drugs. Alcohol price policy is an effective way to improve road safety, but other measures taken to prevent FMVAs also seem to reduce the prevalence of AFMVAs.     

Forecasting Air Quality Parameters Using Hybrid Neural Network Modelling

Urban air pollution has emerged as an acute problem in recent years because of its detrimental effects on health and living conditions. The research presented here aims at attaining a better understanding of phenomena associated with atmospheric pollution, and in particular with aerosol particles. The specific goal was to develop a form of air quality modelling which can forecast urban air quality for the next day using airborne pollutant, meteorological and timing variables.Hourly airborne pollutant and meteorological averages collected during the years 1995–1997 were analysed in order to identify air quality episodes having typical and the most probable combinations of air pollutant and meteorological variables. This modelling was done using the Self-Organising Map (SOM) algorithm, Sammon's mapping and fuzzy distance metrics. The clusters of data that were found were characterised by statistics. Several overlapping Multi-Layer Perceptron (MLP) models were then applied to the clustered data, each of which represented one pollution episode. The actual levels for individual pollutants could then be calculated using a combination of the MLP models which were appropriate in that situation.The analysis phase of the modelling gave clear and intuitive results regarding air quality in the area where the data had been collected. The resulting forecast showed that the modelling of gaseous pollutants is more reliable than that of the particles.     

POPs and organic polysufides in sediments of Lake Ladoga

The study included one station close to a pollution source (depth 59 m) and another far from polluted areas (depth 40 m). Samples were analysed for organic chlorine, bromine and sulfur compounds. Samples taken with a corer were sliced to the layers of 0-1, 1-4, 4-7 cm etc. down to the depth of 34 cm. The dating was made with two independent methods, the 210Po method and with the soot particle counting method. The analyses were made with a multiresidue method. Gas chromatography was connected to low resolution mass spectrometry (LRMS) or to high resolution mass spectrometry (HRMS). A different extraction was applied to screen the possible occurrence of polysulfides. Typical chlorophenol and chlorohydrocarbon traces from chlorobleaching of pulp were non-detectable. Also PCDDs, PCDFs, PCBs and various organochloride pesticides, fire retardant residues PBDEs, PBDDs and PBDFs and polychlorinated phenyl salicylates were not detected. Instead, methylated dibenzothiophenes Me-DBTs and Di-Me-DBTs, typical traces of oil based defoamers used in e.g. paper mills were found in the surface layers of the polluted site. Polysulfides were analyzed from layers representing years 1955-1970 from the polluted site. The structures of five congeners were according to GC/MS dimethyl trisulfide, 1,2,3,4-tetrathiepane, pentathiane, 1,2,3,4-tetrathiane and 1,2,4,5-tetrathiepane. Many of the analyzed pollutants have not been reported earlier from Lake Ladoga. The only positive observations were from oil-based defoamers used in paper mills, and from polysulfides, which are either of natural origin or indicate a discharge in the 1950s and 1960s. Owing to the large spreadout and dilution, the concentrations are low even at moderate distances from the pollution centers.     

Prenatal diagnosis of the infantile type of neuronal ceroid lipofuscinosis by electron microscopic investigation of human chorionic villi

Chorionic villus biopsy specimens were studied electron microscopically in six pregnancies at risk of the infantile type of neuronal ceroid lipofuscinosis (INCL). The biopsy was performed in all cases in the first trimester of pregnancy (8–10 gestation weeks) by the transcervical route. In one case, the biopsy was repeated at 17 weeks by the transabdominal procedure. In two pregnancies, the endothelial cells and, to a lesser extent, the mesenchymal cells of the chorionic villi contained unit membrane-bound inclusions typical of INCL. In both cases, the pregnancy was terminated and in one of them identical inclusions were found in the brains and kidneys of the fetus at 20 weeks of gestational age. The children from the remaining four pregnancies are healthy and have shown no signs of the disease.     

Early prenatal detection of diastrophic dysplasia

Diastrophic dysplasia, an autosomal recessive disorder, results in severe short-limbed dwarfism, progressive spinal and joint problems, and secondary psychosocial disability. The results of treatments are unsatisfactory. Four pregnant mothers at risk for an affected fetus were studied with an ultrasound scanner at 16 and 19 weeks of gestation. Each mother had a previous child with diastrophic dysplasia. The biparietal distance and the length of the long bones of the extremities were normal in three fetuses, whereas in one fetus there was a 30 per cent shortening of all long bones. The biparietal distance corresponded with the gestational age in all fetuses. In one fetus, diastrophic dysplasia was confirmed by fetoscopy and fetal radiograph at 19 weeks of gestation after the parents had decided to terminate the pregnancy. The skeletal radiograph and autopsy findings of the fetus verified the diagnosis. All other mothers were followed with repeated ultrasound examinations, and they delivered healthy babies. The retrospective follow-up of the four previous pregnancies and of the present one with affected fetuses disclosed that two mothers had had vaginal bleeding, two lymphedema, one abdominal pains, and one mother had had polyhydramnios. These complications were, however, mild and transient, and they could not be regarded as specific for pregnancies with affected fetuses.     

Formation of aromatic chlorinated compounds catalyzed by copper and iron

This study shows the catalyzing effects of iron and copper on the formation of chlorinated compounds such as chlorobenzenes (ClBzs), chlorophenols (CIPhs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). Both total concentrations and congener distributions have been studied. The parameters and conditions varied during the combustion tests were the complete and incomplete combustion and the metal and chlorine addition. The incomplete combustion promoted the formation of organic chlorinated compounds in flue gas particles. Highly chlorinated congeners of PCDD/F were dominant in the flue gas particles, whereas the importance of lower chlorinated congener were increased in the gas phase. In the complete combustion conditions the concentrations of PCDD/Fs increased when the degree of chlorination were high, nevertheless the concentrations of tetra and penta PCDD/Fs were higher in the gas phase than the concentrations in the fly ash particles. Organic chlorine promoted the formation of chlorinated compounds more effectively than inorganic chlorine, which instead promoted the formation of PCDD/Fs in the gas phase, especially with copper catalyst. Different concentration levels of chlorinated compounds were observed in the gas phase and in particles when the chlorine source and combustion conditions were varied from incomplete to optimum conditions. Both copper and iron seem to have a catalytic effect on PCDD/F formation.     

Lead poisoning and other human-related factors cause significant mortality in white-tailed eagles

The white-tailed eagle (Haliaeetus albicilla) suffered a severe population decline due to environmental pollutants in the Baltic Sea area ca. 50 years ago but has since been recovering. The main threats for the white-tailed eagle in Finland are now often related to human activities. We examined the human impact on the white-tailed eagle by determining mortality factors of 123 carcasses collected during 2000–2014. Routine necropsy with chemical analyses for lead and mercury were done on all carcasses. We found human-related factors accounting for 60% of the causes of death. The most important of these was lead poisoning (31% of all cases) followed by human-related accidents (e.g. electric power lines and traffic) (24%). The temporal and regional patterns of occurrence of lead poisonings suggested spent lead ammunition as the source. Lead shot was found in the gizzards of some lead-poisoned birds. Scavenging behaviour exposes the white-tailed eagle to lead from spent ammunition.     

Amniotic fluid pregnancy-specific β1-glycoprotein (SP1) in Meckel's syndrome: A new test for prenatal diagnosis?

Amniotic fluid levels of pregnancy-specific β₁-glycoprotein (SP₁) were elevated in four pregnancies with Meckel's syndrome at 16 and 26 weeks, and the levels of hCG were also elevated in three out of four cases. These findings suggest a potential new application of SP₁ measurement for prenatal diagnosis.     

Aquatic photochemistry of paracetamol in the presence of dissolved organic chromophoric material and nitrate

Purpose

This study contains some new findings connected to the photolysis of the drug paracetamol (hereinafter APAP) especially in light of estimating natural conditions, and it will offer information to better evaluate environmental problems connected with this widely used analgesic agent. Only a few studies, so far, have focussed on the photodegradation process of APAP in the natural environment, and the question about the role of the colored/chromophoric dissolved organic matter (CDOM) and nitrate (NO ₃ ^? ) as photoinductors is almost open.

Methods

APAP dissolved in freshwater and pure laboratory water in the presence and absence of CDOM and NO ₃ ^? ions was irradiated using weak-energy photon energies simulating natural conditions.

Results

CDOM and NO ₃ ^? as photoinductors produced only the slow phototransformation of APAP under weak energy radiation, and APAP seemed to be practically resistant to direct photolysis under weak radiant energies available in natural conditions. The estimated reaction efficiencies, in addition to half-lives, speak for that NO ₃ ^? and CDOM do not act as quite independent photoinductors but their effect in conjunction (CDOM?CNO ₃ ^? ?Cwater) is stronger than the separate ones. The principal phototransformation intermediates of APAP were mono-hydroxy derivatives, depending on available photon energies formed via ortho- or meta-hydroxylation, possessing substantial power of resistance to further specific transformation reactions.

Conclusions

The estimated half-life of the phototransformation of APAP in the natural aqueous environment and in the presence of suitable photoinductors will be about 30?days or more.