Role of nitric oxide in the genotoxic response to chronic microcystin-LR exposure in human–hamster hybrid cells

Microcystin-LR(MC-LR) is the most abundant and toxic microcystin congener and has been classified as a potential human carcinogen(Group 2B) by the International Agency for Research on Cancer. However, the mechanisms underlying the genotoxic effects of MC-LR during chronic exposure are still poorly understood. In the present study, human–hamster hybrid(AL) cells were exposed to MC-LR for varying lengths of time to investigate the role of nitrogen radicals in MC-LR-induced genotoxicity. The mutagenic potential at the CD59 locus was more than 2-fold higher(p 0.01) in ALcells exposed to a cytotoxic concentration(1 μmol/L) of MC-LR for 30 days than in untreated control cells, which was consistent with the formation of micronucleus. MC-LR caused a dose-dependent increase in nitric oxide(NO) production in treated cells. Moreover, this was blocked by concurrent treatment with the NO synthase inhibitor NG-methyl-L-arginine(L-NMMA), which suppressed MC-LRinduced mutations as well. The survival of mitochondrial DNA-depleted(ρ0) ALcells was markedly decreased by MC-LR treatment compared to that in ALcells, while the CD59 mutant fraction was unaltered. These results provided clear evidence that the genotoxicity associated with chronic MC-LR exposure in mammalian cells was mediated by NO and might be considered as a basis for the development of therapeutics that prevent carcinogenesis.     

科尔沁沙地生态系统服务价值变化研究

研究土地利用变化引起的区域生态系统服务价值的改变。可定量评价土地利用活动对区域生态环境的影响。基于1995年和2000年的土地利用数据．应用谢高地等人制定的中国陆地生态系统单位面积服务价值表．估算了科尔沁沙地土地利用变化引起的生态系统服务价值的改变。结果表明。从1995—2000年5年间。科尔沁沙地的耕地增加4．87％。林地减少2．25％。草地减少0．03％．水域减少1．32％．湿地增加0．54％，城乡工矿居民用地减少3．21％。未利用地减少8．83％；研究区内土地利用变化的区域差异性很大．表现为大部分旗县仍维持着毁林毁草开荒的不合理土地利用活动。科尔沁沙地生态系统服务价值从1995年的1463．67亿元增加到2000年的1467．36亿元。净增加值为3．69亿元，增幅为0．25％；其增加值并非因耕地面积增大所产生．而是个别旗县的大面积沙荒地得到有效治理所致。     

Individual adaptive performance in organizations: A review

Modern work is frequently characterized by jobs where adaptive performance (AP) is crucial for employees to succeed in light of new or altered task demands. This recognition has fueled growing interest in AP as a dimension of workplace performance. To this point, however, research on AP has evolved from disparate perspectives and methods, resulting in fragmentation and a less than coherent knowledge base. This paper presents a comprehensive review of research studies regarding the nomological network of individual AP. In doing so, we synthesize the current knowledge base surrounding correlates of AP, elucidate current ambiguities, and suggest directions for future research efforts. We conclude that although the extant AP literature has amassed a critical body of studies linking various predictors to successful AP outcomes, much remains unknown, most critically regarding the implications of different methods of assessing AP, the effects of different types of changes in the task environment, the process of AP, and the steps organizations can take to foster AP among their employees. We hope that our synthesis and analysis paves the way for efforts to address these important questions. Copyright © 2014 John Wiley & Sons, Ltd.     

现役民机客舱热舒适评价

采用修正热舒适评价值(Corrected Predicted Mean Vote,CPMV)模型,针对实测的国内及国际航线数据进行了客舱环境的热舒适评价.结果表明,当客舱内压力满足适航标准要求范围、相对湿度明显低于舒适性要求时,低压和低相对湿度均能导致热舒适评价值(Predieted Mean Vote,PMV)的正偏移,偏移量为0.3～0.4,即低气压和低湿会使乘客感觉更温暖,但这2个参数对乘客热舒适的影响有限.短途航班热舒适性不理想,部分航班出现过热或过冷现象.     

有机过氧化物在生产、储运过程中的危险与可操作性分析

有机过氧化物的易燃、受热分解等特殊性质和生产、储运过程要求严格的低温条件与操作程序,使得有机过氧化物潜在的危险性很高。通过基于有机过氧化物危险特性及其在生产、储运过程中物质、能量与信息的分析,依据物-能量-信息的安全要素体系,应用危险与可操作分析方法,研究了有机过氧化物的安全理论,在某种程度上是延伸了HAZOP分析的内容。     

高寒条件下振弦式传感器在线测量尾矿坝浸润线的误差分析及对策

为减少和消除高寒条件下振弦式传感器在线测量浸润线的误差,通过理论分析和现场试验,对造成误差的因素及其影响情况进行了深入研究。结果表明,振弦式传感器产生测量误差的主要来源为设备安装深度的测量误差与尾矿水密度及重力加速度的取值误差,并提出了减少或消除误差的方法和工程技术措施,为高寒地区的浸润线在线精确测量提供了重要指导意义。     

The global partnership for sustainable development

This paper examines whether foreign aid, together with other economic, social and environmental factors, contributes to sustainable development. It starts with an illustrative theoretical growth model where foreign aid promotes sustainable development by protecting the environment. Using factor analysis and newly developed estimation methods for a dynamic panel data model with endogenous regressors, the empirical section of the paper finds evidence that foreign aid has had a significantly positive influence on sustainable development in aid recipient countries. This effect is very likely to go through channels related to growth and resources as well as a technology channel with respect to energy intensity. This research has important implications for a post‐2015 development framework on international collective action with regard to a sustainable future.     

PWM变频驱动电机轴电压与轴电流的测试方法

PWM变频器的广泛应用大大改善了电机调速性能,但是,由于PWM变频器共模电压在电机内部耦合电容作用下,形成轴电压和轴电流,会引起轴承早期失效危及系统安全运行。轴电流问题的研究包括对轴电流的分析、预测和抑制。然而这些过程需要轴电压和轴电流的准确测量进行验证和比对分析。设计合理而有效的测量装置和测量方法是非常重要的一环。在分析轴电流产生机理的基础上,对现有的各种轴电流测量方法和轴承阻抗特性测试方法进行介绍,总结对比这几种方法的优缺点,为轴电流的测试平台的新设计提供参考。     

海洋石油工程清洁生产评估方法研究

从资源能源利用、废弃物产生、废弃物回收利用、污染物处理、环境管理效果和环境响应情况着手,建立了包括6个一级指标、29个二级指标的海洋石油工程清洁生产评估指标体系;研究利用专家调查和层次分析法确定各评估指标的权重值,探索评估指标的赋值方法、标准化方法,提出了海洋石油工程清洁生产综合指数计算方法体系。     

FR-1阻化泡沫防灭火技术研究

针对综放孤岛工作面采空区漏风引起浮煤自燃的问题,以天池矿102综放孤岛工作面的应用为例,采用热重实验和热解动力学分析法进行FR-1阻化泡沫防灭火技术研究。对102工作面的煤样在阻化前后进行热重实验,通过热解动力学分析发现,阻化后进、回风巷煤样失水阶段的活化能分别增加了1.63倍和3.21倍;氧化增重阶段活化能分别增加了1.53倍和1.43倍,燃烧阶段活化能降低。现场应用发现,FR-1阻化泡沫具有良好的渗透性和堆积性,采空区的CO浓度不断下降并最终降到0ppm。研究结果表明,FR-1阻化泡沫能有效提高煤的失水活化能,具有良好的阻燃作用,能有效防止综放孤岛工作面的采空区自燃。