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171.
Persistent organic pollutants have been shown to have immunomodulating effects in humans. However, epidemiological evidence regarding the relationships between organochlorine compound exposure and allergic disorders coming from studies of children has been limited and inconsistent. The current cross-sectional study examined the associations between the concentrations of β-hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), p,p'-dichlorodiphenyldichloroethylene (DDE), and trans-nonachlordane in breast milk and the prevalence of allergic disorders in 124 adult Japanese women. The definition of wheeze and asthma was based on criteria from the European Community Respiratory Health Survey whereas that of eczema and rhinoconjunctivitis was based on criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age, smoking, family history of allergic disorders, and education. The prevalence values of wheeze, asthma, eczema, and rhinoconjunctivitis in the past 12 months were 9.7%, 4.8%, 13.7%, and 29.8%, respectively. The median concentrations of β-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk were 28.3, 7.0, 71.6, and 23.9 ng g(-1) lipid, respectively (range, 4.5-253, 2.1-14.5, 7.5-362, and 1.8-130 ng g(-1) lipid, respectively). When the exposures were treated as continuous variables, no significant associations were found between concentrations of HCB, β-HCH, p,p'-DDE, or trans-nonachlordane and the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis. Our results suggest that concentrations of β-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk are not evidently associated with the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis in young female Japanese adults. 相似文献
172.
Nobuo Matsuura Tomoaki Uchiyama Hiroshi Tada Yosikazu Nakamura Naomi Kondo Masatoshi Morita Masaru Fukushi 《Chemosphere》2001,45(8):1167-1171
Dioxins (PCDD + PCDF) and polychlorinated biphenyl (PCB) are potentially hazardous compounds and have structural similarity to thyroid hormones. Our research group on “Dioxins and PCB in Human Milk” was organized in 1997 and has been active for the past three years. We collected breast milk from 80 mothers living in Tokyo, Saitama, Ishikawa and Osaka Prefecture in Japan at 5, 30, 150, 300 postpartum days and measured PCDDs, PCDFs and PCBs during 1998–1999. We added another 20 prefectures and cities during 1999–2000. Breast milk was obtained from 415 mothers at 30 postpartum days (breast-feeding group). Blood was taken from infants who were breast-fed at the age of 1 year for evaluation of thyroid and immune functions. Blood was also taken from 53 infants who were bottle-fed (bottle-feeding group) as a control. Serum T4, T3, FT4 and TSH levels in the breast-feeding (n=337) and bottle-feeding (n=53) groups were within normal ranges and were not significantly different between the two groups. Although there were a large geographic differences of dioxins and co-PCB content in breast milk, there were no differences in serum T4, T3, FT4, TSH levels and no significant correlation between the mean serum levels of TSH and TEQ in breast milk. There was a significant correlation between serum TSH at 1 year of age and that from blood on dried filter paper TSH at 5 days of age. We concluded that dioxin intake from breast milk in Japanese infants did not impair thyroid function. However, long-term effects remain to be evaluated. 相似文献
173.
A very high level of vanadium was found to be contained in the polychaete worm Pseudopotamilla occelata collected in 1992–1993 from the Sanriku coast on the main island of Japan. The vanadium concentration (mean±SD=5500±1800 g g-1 dry wt) in the worm's branchial crown which is composed of many bipinnate radioles was approximately 100 times higher than that (mean±SD=60±25 g g-1 dry wt) in the trunk body. Electron probe X-ray microanalysis revealed that a large amount of vanadium was present in the outer potion of the epidermis of the bipinnate radiole. Analytical electron microscopy for a cryo-section of the bipinnate radioles indicated that vanadium was localized in electron-dense deposits in the apical portion of epidermal cells. From an examination of the fine structures, the locality of the electron-dense deposits were found to correspond to that of the apical vacuoles in the epidermal cells. It was concluded that most of the vanadium in P. occelata was contained in the vacuoles of the epidermal cells of the bipinnate radioles. 相似文献
174.
175.
The effective use of activated charcoal as an oral adsorbent for primary treatment of acute poisoning was investigated in vitro by evaluating the characteristics of mexiletine, an anti-arrhythmic drug, adsorbed onto activated charcoal in the presence of sodium chloride solutions at various concentrations. The equilibrium amount of mexiletine adsorbed onto activated charcoal was increased by the addition of sodium chloride. In particular, there was a marked increase in the amount adsorbed from a solution of lower mexiletine concentration. The removal rate is another important factor in the evaluation of activated charcoal, and a rapid decrease of mexiletine concentration by the addition of sodium chloride was recognized. The acceleration of mexiletine adsorption onto activated charcoal by the addition of sodium chloride was due to the occurrence of salting-out. It could be concluded that the administration of activated charcoal suspended in saline solution was more effective in the primary treatment of acute poisoning by mexiletine overdose. 相似文献
176.
Yohei Nakamura 《Marine Biology》2010,157(11):2397-2406
An extensive seagrass bed on a fringing coral reef at Amitori Bay (southern Ryukyu Islands) disappeared completely in 2009
after a typhoon. Seagrass bed loss had a significant negative influence on not only seagrass bed residents but also commercially
important coral reef fishes that utilize seagrass beds as nurseries or feeding grounds. With seagrass bed loss, mean species’
richness and densities of overall seagrass bed fishes per transect decreased by more than 75 and 85%, respectively. Most of
the affected fishes were benthivores, piscivores, detritivores, and herbivores. Of 21 dominant species, 13 disappeared completely
and 4 showed severe reductions in densities following seagrass bed loss, whereas the densities of 4 bottom-dwelling gobies
did not change significantly. Thus, this study demonstrated that most seagrass bed fishes lack the ability to adapt to seagrass
habitat loss, suggesting that increasing global seagrass loss will cause serious reductions in seagrass-associated fishes
and fishery resources. 相似文献
177.
Hyoe Takata Jian Zheng Keiko Tagami Tatsuo Aono Kazuhiro Fujita Shin-ichi Yamasaki Noriyoshi Tsuchiya Shigeo Uchida 《Environmental monitoring and assessment》2013,185(5):3645-3658
The sediment–water distribution coefficient, K d, is one of the most important parameters in radionuclide assessment models. In this study, we determined K ds of stable iodine (I) in estuarine and coastal regions. We studied 16 estuarine and coastal regions of Japan and obtained I data on water and sediments. Data on salinity, pH, dissolved organic carbon and dissolved oxygen in water, and organic carbon (OC) in sediments were also obtained as estuarine variables. Determined K ds of I in the Sagami River estuary decreased along the salinity gradient (salinity range, 0.1–33.8), indicating that salinity is one of the important factors controlling the K d values; however, when the K d values were compared among all the estuaries, the difference between minimum and maximum K d values varied by about two orders of magnitude in a narrow salinity range of 30.0–34.4. A significant correlation between K d value and OC content in sediments was observed in all the stations with a salinity of ≥30 except for stations in the Ishikari and Onga River estuaries. The exceptions are probably due to different sources of the sediments, which are explained by the results of relatively low I/OC ratios in sediments in those two estuaries, compared to the other estuaries. Thus, OC in sediments as well as salinity may be responsible for the variation of K ds of I in the estuarine and coastal regions. 相似文献
178.
179.
Miyajima K Itabashi G Koshida T Tamari K Takahashi D Arakawa T Kudo H Saito H Yano K Shiba K Mitsubayashi K 《Environmental monitoring and assessment》2011,182(1-4):233-241
Immunoassay methods are generally used for measuring of allergenic substances. However, they need special facilities, skilled handling, and time-consuming procedure. In this work, a fiber-optic immunoassay system which could measure allergen by fluorescent intensities of immune complexes formed by allergens and fluorescently labeled antibodies was established. Immune complexes absorbed on the optical fiber probe surface, and excitation light was injected into the probe, then evanescent field is created in the proximity of the probe. The fluorophores were excited by the evanescent light, and fluorescence was detected by a photo diode. The target allergen detected by our system was Der f1 derived from Dermatophagoides farinae that is one of the house dust mite and major source of inhaled allergens. The fluorophore used labeling on detecting antibody was cyanine 5. The system enabled to detect and quantitatively determine of Der f1. The measurement range was from 0.24 to 250?ng/ml, and the result competes with ELISA. The measurement time was 16?min/sample. The immunoassay system was applied to measurement of Der f1 from actual dust samples. Calculated values of Der f1 showed good correlations between the fiber-optic fluoroimmunoassay and ELISA. 相似文献
180.